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The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4

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Reviews of Physiology, Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 186))

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Abstract

Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which mediate a wide range of physiological functions and are activated and modulated by a diverse array of stimuli. One of this ion channel’s least discussed functions is in relation to the generation and maintenance of certain pain sensations. However, in the two decades which have elapsed since the identification of this ion channel, considerable data has emerged concerning its function in mediating pain sensations. TRPV4 is a mediator of mechanical hyperalgesia in the various contexts in which a mechanical stimulus, comprising trauma (at the macro-level) or discrete extracellular pressure or stress (at the micro-level), results in pain. TRPV4 is also recognised as constituting an essential component in mediating inflammatory pain. It also plays a role in relation to many forms of neuropathic-type pain, where it functions in mediating mechanical allodynia and hyperalgesia.

Here, we review the role of TRPV4 in mediating pain sensations.

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Conflict of Interest

The authors declare that they have no conflict of interest.

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This study is not funded.

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Authors and Affiliations

  1. Anaesthetics, Pain Medicine and Intensive Care Division, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK

    John P. M. White & Istvan Nagy

  2. Department of Anaesthetics, The Queen Elizabeth Hospital, Birmingham, UK

    Mario Cibelli

  3. Department of Molecular and Cellular Medicine (Professor Emeritus), Lab Ion Channel Research, Leuven, Belgium

    Bernd Nilius

  4. School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, UK

    James Graham McGeown

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  1. John P. M. White
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  2. Mario Cibelli
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  3. Istvan Nagy
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  4. Bernd Nilius
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  5. James Graham McGeown
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Correspondence to James Graham McGeown .

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  1. Department of Biology, University of Copenhagen, Copenhagen, Denmark

    Stine Helene Falsig Pedersen

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White, J.P.M., Cibelli, M., Nagy, I., Nilius, B., McGeown, J.G. (2022). The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4. In: Pedersen, S.H.F. (eds) Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 186. Springer, Cham. https://doi.org/10.1007/112_2022_75

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