1. CD69-oxLDL ligand engagement induces Programmed Cell Death 1 (PD-1) expression in human CD4 + T lymphocytes

   • María Jiménez-Fernández
   • Cristina Rodríguez-Sinovas
   • Francisco Sánchez-Madrid

   Original Article Open access 05 August 2022 Article: 468

   

2. Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse

   • Haojie Li
   • Hong Chen
   • Xuejiang Guo

   Original Article 05 August 2022 Article: 467

   

3. Sample-multiplexing approaches for single-cell sequencing

   • Yulong Zhang
   • Siwen Xu
   • Xinghua Pan

   Review 05 August 2022 Article: 466

   

4. Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels

   • Hamza Mameri
   • Géraldine Buhagiar-Labarchède
   • Mounira Amor-Guéret

   Original Article Open access 04 August 2022 Article: 465

   

5. Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes

   • Antonio Arnaiz-Villena
   • Fabio Suarez-Trujillo
   • José Manuel Martin-Villa

   Review Open access 04 August 2022 Article: 464

   

6. Balancing NAD⁺ deficits with nicotinamide riboside: therapeutic possibilities and limitations

   • Angelique Cercillieux
   • Eleonora Ciarlo
   • Carles Canto

   Review Open access 02 August 2022 Article: 463

   

7. α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation

   • Yasuteru Inoue
   • Masayoshi Tasaki
   • Mitsuharu Ueda

   Original Article 02 August 2022 Article: 462

   

8. USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection

   • Phatcharida Jantaree
   • Supattra Chaithongyot
   • Michael Naumann

   Original Article Open access 01 August 2022 Article: 461

   

9. 5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism

   • Ling Huang
   • Junping Zheng
   • Hongtao Liu

   Original Article 01 August 2022 Article: 460

   

10. Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors

    • Li Liu
    • Dmytro Kryvokhyzha
    • Karl Swärd

    Original Article Open access 01 August 2022 Article: 459

    

11. Adult neurogenesis of the median eminence contributes to structural reconstruction and recovery of body fluid metabolism in hypothalamic self-repair after pituitary stalk lesion

    • Yichao Ou
    • Mingfeng Zhou
    • Songtao Qi

    Original Article 30 July 2022 Article: 458

    

12. Aβ_1-42 peptides blunt the adenosine A_2A receptor-mediated control of the interplay between P₂X₇ and P₂Y₁ receptors mediated calcium responses in astrocytes

    • Liliana Dias
    • Daniela Madeira
    • Paula Agostinho

    Original Article 30 July 2022 Article: 457

    

13. Metabolic reprogramming consequences of sepsis: adaptations and contradictions

    • Jingjing Liu
    • Gaosheng Zhou
    • Dawei Liu

    Review 29 July 2022 Article: 456

    

14. NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation

    • Beatriz Martínez-Rojas
    • Esther Giraldo
    • Victoria Moreno-Manzano

    Original Article Open access 29 July 2022 Article: 455

    

15. Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes

    • Sunisa Yoodee
    • Paleerath Peerapen
    • Visith Thongboonkerd

    Original Article 28 July 2022 Article: 454

    

16. Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses

    • Shiden Solomon
    • Nirmal Kumar Sampathkumar
    • Jacqueline C Mitchell

    Original Article Open access 27 July 2022 Article: 453

    

17. Endoplasmic reticulum stress contributes to cisplatin-induced chronic kidney disease via the PERK–PKCδ pathway

    • Shaoqun Shu
    • Hui Wang
    • Zheng Dong

    Original Article 27 July 2022 Article: 452

    

18. From resveratrol to ISIDE11: how to activate SIRT1 and improve endothelial function? New therapeutic insights for methylenetetrahydrofolate reductase deficiency

    • Stanislovas S. Jankauskas
    • Pasquale Mone
    • Gaetano Santulli

    Commentary 27 July 2022 Article: 451

19. Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies

    • Altair B. Dos Santos
    • Line K. Skaanning
    • Kristi A. Kohlmeier

    Original Article 26 July 2022 Article: 450

    

20. Lighting up Nobel Prize-winning studies with protein intrinsic disorder

    • Lolita Piersimoni
    • Marina Abd el Malek
    • Vladimir N. Uversky

    Review 26 July 2022 Article: 449

    

21. Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors

    • Verena Schmid
    • Alexander Wurzel
    • Ulrike Friedrich

    Original Article Open access 25 July 2022 Article: 448

    

22. The role of BMP4 signaling in trophoblast emergence from pluripotency

    • R. Michael Roberts
    • Toshihiko Ezashi
    • Mana M. Parast

    Review 25 July 2022 Article: 447

    

23. APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b

    • Giulia Antoniali
    • Emiliano Dalla
    • Gianluca Tell

    Original Article Open access 25 July 2022 Article: 446

    

24. Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage

    • Haibin Deng
    • Yanyun Gao
    • Thomas Michael Marti

    Original Article Open access 25 July 2022 Article: 445

    

25. A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5

    • Nora Klinke
    • Heiko Meyer
    • Achim Paululat

    Original Article Open access 22 July 2022 Article: 444

    

26. Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7

    • Jinbiao Chen
    • Yang Zhao
    • Geoffrey W. McCaughan

    Original Article Open access 22 July 2022 Article: 443

    

27. Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B

    • Katia Fettucciari
    • Flavien Marguerie
    • Gabrio Bassotti

    Original Article Open access 22 July 2022 Article: 442

    

28. Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model

    • Camille Januel
    • Giovanna Menduti
    • Marina Boido

    Original Article Open access 22 July 2022 Article: 441

    

29. Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system

    • Stefan Peischard
    • Melina Möller
    • Guiscard Seebohm

    Original Article Open access 21 July 2022 Article: 440

    

30. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia

    • Ke Wang
    • Chenran Wang
    • Yanqin Gao

    Original Article Open access 21 July 2022 Article: 439

    

31. H₂S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine

    • Maria Petrosino
    • Karim Zuhra
    • Tomas Majtan

    Original Article Open access 21 July 2022 Article: 438

    

32. Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB

    • E. D’Acunto
    • L. Gianfrancesco
    • E. Miranda

    Original Article Open access 21 July 2022 Article: 437

    

33. Alternations of gene expression in PI3K and AR pathways and DNA methylation features contribute to metastasis of prostate cancer

    • Yue Zhao
    • Xin Hu
    • Chen Shao

    Original Article 21 July 2022 Article: 436

    

34. C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells

    • Xiuyuan Chen
    • Yucheng Ji
    • Lifeng Lao

    Original Article 21 July 2022 Article: 435

    

35. ISG15 as a prognostic biomarker in solitary fibrous tumour

    • Jose L. Mondaza-Hernandez
    • David S. Moura
    • Javier Martin-Broto

    Original Article Open access 21 July 2022 Article: 434

    

36. How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation

    • Stephen J. Renaud
    • Mariyan J. Jeyarajah

    Review 20 July 2022 Article: 433

    

37. Activation of the hypoxia response protects mice from amyloid-β accumulation

    • Teemu Ollonen
    • Margareta Kurkela
    • Peppi Koivunen

    Original Article Open access 19 July 2022 Article: 432

    

38. Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice

    • Eléonore Bertin
    • Audrey Martinez
    • Eric Boué-Grabot

    Original Article Open access 19 July 2022 Article: 431

    

39. Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations

    • Mengna Peng
    • Rui Sun
    • Gelin Xu

    Original Article 18 July 2022 Article: 430

    

40. Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation

    • Gyan Prakash Mishra
    • Atimukta Jha
    • Sunil Kumar Raghav

    Original Article Open access 18 July 2022 Article: 429

    

41. Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology

    • Vincenzo Zara
    • Graziana Assalve
    • Alessandra Ferramosca

    Review Open access 17 July 2022 Article: 428

    

42. Pan-sarcoma characterization of lncRNAs in the crosstalk of EMT and tumour immunity identifies distinct clinical outcomes and potential implications for immunotherapy

    • Deyao Shi
    • Shidai Mu
    • Jianxiang Liu

    Original Article 16 July 2022 Article: 427

    

43. Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis

    • Alexander V. Zhdanov
    • Anna V. Golubeva
    • Dmitri B. Papkovsky

    Original Article Open access 16 July 2022 Article: 426

    

44. The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses

    • Philippe Roingeard
    • Sébastien Eymieux
    • Emmanuelle Blanchard

    Review 16 July 2022 Article: 425

    

45. ‘Youthful’ phenotype of c-Kit⁺ cardiac fibroblasts

    • Fareheh Firouzi
    • Oscar Echeagaray
    • Mark A. Sussman

    Original Article 16 July 2022 Article: 424

    

46. ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2

    • Kerstin Huebner
    • Katharina Erlenbach-Wuensch
    • Regine Schneider-Stock

    Original Article Open access 15 July 2022 Article: 423

    

47. Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis

    • Yuan-Jing Zou
    • Meng-Meng Shan
    • Shao-Chen Sun

    Original Article 14 July 2022 Article: 422

    

48. Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates

    • Francesco Caligiore
    • Erika Zangelmi
    • Alessio Peracchi

    Original Article Open access 14 July 2022 Article: 421

    

49. Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation

    • Chia-Chun Chang
    • Min Peng
    • Ji-Long Liu

    Original Article 14 July 2022 Article: 420

    

50. Human myelin proteolipid protein structure and lipid bilayer stacking

    • Salla Ruskamo
    • Arne Raasakka
    • Petri Kursula

    Original Article Open access 12 July 2022 Article: 419