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Global phosphoproteomic analysis identified key kinases regulating male meiosis in mouse Haojie LiHong ChenXuejiang Guo Original Article 05 August 2022 Article: 467
Sample-multiplexing approaches for single-cell sequencing Yulong ZhangSiwen XuXinghua Pan Review 05 August 2022 Article: 466
Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels Hamza MameriGéraldine Buhagiar-LabarchèdeMounira Amor-Guéret Original Article Open access 04 August 2022 Article: 465
Evolution and molecular interactions of major histocompatibility complex (MHC)-G, -E and -F genes Antonio Arnaiz-VillenaFabio Suarez-TrujilloJosé Manuel Martin-Villa Review Open access 04 August 2022 Article: 464
Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations Angelique CercillieuxEleonora CiarloCarles Canto Review Open access 02 August 2022 Article: 463
α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation Yasuteru InoueMasayoshi TasakiMitsuharu Ueda Original Article 02 August 2022 Article: 462
USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection Phatcharida JantareeSupattra ChaithongyotMichael Naumann Original Article Open access 01 August 2022 Article: 461
5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism Ling HuangJunping ZhengHongtao Liu Original Article 01 August 2022 Article: 460
Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors Li LiuDmytro KryvokhyzhaKarl Swärd Original Article Open access 01 August 2022 Article: 459
Adult neurogenesis of the median eminence contributes to structural reconstruction and recovery of body fluid metabolism in hypothalamic self-repair after pituitary stalk lesion Yichao OuMingfeng ZhouSongtao Qi Original Article 30 July 2022 Article: 458
Aβ1-42 peptides blunt the adenosine A2A receptor-mediated control of the interplay between P2X7 and P2Y1 receptors mediated calcium responses in astrocytes Liliana DiasDaniela MadeiraPaula Agostinho Original Article 30 July 2022 Article: 457
Metabolic reprogramming consequences of sepsis: adaptations and contradictions Jingjing LiuGaosheng ZhouDawei Liu Review 29 July 2022 Article: 456
NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation Beatriz Martínez-RojasEsther GiraldoVictoria Moreno-Manzano Original Article Open access 29 July 2022 Article: 455
Roles of heat-shock protein 90 and its four domains (N, LR, M and C) in calcium oxalate stone-forming processes Sunisa YoodeePaleerath PeerapenVisith Thongboonkerd Original Article 28 July 2022 Article: 454
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses Shiden SolomonNirmal Kumar SampathkumarJacqueline C Mitchell Original Article Open access 27 July 2022 Article: 453
Endoplasmic reticulum stress contributes to cisplatin-induced chronic kidney disease via the PERK–PKCδ pathway Shaoqun ShuHui WangZheng Dong Original Article 27 July 2022 Article: 452
From resveratrol to ISIDE11: how to activate SIRT1 and improve endothelial function? New therapeutic insights for methylenetetrahydrofolate reductase deficiency Stanislovas S. JankauskasPasquale MoneGaetano Santulli Commentary 27 July 2022 Article: 451
Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α-synucleinopathies Altair B. Dos SantosLine K. SkaanningKristi A. Kohlmeier Original Article 26 July 2022 Article: 450
Lighting up Nobel Prize-winning studies with protein intrinsic disorder Lolita PiersimoniMarina Abd el MalekVladimir N. Uversky Review 26 July 2022 Article: 449
Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors Verena SchmidAlexander WurzelUlrike Friedrich Original Article Open access 25 July 2022 Article: 448
The role of BMP4 signaling in trophoblast emergence from pluripotency R. Michael RobertsToshihiko EzashiMana M. Parast Review 25 July 2022 Article: 447
APE1 controls DICER1 expression in NSCLC through miR-33a and miR-130b Giulia AntonialiEmiliano DallaGianluca Tell Original Article Open access 25 July 2022 Article: 446
Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage Haibin DengYanyun GaoThomas Michael Marti Original Article Open access 25 July 2022 Article: 445
A Drosophila melanogaster model for TMEM43-related arrhythmogenic right ventricular cardiomyopathy type 5 Nora KlinkeHeiko MeyerAchim Paululat Original Article Open access 22 July 2022 Article: 444
Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7 Jinbiao ChenYang ZhaoGeoffrey W. McCaughan Original Article Open access 22 July 2022 Article: 443
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B Katia FettucciariFlavien MarguerieGabrio Bassotti Original Article Open access 22 July 2022 Article: 442
Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model Camille JanuelGiovanna MendutiMarina Boido Original Article Open access 22 July 2022 Article: 441
Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system Stefan PeischardMelina MöllerGuiscard Seebohm Original Article Open access 21 July 2022 Article: 440
The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia Ke WangChenran WangYanqin Gao Original Article Open access 21 July 2022 Article: 439
H2S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine Maria PetrosinoKarim ZuhraTomas Majtan Original Article Open access 21 July 2022 Article: 438
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB E. D’AcuntoL. GianfrancescoE. Miranda Original Article Open access 21 July 2022 Article: 437
Alternations of gene expression in PI3K and AR pathways and DNA methylation features contribute to metastasis of prostate cancer Yue ZhaoXin HuChen Shao Original Article 21 July 2022 Article: 436
C-type lectin domain-containing protein CLEC3A regulates proliferation, regeneration and maintenance of nucleus pulposus cells Xiuyuan ChenYucheng JiLifeng Lao Original Article 21 July 2022 Article: 435
ISG15 as a prognostic biomarker in solitary fibrous tumour Jose L. Mondaza-HernandezDavid S. MouraJavier Martin-Broto Original Article Open access 21 July 2022 Article: 434
How trophoblasts fuse: an in-depth look into placental syncytiotrophoblast formation Stephen J. RenaudMariyan J. Jeyarajah Review 20 July 2022 Article: 433
Activation of the hypoxia response protects mice from amyloid-β accumulation Teemu OllonenMargareta KurkelaPeppi Koivunen Original Article Open access 19 July 2022 Article: 432
Increased surface P2X4 receptors by mutant SOD1 proteins contribute to ALS pathogenesis in SOD1-G93A mice Eléonore BertinAudrey MartinezEric Boué-Grabot Original Article Open access 19 July 2022 Article: 431
Extracellular vesicles carrying proinflammatory factors may spread atherosclerosis to remote locations Mengna PengRui SunGelin Xu Original Article 18 July 2022 Article: 430
Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation Gyan Prakash MishraAtimukta JhaSunil Kumar Raghav Original Article Open access 18 July 2022 Article: 429
Multiple roles played by the mitochondrial citrate carrier in cellular metabolism and physiology Vincenzo ZaraGraziana AssalveAlessandra Ferramosca Review Open access 17 July 2022 Article: 428
Pan-sarcoma characterization of lncRNAs in the crosstalk of EMT and tumour immunity identifies distinct clinical outcomes and potential implications for immunotherapy Deyao ShiShidai MuJianxiang Liu Original Article 16 July 2022 Article: 427
Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis Alexander V. ZhdanovAnna V. GolubevaDmitri B. Papkovsky Original Article Open access 16 July 2022 Article: 426
The double-membrane vesicle (DMV): a virus-induced organelle dedicated to the replication of SARS-CoV-2 and other positive-sense single-stranded RNA viruses Philippe RoingeardSébastien EymieuxEmmanuelle Blanchard Review 16 July 2022 Article: 425
‘Youthful’ phenotype of c-Kit+ cardiac fibroblasts Fareheh FirouziOscar EcheagarayMark A. Sussman Original Article 16 July 2022 Article: 424
ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2 Kerstin HuebnerKatharina Erlenbach-WuenschRegine Schneider-Stock Original Article Open access 15 July 2022 Article: 423
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis Yuan-Jing ZouMeng-Meng ShanShao-Chen Sun Original Article 14 July 2022 Article: 422
Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates Francesco CaligioreErika ZangelmiAlessio Peracchi Original Article Open access 14 July 2022 Article: 421
Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation Chia-Chun ChangMin PengJi-Long Liu Original Article 14 July 2022 Article: 420
Human myelin proteolipid protein structure and lipid bilayer stacking Salla RuskamoArne RaasakkaPetri Kursula Original Article Open access 12 July 2022 Article: 419