Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXaI16L in Preclinical Species Chuenlei ParngMichael BoltRob Webster Research Article 11 April 2019 Article: 52
Dissolution Chamber for Small Drug Delivery System in the Periodontal Pocket Wei RenMichael MurawskyS. Kevin Li Research Article 10 April 2019 Article: 51
CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies Jonathan P. MochelStephen C. EkkerSaad S. Kenderian Commentary 08 April 2019 Article: 50
Bacteriophage PEV20 and Ciprofloxacin Combination Treatment Enhances Removal of Pseudomonas aeruginosa Biofilm Isolated from Cystic Fibrosis and Wound Patients Rachel Yoon Kyung ChangTheerthankar DasHak-Kim Chan Research Article 04 April 2019 Article: 49
HER3-Targeted Affibodies with Optimized Formats Reduce Ovarian Cancer Progression in a Mouse Xenograft Model John S. SchardtMadeleine Noonan-ShuehSteven M. Jay Research Article 04 April 2019 Article: 48
Trial Design and Statistical Considerations on the Assessment of Pharmacodynamic Similarity Peijuan ZhuChyi-Hung HsuHonghui Zhou Research Article 03 April 2019 Article: 47
Neutralizing Antibody Assay Development with High Drug and Target Tolerance to Support Clinical Development of an Anti-TFPI Therapeutic Monoclonal Antibody Yuhong XiangChuenlei ParngJean Donley Research Article 29 March 2019 Article: 46
Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells Madhav SacharEdward J. KellyJashvant D. Unadkat Research Article 27 March 2019 Article: 45
Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective Jinjiang LiMary E. KrauseLily Zhu White Paper Open access 26 March 2019 Article: 44
Theoretical Considerations for Direct Translation of Unbound Liver-to-Plasma Partition Coefficient from In Vitro to In Vivo Zhenhong LiLi DiTristan S. Maurer Research Article 18 March 2019 Article: 43
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations Krishna K. MachavaramChihiro Endo-TsukudePatricia Sanwald Ducray Research Article 18 March 2019 Article: 42
Effect of Dibasic Calcium Phosphate Incorporation on Cellulose Nanocrystal/Chitosan Hydrogel Properties for the Treatment of Vertebral Compression Fractures Soheila Ali Akbari GhavimiEthan S. LungrenBret D. Ulery Research Article 18 March 2019 Article: 41
A Receiver Operating Characteristic Framework for Non-adherence Detection Using Drug Concentration Thresholds—Application to Simulated Risperidone Data in Schizophrenic Patients Carlos Pérez-RuixoBart RemmerieAn Vermeulen Research Article 14 March 2019 Article: 40
Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation Mohammad TabriziDivas NeupaneEnrique Escandon Research Article 13 March 2019 Article: 39
Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method E. A. M. CalvierE. H. J. KrekelsCatherijne A. J. Knibbe Research Article Open access 08 March 2019 Article: 38
Variability Attribution for Automated Model Building Moustafa M. A. IbrahimRikard NordgrenMats O. Karlsson Research Article Open access 08 March 2019 Article: 37
Dissolution Edge Charts for Immediate Release Products and Their Applications: a Simulation Study to Aid the Setting of Specifications John Z. Duan Research Article 05 March 2019 Article: 36
A Reappraisal of Sedimentation Nonideality Coefficients for the Analysis of Weak Interactions of Therapeutic Proteins Sumit K. ChaturvediPeter Schuck Research Article Open access 27 February 2019 Article: 35
Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment Moustafa M. A. IbrahimSebastian UeckertMats O. Karlsson Research Article Open access 27 February 2019 Article: 34
A Density-Changing Centrifugation Method for Efficient Separation of Free Drugs from Drug-Loaded Particulate Delivery Systems Lu HanHongyan ZhanLi Deng Research Article 25 February 2019 Article: 33
First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release Testing Nikolay ZaborenkoZhenqi ShiBrian M. Zacour White Paper Open access 21 February 2019 Article: 32