1. Estimating drug potency in the competitive target mediated drug disposition (TMDD) system when the endogenous ligand is included.

   • Begum Alaybeyoglu
   • Ho Wa (Jacky) Cheng
   • Andrew M. Stein

   Original Paper 08 February 2021 Pages: 447 - 464

   

2. A population K-PD model analysis of long-term testosterone inhibition in prostate cancer patients undergoing intermittent androgen deprivation therapy

   • Joost DeJongh
   • Maurice Ahsman
   • Nelleke Snelder

   Original Paper 04 February 2021 Pages: 465 - 477

   

3. Population pharmacokinetic characteristics of cemiplimab in patients with advanced malignancies

   • Feng Yang
   • Anne J. Paccaly
   • A. Thomas DiCioccio

   Original Paper Open access 16 March 2021 Pages: 479 - 494

   

4. Constant infusion case of one compartment pharmacokinetic model with simultaneous first-order and Michaelis–Menten elimination: analytical solution and drug exposure formula

   • Xiaotian Wu
   • Min Chen
   • Jun Li

   Original Paper 24 February 2021 Pages: 495 - 508

   

5. Reduction of quantitative systems pharmacology models using artificial neural networks

   • Abdallah Derbalah
   • Hesham S. Al-Sallami
   • Stephen B. Duffull

   Original Paper 02 March 2021 Pages: 509 - 523

   

6. A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases

   • Jacob Leander
   • Mikael Sunnåker
   • Joanna Parkinson

   Original Paper Open access 17 March 2021 Pages: 525 - 541

   

7. Optimum multi-drug regime for compartment model of tumour: cell-cycle-specific dynamics in the presence of resistance

   • Bharti Panjwani
   • Vijander Singh
   • Vijay Mohan

   Original Paper 22 March 2021 Pages: 543 - 562

   

8. Use of population PK/PD approach to model the thrombin generation assay: assessment in haemophilia A plasma samples spiked by a TFPI antibody

   • Raphaël Crépin
   • Claire Morin
   • Pierre Chelle

   Original Paper 12 April 2021 Pages: 563 - 580

   

9. Comparing the performance of first-order conditional estimation (FOCE) and different expectation–maximization (EM) methods in NONMEM: real data experience with complex nonlinear parent-metabolite pharmacokinetic model

   • Thanh Bach
   • Guohua An

   Original Paper 21 April 2021 Pages: 581 - 595

   

10. Fast screening of covariates in population models empowered by machine learning

    • Emeric Sibieude
    • Akash Khandelwal
    • Nadia Terranova

    OriginalPaper Open access 21 May 2021 Pages: 597 - 609

    

11. Correction to: Modeling the acute effects of exercise on glucose dynamics in healthy nondiabetic subjects

    • Spencer Frank
    • Abdulrahman Jbaily
    • Andrew J. Szeri

    Correction 01 June 2021 Pages: 611 - 612

12. Correction to: Abstracts for the Ninth American Conference on Pharmacometrics (ACoP9)

    Correction 11 June 2021 Pages: 613 - 614