Abstract
Living organisms especially a wide range of microbes and plants produce secondary metabolites, which prove beneficial in improving the efficiency of metabolic processes. These metabolites with unique properties are categorized as bioactive molecules (BAMs). The utility of these BAMs has found its way to almost all biological processes, such that there has been a dramatic surge in their demand. The unique characteristics can be assigned to the chemical structures and associated groups. Conventional methods for searching novel BAMs are proving counterproductive. Modern molecular biological techniques in association with bioinformatic tools have provided the much necessary boost to the morale of the scientific community. The most effective genomic tool for searching these novel BAMs are (1) sequencing of whole genomes and (2) culture-independent (metagenomic) analysis. These approaches allow generation of huge amount of information, which can be easily analyzed through bioinformatic tools.
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The author wishes to thank the director of CSIR-Institute of Genomics and Integrative Biology, Delhi, India, OLP1126 (CSIR-HRD ES21(1022)/16/EMR-II) for providing the necessary funds, facilities, and moral support.
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Kalia, V.C. (2017). Mining Metagenomes for Novel Bioactive Molecules. In: Kalia, V., Shouche, Y., Purohit, H., Rahi, P. (eds) Mining of Microbial Wealth and MetaGenomics. Springer, Singapore. https://doi.org/10.1007/978-981-10-5708-3_1
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