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Regulation of Cell Division Cycles by Circadian Oscillators: Signal Transduction Between Clocks

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Physiology and Pharmacology of Biological Rhythms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 125))

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Abstract

An important consideration for maximizing the results of radio- and chemotherapy of mammalian cancers is that of host tolerance. It is unfortunate that in most of the earlier cancer work there is little mention of the role of rhythmic variations (particularly circadian periodicities) in the susceptibility of the whole organism to the toxicity of the drug(s) being utilized for treatment (chronotolerance). There now is abundant experimental evidence, however, that properly designed protocols (such as sinusoidally varying drug courses during the 24-h day) can dramatically enhance survival and cure rates by concomitantly maximizing the tolerance of the host to the drug through a temporal shielding of normal, healthy tissues (for recent reviews, see Lemmer 1989; Tourrou and Haus 1992; Chap. 11, this volume). Thus, “when” to treat must assume importance together with the “what” and “where” (Halberg 1975) — a concept embraced by the field of chronotherapeutics.

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Authors
  1. L. N. Edmunds Jr.
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Editors and Affiliations

  1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA1 7AY, Bath, UK

    Peter H. Redfern BPharm, PhD

  2. Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    B. Lemmer (Direktor) (Direktor)

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© 1997 Springer-Verlag Berlin Heidelberg

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Edmunds, L.N. (1997). Regulation of Cell Division Cycles by Circadian Oscillators: Signal Transduction Between Clocks. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_2

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  • DOI: https://doi.org/10.1007/978-3-662-09355-9_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-08265-8

  • Online ISBN: 978-3-662-09355-9

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