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Chronobiology and Chronopharmacology of the Haemopoietic System

  • Chapter
Physiology and Pharmacology of Biological Rhythms

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 125))

Abstract

The bone marrow, an extremely complex tissue comprising approximately 4.5% of an adult’s body weight (a mass comparable to the liver) (Nathan 1988), is found in the ends of flat bones (sternum, ribs, skull, vertebrae and innominates) and contains the haemopoietic stem cells, which give rise to the many developing functional blood cell lineages within the marrow spaces. After birth, the bone marrow is the production site for all types of blood cells, which are released through vascular channels into the peripheral blood according to the needs of the body, mediated through different feedback mechanisms. Haemopoiesis is the multi-phase process of cell proliferation and gradual maturation, until the end stage is reached with a population of mature cells that can exert their specialized functions, but are no longer capable of cell proliferation (Laerum et al. 1989).

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  1. School of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA1 7AY, Bath, UK

    Peter H. Redfern BPharm, PhD

  2. Instituts für Pharmakologie und Toxikologie Fakultät für klinische Medizin Mannheim, Universität Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    B. Lemmer (Direktor) (Direktor)

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Smaaland, R. (1997). Chronobiology and Chronopharmacology of the Haemopoietic System. In: Redfern, P.H., Lemmer, B. (eds) Physiology and Pharmacology of Biological Rhythms. Handbook of Experimental Pharmacology, vol 125. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09355-9_18

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