Skip to main content
SpringerLink
Log in

The Marburg Experiment

  • Chapter
Principles and Practice of Research

Abstract

The view that clinical research is always less “scientific”, and therefore less valuable than biomedical research, reflects considerable prejudice. The fact that the clinician who takes care of patients cannot devote all his professional life to research is not, in itself, valid grounds for depreciating the quality of clinical science. Such value judgments based on any epistemiological model (1–4), are only valid and fair when the work of full-time investigators in clinical disciplines is compared with that of full-time basic research scientists.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lakatos I, Musgrave A, Editors. Criticism and the growth of knowledge. Cambridge-London-New York: Cambridge University Press, 1975: 1–282.

    Google Scholar 

  2. Stachowiak H. Medizin als handlungswissenschaft. In Gross R, editor. Modelle und realitaten in der medizin, schattauer verlag. Stuttgard-New York: 1983: 7–22.

    Google Scholar 

  3. Stegmuller W. Theoriendynamik. Normale wissenschaft und wissenschaftliche revolutionen. Methodologie der forschungsprogramme oder epistemologische anarchie? In Probleme und resultate der wissenschaftstheorie und analytischen philosophie. Band II. Theorie und Erfahrung. Berlin-Heidelberg-New York: Springer Verlag, 1973: 153–327.

    Google Scholar 

  4. Feyerabend PK. Wie wird man ein braver empirist? Ein aufruf zur toleranz in der erkenntnistheorie (how to be a good empiricist—a plea for tolerance in matters epidemiological). In Kruger L, editor. Erkenntnis-Probleme der Naturwissenschaften, Kiepenheuer—Witsch. Koln-Berlin: 1970: 302–335.

    Google Scholar 

  5. Lorenz W, Hamelmann H, Troidl H. Marburg experiment on surgical research: a five-year experience on the cooperation between clinical and theoretical surgeons. Klin Wschr 1976; 54: 927–936.

    Article  PubMed  CAS  Google Scholar 

  6. Lorenz W, Roher HD. Fifteen years of the Marburg Experiment on surgical research. Part I: change from experimental to theoretical surgery. Theor Surg 1986; 1: 21–31.

    Google Scholar 

  7. Lorenz W. The progress of surgical science. Lancet II. 1983: 1017–1017.

    Google Scholar 

  8. Lorenz W, Roher HD. Entwicklung wissenschaftlicher Aussagen. In Schreiber HW, Carstensen G, editors. Chirurgie im Wandel der Zeit 1945–1983. Berlin-Heidelberg: Springer Verlag, 1983: 28–35.

    Chapter  Google Scholar 

  9. Rohde H, Troidl H, Lorenz W. Systematic follow-up: a concept for evaluation of operative results in duodenal ulcer patients. Klin Wschr 1977; 55: 925–932.

    Article  PubMed  CAS  Google Scholar 

  10. Troidl H, Lorenz W, Rohde H, Fischer M, Ves-tweber KH, Hamelmann H. Trends in der Chirurgie des chronischen ulces duodeni: eine prospektive kontrollierte aber noch immer nicht randomisierte Studie. Chirurg 1979; 50: 285–290.

    PubMed  CAS  Google Scholar 

  11. Lorenz W, Ohmann CH. Methodische Formen klinischer Studien in der Chirurgie: indikation und bewertung. Chirurg 1983; 54: 189–195.

    PubMed  CAS  Google Scholar 

  12. Allgower M. Interdisziplinare Zusammenarbeit in der Chirurgie. Ther Umsch 1972; 29: 645.

    PubMed  CAS  Google Scholar 

  13. Lorenz W. Attitudes to controlled clinical trials. Lancet I 1982: 1460–1461.

    Google Scholar 

  14. Lorenz W, Doenicke A, Meyer R, et al. An improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone. Europ J Pharmacol 1972; 19: 180–190.

    Article  CAS  Google Scholar 

  15. Lorenz W, Benesch L, Barth H, et al. Fluoro-metric assay of histamine in tissues and body fluids: choice of the purification procedure and identification in the nanogram range. Z Analyt Chem 1970; 252: 94–98.

    Article  CAS  Google Scholar 

  16. Doenicke A, Lorenz W. Histaminfreisetzung und anaphylaktische reaktionen bei narkosen. Biochemische und Klinische Aspekte. Anaesthesist 1970; 19: 413–417.

    PubMed  CAS  Google Scholar 

  17. Lorenz W, Reimann H-J, Barth H, et al. A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe-Seyler’s Z Physiol Chem 1972; 353: 911–920.

    Article  PubMed  CAS  Google Scholar 

  18. Beaven MA, WoldeMussie E. Histamine in body fluids: its measurement in different clinical states. NER Allergy Proc 1984; 5: 300–310.

    Article  CAS  Google Scholar 

  19. Moss J, Rosow CE, Savarese JJ, Philbin DM, Kniffen KJ. Role of histamine in the hypotensive action of d-tubocurarine in humans. Anesthesiology 1981; 55: 19–25.

    Article  PubMed  CAS  Google Scholar 

  20. Moss J, Rosow CE. Histamine release by narcotics and muscle relaxants in human. Anesthesiology 1983; 59: 330–338.

    Article  PubMed  CAS  Google Scholar 

  21. Lorenz W, Doenicke A, Meyer R, et al. Histamine release in man by propanidid and thiopentone: pharmacological effects and clinical consequences. Brit J Anaesth 1972; 44: 355–369.

    Article  PubMed  CAS  Google Scholar 

  22. Doenicke A, Lorenz W, Beigi R, et al. Histamine release after intravenous application of short-acting hypnotics: a comparison of etomidate, althesin (CT 1341) and Propanidid. Brit J Anaesth 1973; 45: 1097–1104.

    Article  PubMed  CAS  Google Scholar 

  23. Lorenz W, Roher HD, Doenicke A, Ohmann CH. Histamine release in anaesthesia and surgery: a new method to evaluate its clinical significance with several types of causal relationship. Clin an-aesthesiol 1984; 2: 403–426.

    Google Scholar 

  24. Lorenz W, Seidel W, Doenicke A, et al. Elevated plasma histamine concentrations in surgery: causes and clinical significance. Klin Wschr 1974; 52: 419–425.

    Article  PubMed  CAS  Google Scholar 

  25. Watkins J. Etomidate: An “immunologically safe” anaesthetic agent. Anaesthesia 1983; 38: 34–38.

    Article  PubMed  CAS  Google Scholar 

  26. Troidl H, Lorenz W, Barth H, et al. Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine: inhibition of histamine methyltransferase in vivo? Agents Actions 1973; 3: 157–167.

    Article  PubMed  CAS  Google Scholar 

  27. Seidel W, Troidl H, Lorenz W, et al. Eine prospektive, kontrollierte Studie zur selektiven va-gotomie beim chronischen duodenalulkus: fru-hergebnisse mit einer standardisierten operationsauswahl u. operationstechnik. Klin Wschr 1973; 51: 477–486.

    Article  Google Scholar 

  28. Rohde H, Lorenz W, Troidl H, Reimann H-J, Hafner G, Weber D. Histamine and peptic ulcer: influence of sample-taking on the precision and accuracy of fluorometric histamine assay in biopsies of human gastric mucosa. Agents Actions 1980; 10: 175–185.

    Article  CAS  Google Scholar 

  29. Troidl H, Lorenz W, Rohde H, Hafner G, Ron-zheimer M. Histamine and peptic ulcer: a prospective study of mucosal histamine concentrations in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases. Klin Wschr 1976; 54: 947–956.

    Article  PubMed  CAS  Google Scholar 

  30. Barth H, Troidl H, Lorenz W, Rohde H, Glass R. Histamine and peptic ulcer disease: histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment. Agents Actions 1977; 7: 75–79.

    Article  PubMed  CAS  Google Scholar 

  31. Troidl H, Rohde H, Lorenz W, Hafner G, Hamelmann H. Effect of selective gastric vagotomy on histamine concentration in gastric mucosa of patients with duodenal ulcer. Brit J Surg 1978; 65: 101–16.

    Article  Google Scholar 

  32. Man WK, Saunders JH, Ingoldby C, Spencer J. Effect of selective gastric vagotomy on histamine concentration in gastric mucosa of control subjects and duodenal ulcer patients before and after surgical treatment. Agents Actions 1977; 7: 75–79.

    Article  Google Scholar 

  33. Lorenz W, Thon K, Barth H, Neugebauer E, Reimann H-J, Kuschej. Metabolism and function of gastric histamine in health and disease. J Clin Gastroenterol 1983; 5 (suppl. l): 37–56.

    Article  PubMed  Google Scholar 

  34. Hansen JH, Knigge U. Failure of proximal gastric vagotomy for duodenal ulcer resistant to Cimetidine. Lancet 1984; 11: 84–86.

    Article  Google Scholar 

  35. Lorenz W, Thon K, Ohmann CH, Roher HD. Symptomloses und kompliziertes ulcus pepticum als extreme erscheinungsformen der ulcuskran-kheit: konsequenzen fur die wähl zwischen konservativer und chirurgischer therapie. Langen-becks Arch. Chir 1985; 366: 69–79.

    Article  CAS  Google Scholar 

  36. Messmer K, Lorenz W, Haendle H, Klovekorn WP, Hutzel M. Acute hypotension and histamine liberation following rapid infusion of plasma substitutes in dogs. Europ Surg Res 1969; 1: 188–189.

    Google Scholar 

  37. Goth A. Histamine release by drugs and chemicals. In Histamine and antihistamines, International Encyclopedia of Pharmacology and Therapeutics, vol 1, Oxford-New York-Toronto- Sydney-Braunschweig: Pergamon Press, 1973: 25–43.

    Google Scholar 

  38. Keller R. A study of the mastocytolytic effects of polycations in the presence of certain plasma substitutes. Bibl Haemat 1969; 33: 126–130.

    PubMed  CAS  Google Scholar 

  39. Messmer K, Lorenz W, Sunder-Plassmann L, Kloevekorn WP, Hutzel M. Histamine release as cause of acute hypotension following rapid colloid infusion. Naunyn-Schmiedebergs Arch. Pharmak 1970; 267: 433–445.

    Article  CAS  Google Scholar 

  40. Lorenz W, Doenicke A, Messmer K, et al. Histamine release in human subjects by modified gelatin (Haemaccel (R)) and dextran: an explanation for anaphylactoid reactions observed under clinical conditions? Brit J Anaesth 1976; 48: 151–165.

    Article  PubMed  CAS  Google Scholar 

  41. Lorenz W, Doenicke A, Schöning B, Karges H, Schmal A. Incidence and mechanisms of adverse reactions to polypeptides in man and dog. In Hennessen W, editor. Joint WHO/IABS symposium on the standardization of albumin, plasma substitutes and plasmapheresis, Geneva 1980. Develop. Biol. Standard. 48. Karger Verlag 1981: 207–234.

    Google Scholar 

  42. Williams JG, Riley TRD, Moody RA. Resuscitation experience in the Falkland Islands Campaign. Brit Med J 1983; 286: 775–777.

    Article  CAS  Google Scholar 

  43. Bennet JR, Dykes PW. Ulcerative disease of the stomach and the duodenum. In Dykes PW, Keighly MRB, editors. Gastrointestinal Haemorrhage, John Wright, Bristol. 1981: 155–165.

    Google Scholar 

  44. DeDombal FT, Morgan AG, Staniland JR, Ohmann C. Clinical features computer analysis. In Dykes PW, Keighley MRB, editors. Gastrointestinal haemorrhage, John Wright Bristol. 1981: 155–165.

    Google Scholar 

  45. Thon K, Ohmann CH, Stoltzing H, Lorenz W. Medical decision making in upper gastrointestinal bleeding: the impact of clinical criteria for the diagnosis of recurrent haemorrhage. Theor Sur 1986; 1: 32–39.

    Google Scholar 

  46. Ohmann CH, Thon K, Stoltzing H, Lorenz W. Medical decision making for monitoring patients with upper gastrointestinal bleeding. In van Bem-mel JH, Gremy F, Zvarova J, editors. Medical decision making: Diagnostic strategies and experts systems. North-Holland: Elsevier Science Publishers B.V., 1985: 136–139.

    Google Scholar 

Download references

Authors
  1. W. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Troidl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Cologne Surgical Clinic Merheim, D-5000, Cologne 91, Federal Republic of Germany

    Hans Troidl

  2. Department of Epidemiology and Biostatistics, McGill University, H3A 1A2, Montreal, Quebec, Canada

    Walter O. Spitzer

  3. Department of Anaesthesia, Harvard University Massachusetts General Hospital, 02114, Boston, Massachusetts, USA

    Bucknam McPeek

  4. Department of Surgery, McGill University Montreal General Hospital, H3G 1A4, Montreal, Quebec, Canada

    David S. Mulder

  5. Division of Cardio-Thoracic Surgery, Albany Medical College of Union University, 12208, Albany, New York, USA

    Martin F. McKneally

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Lorenz, W., Troidl, H. (1986). The Marburg Experiment. In: Troidl, H., Spitzer, W.O., McPeek, B., Mulder, D.S., McKneally, M.F. (eds) Principles and Practice of Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96942-3_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-96942-3_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96944-7

  • Online ISBN: 978-3-642-96942-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation