Skip to main content
SpringerLink
Log in

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

Histamin und Ulkuskrankheit

  • Symposion On Gastric And Duodenal Ulcer Disease. Marburg 1975
  • The Surgeon's View
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Zusammenfassung

In einer prospektiven Studie wurde der Histamingehalt der Korpusschleimhaut bei 100 Patienten gemessen. Diese Patienten schließen Kontrollpersonen, Ulkus-duodeni-Träger und solche mit verschiedenen gastrointestinalen Erkrankungen ein. Der Histamingehalt betrug 43 µg/g bei Kontrollpersonen und war bei Ulkus-duodeni-Kranken signifikant um 30% erniedrigt. Alle anderen Patientengruppen wiesen „normale“ Histamingehalte in der Magenschleimhaut auf. Da es bei allen Säugerarten mit Ausnahme der Ratte äußerst schwierig ist, den Histamingehalt der Magenschleimhaut durch irgendeine Maßnahme zu verändern, erscheint die Abnahme des Histamingehaltes der Korpusschleimhaut beim Ulkus duodeni besonders bemerkenswert. Unter verschiedenen Hypothesen gilt als wahrscheinlichste eine vermehrte Histaminfreisetzung beim chronischen Ulkus duodeni.

Summary

In a prospective study the histamine content of the mucosa of the body of the stomach was measured in 100 patients consisting of control subjects, patients with duodenal ulcer and patients suffering from various gastrointestinal diseases. The histamine content was found to be 43 µg/g in male control subjects (median) while in duodenal ulcer patients levels attained were significantly lower by about 30 per cent. In all the other groups of patients histamine concentrations in gastric mucosa were found to be “normal”. Since in most species it is extremely difficult to alter the mucosal histamine concentration by any form of treatment, the diminished histamine content of the gastric mucosa in patients with duodenal ulcer seems remarkable. Among several possible explanations offered for this finding we think the most likely is that histamine release is increased in duodenal ulcer disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Aures, D., Håkanson, R., Schauer, A.: Histidine decarboxylase and DOPA decarboxylase in the rat stomach. Properties and cellular localization. Europ. J. Pharmacol.3, 217 (1968)

    Article  CAS  Google Scholar 

  2. Babkin, B.P.: Secretory mechanisms of the digestive glands, P.B. Hoeber, New York, 1950, p. 547

    Google Scholar 

  3. Barth, H., Lorenz, W., Troidl, H.: Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion. Brit. J. Pharmacol.55, 321 (1975)

    Article  CAS  Google Scholar 

  4. Barth, H., Niemeyer, I., Lorenz, W.: Studies on the mode of action of histamine H1- and H2-receptor antagonists on gastric histamine methyltransferase. Agents and Actions3, 138 (1973)

    Article  CAS  PubMed  Google Scholar 

  5. Barth, H., Niemeyer, I., Lorenz, W.: Studies on the mechanism of inhibition of gastric histamine methyltransferase by H1- and H2-receptor antagonists. In: Int. Symp. on Histamine H2-Receptor Antagonists, C.J. Wood, M.A. Simkins, (eds.), Deltakos (UK), London, p. 115 (1973a)

  6. Barth, H., Troidl, H., Lorenz, W., Rohde, H.: Histamine and peptic ulcer disease: Histamine methyltransferase activity in gastric mucosa of control subjects and duodenal ulcer patients Agents and Actions (in press) (1977)

  7. Black, J.W., Duncan, W.A.M., Durant, G.J., Ganellin, C.R., Parsons, M.E.: Definition and antagonism of histamine H2-receptors. Nature (London)236, 385 (1972)

    Article  CAS  PubMed  Google Scholar 

  8. Black, J.W., Duncan, W.A.M., Emmett, J.C., Ganellin, C.R., Hessellbo, T., Parsons, M.E., Wyllie, J.H.: Metiamide—an orally active histamine H2-receptor antagonist. Agents and Actions3, 133 (1973)

    Article  CAS  PubMed  Google Scholar 

  9. Büchner, F., Siebert, P., Molloy, P.J.: Über experimentell erzeugte akute peptische Geschwüre des Rattenvormagens. Beitr. pathol. Anat.81, 391 (1928/1929)

    Google Scholar 

  10. Dragstedt, L.R.: Section of the vagus nerves to the stomach in the treatment of duodenal ulcer. In: Surgery of the stomach and duodenum (Harkins, H.N., Nyhus, L.M. (eds.)), Little, Brown and Company, Boston, p. 461 (1962)

    Google Scholar 

  11. Earlam, R.: Clinical tests of oesophageal function. Crosby Lockwood Staples, London, p. 342 (1976)

    Google Scholar 

  12. Ellison, E.H., Wilson, O.: The Zollinger-Ellison Syndrome: Re-appraisal and evaluation of 260 registered cases. Ann. Surg.160, 512 (1964)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Fielding, L.P., Curwain, B.P., Russell, R.C.G., Bloom, S.: Evidence for separate actions of an adrenergicβ 2 stimulant and an histamine-H2 blocker on the oxyntic and gastrin cells. Brit. J. Surg.62, 157 (1975)

    CAS  PubMed  Google Scholar 

  14. Goligher, J.C., Pulvertaft, C.N., Irvin, T.T., Johnston, D., Walker, B., Hall, R.A., Willson-Pepper, J., Matheson, T.S.: Five to eight years results of truncal vagotomy and pyloroplasty for duodenal ulcer. Brit. med. J.I, 7 (1972)

    Article  Google Scholar 

  15. Grossman, M.I., Konturek, S.J.: Inhibition of acid secretion in dog by metiamide a histamine antagonist acting on H2-receptors. Intern. Symp. on Histamine H2-receptor Antagonists (Wood, C.J. and Simkins, M.A. (eds.), Deltakos (UK) ltd., London), 1973, p. 297

    Google Scholar 

  16. Guth, P.H., Hall, P.: Microcirulatory and mast cell changes in restraint induced gastric ulcer. Gastroenterology50, 562 (1966)

    CAS  PubMed  Google Scholar 

  17. Guth, P.H., Kozbur, X.: Pathogenesis of gastric microcirculatory and mast cell changes in restraint stress. Amer. J. dig. Dis.13, 530 (1968)

    Article  CAS  PubMed  Google Scholar 

  18. Guth, P.H., Kozbur, X.: Microcirculatory and mast cell changes in restraint stress. Amer. J. dig. Dis.14, 113 (1969)

    Article  CAS  PubMed  Google Scholar 

  19. Harris, G.W., Jacobson, D., Kahlson, G.: The occurrence of histamine in cerebral regions related to the hypophysis. Ciba found. Coll. on Endocr.4, 186 (1952)

    Google Scholar 

  20. Håkanson, R., Owman, Ch., Sjöberg, N.-O., Sporrong, B.: Amine mechanisms in enterochromaffin and enterochromaffinlike cells of gastric mucosa in various mammals. Histochemie21, 189 (1970)

    Article  PubMed  Google Scholar 

  21. Håkanson, R., Lilja, B., Owman, Ch.: Cellular localization of histamine and monoamines in the gastric mucosa of man. Histochemie18, 74 (1969)

    Article  PubMed  Google Scholar 

  22. Håkanson, R., Lilja, B., Owman, Ch.: Properties of a new system of amine-storing cells in the gastric mucosa of the rat. Europ. J. Pharmacol.1, 188 (1967)

    Article  Google Scholar 

  23. Heinkel, K., Tomat, E., Henning, N.: Meßergebnisse über die Dicke der Magenfundusschleimhaut im bioptischen Material. Klin. Wschr.38, 1032 (1960)

    Article  CAS  PubMed  Google Scholar 

  24. Hirvonen, J., Kamppuri, V., Räsänen, T.: Inhibition of vagally stimulated gastric secretion after mucosal mast cell degranulation. Acta physiol. scand.70, 236 (1967)

    Article  CAS  PubMed  Google Scholar 

  25. Johnson, L.R.: Control of gastric secretion: no room for histamine? Gastroenterology61, 106 (1971)

    CAS  PubMed  Google Scholar 

  26. Kahlson, G., Rosengren, E., Svahn, D., Thunberg, R.: Mobilization and formation of histamine in the gastric mucosa as related to acid secretion. J. Physiol. (London)174, 400 (1964)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Kahlson, G., Rosengren, E., Thunberg, R.: Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation. J. Physiol. (London)190, 455 (1967)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Konturek, S.J., Demitrescu, T., Radecki, T., Dembinski, A.: Effect of metiamide, a histamine H2-receptor antagonist on gastric and pancreatic secretion and peptic ulcers induced by histamine and pentagastrin in cats. Intern. Symp. on Histamine H2-Receptor Antagonists, C.J. Wood, M.A. Simkins (eds.),, Deltakos (UK) Ltd., London, 1973, p. 247

    Google Scholar 

  29. Kobayashi, S., Kasugai, T.: Endoscopic and biopsy criteria for the diagnosis of esophagitis with a fiberoptic esophagoscope. Amer. J. dig. Dis.19, 345 (1974)

    Article  CAS  PubMed  Google Scholar 

  30. Lorenz, W.: Histamine release in man. Agents and Actions5, 402 (1975)

    Article  CAS  PubMed  Google Scholar 

  31. Lorenz, W., Pfleger, K.: Stoffwechsel und physiologische Funktion von Histamin im Magen. Klin. Wschr.46, 57 (1968)

    Article  CAS  Google Scholar 

  32. Lorenz, W., Bennesch, L., Barth, H., Matejka, E., Meyer, R., Kusche, J., Hutzel, M., Werle, E.: Fluorometric assay of histamine in tissues and body fluids: choice of the purification procedure and identification in the nanogram range. Z. anal. Chem.252, 94 (1970)

    Article  CAS  Google Scholar 

  33. Lorenz, W., Schauer, A., Reimann, H.-J.: Biochemical and histochemical studies on the histamine stores in the pig. Naunyn-Schmiedebergs Arch. Pharmakol.269, 416 (1971)

    Google Scholar 

  34. Lorenz, W., Doenicke, A., Meyer, R., Reimann, H.-J., Kusche, J., Barth, H., Geesing, H., Hutzel, M., Weissenbacher, G.: Histamine release in man by propanidid and thiopentone: Pharmacological effects and clinical consequences. Brit. J. Anaesth.44, 355 (1972)

    Article  CAS  PubMed  Google Scholar 

  35. Lorenz, W., Reimann, H.-J., Barth, H., Kusche, J., Meyer, R., Doenicke, A., Hutzel, M.: A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe-Seylers Z. physiol. Chem.353, 911 (1972a)

    Article  CAS  PubMed  Google Scholar 

  36. Lorenz, W., Matejka, E., Schmal, A., Seidel, W., Reimann, H.-J., Uhlig, R., Mann, G.: A phylogenetic study on the occurrence and distribution of histamine in the gastrointestinal tract and other tissues of man and various animals. Comp. gen. Pharmacol.4, 229 (1973)

    Article  CAS  PubMed  Google Scholar 

  37. Lorenz, W., Thermann, M., Hamelmann, H., Schmal, A., Maroske, D., Reimann, H.-J., Kusche, J., Schingale, F., Dormann, P., Keck, P.: Influence of H1- and H2-receptor antagonists on the effects of histamine in the circulatory system and on plasma histamine levels. Int. Symp. on Histamine H2-Receptor Antagonists (C.J. Wood, M.A. Simkins (eds.)), Deltakos (UK), London, p. 151 (1973a)

    Google Scholar 

  38. Lorenz, W., Seidel, W., Doenicke, A., Tauber, R., Reimann, H.-J., Uhlig, R., Mann, G., Dormann, P., Schmal, A., Häfner, G., Hamelmann, H.: Elevated plasma histamine concentrations in surgery: Causes and clinical significance. Klin. Wschr.52, 419 (1974)

    Article  CAS  PubMed  Google Scholar 

  39. Lorenz, W., Barth, H., Thermann, M., Schmal, A., Dormann, P., Niemeyer, I.: Fluorometric histamine determination in canine plasma at normal conditions, following application of exogenous histamine and during histamine release by Haemaccel®. Hoppe-Seylers Z. physiol. Chem.355, 1097 (1974a)

    Article  CAS  PubMed  Google Scholar 

  40. Lorenz, W., Thermann, M., Messmer, K., Schmal, A., Dormann, P., Kusche, J., Barth, H., Tauber, R., Hutzel, M., Mann, G., Uhlig, R.: Elevation of histamine elimination curves in plasma and whole blood of several circulatory regions: a method for studying kinetics of histamine release in the whole animal. Agents and Actions4, 336 (1974b)

    Article  CAS  PubMed  Google Scholar 

  41. Lorenz, W., Troidl, H., Rohde, H., Häfner, G.: Histamine content in human gastric mucosa: reliability of its determination in biopsy specimens. Abstr. 6th Intern. Congress of Pharmacology, Helsinki (1975), R 20

  42. Lorenz, W., Troidl, H., Schulz, S., Becker, H., Dormann, P., Schmal, A., Meyer, R., Kusche, J., Barth, H., Rohde, H.: Stimulus-secretion coupling in the human and canine stomach: role of histamine Intern. Conf. on Stimulus-secretion coupling in the Gastrointestinal Tract, (R.M. Case and H. Goebell (eds.), MTP press, Lancaster 1976 p. 177

    Google Scholar 

  43. Lorenz, W., Hamelmann, H., Troidl, H.: Surgical research in Marburg: A five-year experience of cooperation between clinical and theoretical surgeons. Klin. Wschr.54, 927 (1976a)

    Article  CAS  PubMed  Google Scholar 

  44. Lorenz, W., Rohde, H., Troidl, H., Schwarz, B., Schmal, A.: Histamine determination in biopsy specimens of human gastric mucosa. Hoppe-Seylers Z. physiol. Chem. (in preparation) (1976b)

  45. Lorenz, W., Barth, H., Kusche, J., Troidl, H., Rohde, H., Schmal, A., Stenner, W., Nusimé, H., Häfner, G., Glass, R., Friedrich, A.: A critical review concerning metabolism and physiological function of histamine in the gastric mucosa. Satellite Symp. on Gastrointestinal Hormones, Krakow, October 1974 (in press) (1976c)

  46. Lundell, L.: Acid secretion and mobilization of gastric mucosal histamine on combined cholinergic and pentagastrin stimulation. Agents and Actions4, 211 (1974)

    Article  CAS  PubMed  Google Scholar 

  47. Multicentre Trial: Treatment of duodenal ulcer by metiamide. Lancet ii, 779 (1975)

  48. Murray, J.G., Whyllie, J.H.: Distribution of histamine, 5-hydroxy-tryptamine, and other pharmacologically active substances in the human stomach. Gut5, 530 (1964)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Räsänen, T.: Tissue eosinophils and mast cells in the human stomach wall in normal and pathological conditions. Acta path. microbiol. scand. Suppl.129, 1 (1958)

    Google Scholar 

  50. Rohde, H., Troidl, H., Lorenz, W.: Assessment of a series of defined attributes and parameters before and after vagotomy: A concept for evaluation of operative results in duodenal ulcer patients. Europ. Surg. Res. (in press) 1976a

  51. Rohde, H., Lorenz, W., Troidl, H., Reimann, H.-J., Häfner, G.: Precision and accuracy of histamine determination in human biopsy specimens. Clin. chim. Acta (in preparation) (1976b)

  52. Sachs, L.: Angewandte Statistik. Planung und Auswertung, Methoden und Modelle. 4th edition, Springer, Berlin, Heidelberg, New York p. 230 (1974)

    Google Scholar 

  53. Salter, R.H.: Common gastroenterological problems: sliding hiatus hernia. Practitioner214, 264 (1975)

    CAS  PubMed  Google Scholar 

  54. Schayer, R.W.: Significance of induced synthesis of histamine in physiology and pathology. Chemotherapia3, 128 (1961)

    Article  CAS  PubMed  Google Scholar 

  55. Seidel, W., Troidl, H., Lorenz, W., Rohde, H., Richter, H., Drews, H., Hamemann, H.: Eine prospektive, kontrollierte Studie zur selektiven Vagotomie beim chronischen Duodenalulkus: Frühergebnisse mit einer standardisierten Operationsauswahl und Operationstechnik. Klin. Wschr.51, 477 (1973)

    Article  Google Scholar 

  56. Smith, A.N.: Distribution and release of histamine in human gastric tissue. Clin. Sci.18, 32 (1959)

    Google Scholar 

  57. Thunberg, R.: Localization of cells containing and forming histamine in the gastric mucosa of the rat. Exp. Cell. Res.47, 108 (1967)

    Article  CAS  PubMed  Google Scholar 

  58. Tobe, T., Tanaka, Ch.: Histamine containing cells in the human gastric mucosa. Histochemical study using microscopic spectrofluorometry. Amer. J. Gastroent.58, 133 (1972)

    CAS  PubMed  Google Scholar 

  59. Thjodleifsson, B., Wormsley, K.G.: Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man. Gut16, 501 (1975)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Troidl, H., Lorenz, W., Barth, H., Rohde, H., Feifel, G., Schmal, A., Goecke, K., Reimann-Huhnd, A., Seidel, W.: Augmentation of pentagastrin stimulated gastric secretion in the Heidenhain pouch dog by amodiaquine: inhibition of histamine methyltransferase in vivo? Agents and Actions3, 157 (1973)

    Article  CAS  PubMed  Google Scholar 

  61. Troidl, H., Lorenz, W., Rohde, H., Häfner, G., Ronzheimer, M., Schmal, A.: Histamine content in human gastric mucosa: Its relation to pentagastrin-stimulated acid secretion and to selective gastric vagotomy. Agents and Actions5, 427 (1976a)

    Article  Google Scholar 

  62. Troidl, H., Rohde, H., Lorenz, W.: Histamine concentrations in gastric mucosa of duodenal ulcer patients before and one year after selective gastric vagotomy. Brit. J. Surg.63, 155 (1976)

    CAS  PubMed  Google Scholar 

  63. Troidl, H., Lorenz, W., Rohde, H., Fischer, M., Hamelmann, H.: Was ist gesichert in der Behandlung der Ulcuskrankheit durch Vagotomie? Internist (Berl.)16, 575 (1975)

    CAS  PubMed  Google Scholar 

  64. Vance, J.W., Bragg, S.C.: Insulin release in response to microvasoactive substances. Diabetes18, Suppl.1, 326 (1969)

    Google Scholar 

  65. Walpole, St.H., Varco, R.L., Code, C.F., Wangensteen, O.H.: Production of gastric and duodenal ulcers in the cat by intramuscular implantation of histamine. Proc. Soc. exp. Biol. Med.44, 619 (1940)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Surgery Clinic and Division of Experimental Surgery and Pathological Biochemistry of the University of Marburg, Marburg (Lahn)

    H. Troidl, W. Lorenz, H. Rohde, G. Häfner & M. Ronzheimer

  2. Chirurgische Univ.-Klinik, RObert-Koch-Str. 8, D-3550, Marburg a.d. Lahn, Federal Republic of Germany

    H. Troidl

Authors
  1. H. Troidl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Rohde
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Häfner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Ronzheimer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the Deutsche Forschungsgemeinschaft (Lo 199/5)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Troidl, H., Lorenz, W., Rohde, H. et al. Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases. Klin Wochenschr 54, 947–956 (1976). https://doi.org/10.1007/BF01469008

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01469008

Schlüsselwörter

Key words

Search

Navigation