Skip to main content
SpringerLink
Log in

Morbus Dupuytren/Morbus Ledderhose

  • Chapter
Radiotherapy for Non-Malignant Disorders

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The digitopalmar contracture named after Guillaume Dupuytren (1832, 1834) [36, 37] and the corresponding digito-plantar contracture named after Georg Ledderhose (1897) [91] are fibrous, proliferative hyperplastic disorders of pre-existing connective tissue structures of the fascia of the fingers and palm or the toes and sole, respectively. However, in Morbus Dupuytren (MD) and Morbus Ledderhose (ML), the digitopalmar and digitoplantar changes are not just singular afflictions, but part of a systemic connective tissue disorder [41], which is confirmed by subtle biochemical changes and obvious ectopic fibrous deposits, which are located, for example, above the dorsal proximal interphalangeal joints (= knuckle pads), on the auricular helix, the hand wrist, the elbow and inside the penis (= Morbus Peyronie). These tissue changes are histologically identical, but all efforts to identify a single cause of this generalized disorder have failed, and numerous hypotheses about the disease onset and progression have been published, but a simple and straightforward explana tion is still missing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adamietz B, Sauer R (2000) Radiotherapy is effective in early stage Dupuytren’s contracture (ESDC). Int J Radiât Oncol Biol Phys 48 (suppl):243 (abstract)

    Article  Google Scholar 

  2. Adamietz B, Keilholz L, Grünert J, Sauer R (2001) Radiotherapy in early stage Dupuytren’s contracture. Strahlenther Onkol 177:604–610

    Article  PubMed  CAS  Google Scholar 

  3. Allen PW (1977) The fibromatoses: a clinicpathologic classification based on 140 cases. Am J Surg Pathol 1:255–270

    Article  PubMed  CAS  Google Scholar 

  4. Allen RA, Woolner LB, Ghormley RK (1955) Soft tissue tumors of the sole with special reference to plantar fibromatosis. J Bone Joint Surg 37A: 14–28

    Google Scholar 

  5. Allieu Y (1988) La “paume ouverte” dans le traitement de maladie de Dupuytren. Technique et indications. Rev Chir Orthop 74 (Suppl 2):46–49

    Google Scholar 

  6. Alman BA, Naber SP, Terek RM, Jiranek WA, Goldber MJ, Wolfe H (1995) Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures. J Orthop Res 13:67–77

    Article  PubMed  CAS  Google Scholar 

  7. Aluisio FV, Mair SD, Hall RL (1996) Plantar fibromatosis: treatment of primary and recurrent lesions and factors associated with recurrence. Foot & Ankle Int 17:672–678

    CAS  Google Scholar 

  8. Attali P, Ink O, Pelletier G, Vernier C, Jean F, Moulton L, Etienne J-P (1987) Dupuytren’s contracture, alcohol consumption and chronic liver disease. Arch Int Med 147:1065–1067

    Article  CAS  Google Scholar 

  9. Aviles E, Arlene M, Miller T (1971) Plantar fibromatosis. Surgery 69:117–120

    PubMed  CAS  Google Scholar 

  10. Badalamente MA, Samson SP, Hurst C, Down A, Miyasaka K, Brook S (2000) The role of transforming growth factor beta in Dupuytren’s disease. J Hand Surg 21A:210–215

    Google Scholar 

  11. Badalamente MA, Hurst C (2000) Enzyme injection as non-surgical treatment of Dupuytren’s disease. J Hand Surg 25A:629–636

    Google Scholar 

  12. Baird_KS, Crossan JF, Ralston SH (1993) Abnormal growth factor and cytokine expression in Dupuytren’s contracture. J Clin Pathol 46:425–428

    Article  PubMed  CAS  Google Scholar 

  13. Benson LS, Williams CS, Kable M (1998) Dupuytren’s contracture. J Am Acad Orthop Surg 6:24–35

    PubMed  CAS  Google Scholar 

  14. Berndt A, Kosmehl H, Katenkamp D, Tauchmann V (1994) Appearance of the myo-fibroblastic phenotype in Dupuytren’s disease is associated with a fibronectin, laminin, collagen type I and tenascin extracellular matrix. Pathobiology 62:55–58

    Article  PubMed  CAS  Google Scholar 

  15. Blume PA, Courtright DJ, Nierni WJ, Gorecki G (1997) Fibrosarcoma of the foot: a case presentation and review of the literature. J Foot Ankle Surg 36:54–54

    Google Scholar 

  16. Bower M, Nelson M, Gozzard BG (1990) Dupuytren’s contracture in patients infected with HIV. Br Med J 300:164–165

    Article  CAS  Google Scholar 

  17. Brenner P, Mailänder P, Berger A (1994) Epidemiology of Dupuytren’s disease. In: Berger A, Delbrück A, Brenner P, Hinzmann R (eds) Dupuytren’s disease-pathobio-chemistry and clinical management. Springer, Berlin, Heidelberg, pp 244–254

    Google Scholar 

  18. Brenner P, Sachse C, Reichert B, Berger A (1996) Expression von diversen monoklonalen Antikörpern im Knoten-und Strangstadium des Morbus Dupuytren. Handchir Mikrochir Plast Chir 28:322–327

    PubMed  CAS  Google Scholar 

  19. Brenner P, Krause-Bergmann A, Ha Van V (2001) Die Dupuytren’sche Kontraktur in Norddeutschland-Epidemiologische Erfassungsstudie an Hand von 500 Fällen. Unfallchirurg 104:303–311

    Article  PubMed  CAS  Google Scholar 

  20. Brenner P, Rayan GM (2003) Dupuytren’s disease. A concept of surgical treatment. ISBN 3-211-83656-X, Springer, Wien New York, pp 80–81

    Google Scholar 

  21. Brotherston TM, Balakrishanan C, Milner RH, Brown HG (1994) Long-term follow-up of dermatofasciectomy for Dupuytren’s contracture. Br J Plast Surg 47:440–447

    Article  PubMed  CAS  Google Scholar 

  22. Buck-Gramcko D, Hoffmann R, Neumann R (1992) Dupuytrensche Erkrankung. In: Buck-Gramcko D, Nigst H (eds) Die handchirurgische Sprechstunde. Hippokrates, Stuttgart, pp 75–82

    Google Scholar 

  23. Burch PRJ (1966) Dupuytren’s contracture: an auto-immune disease? J Bone Joint Surg 48B:312–319

    Google Scholar 

  24. Bürge AG, Hoy G, Regan P, Milne R (1997) Smoking, alcohol and the risk of Dupuytren’s contracture. J Bone Joint 79B:206–210

    Article  Google Scholar 

  25. Caroli A, Zanasi S, Marcuzzi A, Guerra D, Cristiani G, Ronchetti IP (1991) Epidemiological and structural findings supporting the fibromatous origin of dorsal knuckle pads. J Hand Surg 16B:258–262

    Google Scholar 

  26. Cavolo DJ, Sherwood GF (1982) Dupuytren’s disease of the plantar fascia. J Foot Surg 21:12–15

    PubMed  CAS  Google Scholar 

  27. Classen DA, Hurst LN (1992) Plantar fibromatosis and bilateral flexion contractures: a review of the literature. Ann Plast Surg 28:475–478

    Article  PubMed  CAS  Google Scholar 

  28. Conway H (1954) Dupuytren’s contracture. Am J Surg 87:101–119

    Article  PubMed  CAS  Google Scholar 

  29. Cooper AP (1824) Dislocation form contraction of the tendon. In: Cooper A (ed) A treatise on dislocations and fractures of the joints (4th edn). Messr Longman, Hurst, Rees, Orme, Brown, and Green, London, pp 486–488

    Google Scholar 

  30. Crocker I (1999) Radiation therapy to prevent coronary artery restenosis. Sem Rad Oncol 9:134–143

    Article  CAS  Google Scholar 

  31. Dal Cin P, De Smet L, Sciot R, Van Damme B, Han de Berge H (1999) Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren’s disease. Cancer Genet Ytogen 108:137–140

    Article  Google Scholar 

  32. De Maglio A, Timo R, Feliziani G (1996) Récidive ed estensioni nel morbo Dupuytren trattato con aponeur-ectomia selettiva. Revisioni clinica di 124 casi. Chir Organi Mov 86:43–48

    Google Scholar 

  33. Dominguez-Malagon HR, Alfeiran-Ruiz A, Chavarria-Xicotencatl P, Duran-Hernandez MS (1992) Clinical and cellular effects of colchicines in fibromatosis. Cancer 69:2478–2483

    Article  PubMed  CAS  Google Scholar 

  34. Donato RR, Morrison WA (1996) Dupuytren’s disease in the feet causing flexion contractures in the toes. J Hand Surg 21B:364–366

    Google Scholar 

  35. Dufourmentel C, Beres J (1998) Radiodermatitis of the hand. In: Tubiana R (ed) The hand, vol III. WB Saunders, Philadelphia, London Toronto, pp 849–856

    Google Scholar 

  36. Dupuytren G (1832) Leçons orales de clinique chirurgicale faites a THotel-Dieu de Paris. Bailliere Libraire Paris, Londres pp 1–24

    Google Scholar 

  37. Dupuytren G (1834) Permanent retraction of the fingers, produced by an affection of the palmar fascia. Lancet 2:222–225

    Google Scholar 

  38. Dürr HR, Krödel A, Trouillier H, Lienemann A, Refior HJ (1989) Fibromatosis of the plantar fascia: Diagnosis and indications for surgical treatment. Foot Ankle Int 20:13–17

    Google Scholar 

  39. Early PF (1962) Population studies in Dupuytren’s contracture. J Bone Joint Surg 44B:602–613

    Google Scholar 

  40. Elliot D (1988) The early history of contracture of the palmar fascia. J Hand Surg 13B:246–253

    Google Scholar 

  41. Enzinger FM, Weiss SW (1994) Fibromatosis. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors (3rd edn) St Louis, Mosby Year Book, pp 201–229

    Google Scholar 

  42. Falter E, Herndl E, Muhlbauer W (1991) Dupuytren’s contracture. When operate? Conservative preliminary treatment? Fortschr Med 109:223–226

    PubMed  CAS  Google Scholar 

  43. Finck KW (1955) Zur Frage der Dupuytrenschen Fingerkontaktur und ihrer Behandlung mit Radium. Strahlentherapie 97:608–61

    Google Scholar 

  44. Finney R (1955) Dupuytren’s contracture. Brit J Radiol 28:610–613

    PubMed  CAS  Google Scholar 

  45. Flint M (1990) Connective tissue biology. In: McFarlane RM, McGrouther DA, Flint M (eds) Dupuytren’s disease. Biology and treatment (The hand and upper limb series, vol 5). Churchill Livingstone, Edinburgh, pp 13–24

    Google Scholar 

  46. Flint M (1990) The genesis of the palmar lesion. In: McFarlane RM, McGrouther DA, Flint M (eds) Dupuytren’s disease. Biology and treatment (The hand and upper limb series, vol 5). Churchill Livingstone, Edinburgh, pp 136–154

    Google Scholar 

  47. Foucher G, Cornil C, Lenoble E (1992) La technique de la “plaie ouverte” dans la malarie de Dupuytren. Complications postoperatorie et résultats a plus de 5 ans. Chirurgie 118:189–196

    PubMed  CAS  Google Scholar 

  48. Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experimentia 27:549–550

    Article  CAS  Google Scholar 

  49. Geldmacher J (1994) Limited Fasciectomy. In: Berger A, Delbrück A, Brenner P, Hinzmann R (eds) Dupuytren’s disease. Springer, Berlin Heidelberg, pp 257–263

    Google Scholar 

  50. Godette GA, O’Sullivan M, Menelaus MB (1997) Plantar fibromatosis of the heel in children: a report of 14 cases. J Pediatr Orthop 17:16–17

    Article  PubMed  CAS  Google Scholar 

  51. Gonzalez-Martinez R, Marin-Bertolin S, Amlorrortu-Velayos J (1985) Association between keloids and Dupuytren’s disease: case report. Br J Plast Surg 48:47–48

    Article  Google Scholar 

  52. Gösset J (1985) Dupuytren’s disease and the anatomy of the palmodigital aponeurosis. In: Hueston JT, Tubiana R (eds) Dupuytren’s disease. Churchill Livingstone, Edinburgh London Melbourne, pp 13–16

    Google Scholar 

  53. Goyrand G (1834) Nouvelle recherches sur la retraction permanente de doigts. Mem Acad (Paris) 3:489–490

    Google Scholar 

  54. Gudmundsson KG, Arngrimsson R, Arinbjarnarson S, Olafsson, J Jonsson J (1998) T-and B-lymphocyte subsets in patients with Dupuytren’s disease. J Hand Surg 23:724–727

    CAS  Google Scholar 

  55. Haedicke GJ, Sturim HS (1989) Plantar fibromatosis: an isolated disease. Plast Reconstr Surg 83:296–300

    Article  PubMed  CAS  Google Scholar 

  56. Hall PN, Fitzgerald A, Sterne GD, Logan AM (1997) Skin replacement in Dupuytren’s disease. J Hand Surg 22B:193–197

    Google Scholar 

  57. Hankin FM, Eckenrode J, Louis DS (1986) Oestrogen and progesterone hormone receptors in Dupuytren’s disease. J Hand Surg HB:463–464

    Google Scholar 

  58. Herbst M, Regler G (1986) Dupuytrensche Kontraktur. Radiotherapie der Frühstadien. Strahlentherapie 161:143–147

    Google Scholar 

  59. Hesselkamp J, Schulmeyer M, Wiskemann A (1981) Röntgentherapie der Dupuytrenschen Kontraktur im Stadium I. Therapiewoche 31:6337–6338

    Google Scholar 

  60. Hill NA (1985) Dupuytren’s contracture. J Bone Joint Surg 67:1439–1443

    PubMed  CAS  Google Scholar 

  61. Hueston JT (1960) The incidence of Dupuytren’s contracture. Med J Aust 47:999–1002

    Google Scholar 

  62. Hueston JT (1961) Limited fasciectomy for Dupuytren’s contracture. Plast Reconstr Surg 27:569–585

    Article  CAS  Google Scholar 

  63. Hueston JT (1963) The Dupuytren’s diathesis. In: Hueston JT (ed) Dupuytren’s contracture. E & S Livingstone, Edinburgh, pp 51–63

    Google Scholar 

  64. Hueston JT (1963) Dupuytren’s contracture. Williams & Wilkins, Baltimore

    Google Scholar 

  65. Hueston JT (1971) Enzymatic fasciotomy. Hand 3:38–40

    Article  PubMed  CAS  Google Scholar 

  66. Hueston JT (1974) Aetiological questions in Dupuytren’s contracture. In: Hueston JT, Tubiana R (eds) Dupuytren’s disease. Churchill Livingstone, Edinburgh London Melbourne, pp 29–36

    Google Scholar 

  67. Hueston JT (1976) Table top test. Med J Aust 63:189–190

    Google Scholar 

  68. Hueston JT (1984) Current state of treatment of Dupuytren’s disease. Ann Chir Main 3:81–92

    Article  PubMed  CAS  Google Scholar 

  69. Hueston JT: Dupuytren’s contracture and occupation. J Hand Surg [Am] 1987; 12 A:657–658

    Google Scholar 

  70. Hurst LC, Badalamente M (1990) Associated diseases. In: McFarlane RM, McGrouther DA, Flint MH (eds) Dupuytren’s disease. Biology and treatment. Churchill Livingstone, Edinburgh London Melbourne, pp 253–260

    Google Scholar 

  71. Hurst LC (1996) Dupuytren’s fasciectomy. Zig-zag plasty technique. In: Blair WF, Steyers CM (eds) Techniques in hand surgery. Williams & Wilkins, Baltimore Philadelphia London, pp 519–529

    Google Scholar 

  72. Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K (1996) Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol 106:729–733

    Article  PubMed  CAS  Google Scholar 

  73. James J, Tubiana R (1952) La malarie de Dupuytren. Rev Chir Orthop 38:352–406

    PubMed  CAS  Google Scholar 

  74. Jansen JTM, Broerse JJ, Zoetelief J, Klein C, Seegenschmiedt MH (2005) Estimation of the radiotherapy of benign diseases from shoulder to heel. Radiother Oncol 76:270–277

    Article  PubMed  Google Scholar 

  75. Johnston RE, Collis S, Peckham NH, Rothstein AR (1992) Plantar fibromatosis: literature review and unique case report. J Foot Surg 31:400–406

    PubMed  CAS  Google Scholar 

  76. Jordan GH (1998) Surgery for Peyronie’s disease. In: Libertino JA (ed) Reconstructive urologie surgery. Mosby, St. Louis Baltimore Carlsbad, pp 539–551

    Google Scholar 

  77. Joyce DA (1987) Oxygen radicals in disease. Adverse Drug Res Bull 127:476–479

    Article  Google Scholar 

  78. Keilholz L, Seegenschmiedt MH, Born AD, Sauer R (1997) Radiotherapy in the early stages of Dupuytren’s disease: indication, technique, long-term results. Strahlenther Onkol 173:27–35

    Article  PubMed  CAS  Google Scholar 

  79. Keilholz L, Seegenschmiedt MH, Sauer R (1996) Radiotherapy for prevention of disease progression in early-stage Dupuytren’s contracture: initial and long-term results. Int J Radiât Oncol Biol Phys 36:891–897

    Article  PubMed  CAS  Google Scholar 

  80. Ketchum LD, Hixsen FP (1987) Dermatofasciectomy and full-thickness grafts in the treatment of Dupuytren’s contracture. J Hand Surg 12A:659–663

    Google Scholar 

  81. Kischer CW, Thies AC, Chvapil M (1982) Perivascular myofibroblasts and microvascular occlusion in hyper-trophic scars and keloids. Hum Pathol 13:819–824

    Article  PubMed  CAS  Google Scholar 

  82. Kischer CW, Speer DW (1986) Microvascular changes in Dupuytren’s contracture. J Hand Surg 9A:58–62

    Google Scholar 

  83. Köhler AH (1984) Die Strahlentherapie der Dupuytrenschen Kontraktur. Radiobiol Radiother 25:851–853

    Google Scholar 

  84. Lamb D (1981) Dupuytren’s disease. In: Lamb DW, Kuczynski K (eds) The practice of hand surgery. Blackwell, Oxford London, pp 635–648

    Google Scholar 

  85. Landers PA, Yu GV, White JM, Farrer AK (1993) Recurrent plantar fibromatosis. J Foot Ankle Surg 32:85–93

    PubMed  CAS  Google Scholar 

  86. Lappi DA, Martineau D, Maher PA et al (1992) Basic fibroblast growth factor in cells deprived from Dupuytren’s contracture: synthesis, presence, and implication for treatment of the disease. J Hand Surg 17A:324–332

    Google Scholar 

  87. Latha MS, Vijayammal PL, Krupp PA (1991) Changes in the glycosaminoglycans and glycoproteins in the tissue in rat exposed to cigarette smoking. Artherosclerosis 31:49–54

    Article  Google Scholar 

  88. Lauf E, Freedman BM, Steinberg JS (1998) Autogenous free dermal fat grafts in the surgical approach to plantar fibromatosis. J Foot Ankle Surg 37:227–234

    Article  PubMed  CAS  Google Scholar 

  89. Leclercq C, Tubiana R (1986) Resultat a long terme des aponevrectomies pur maladie de Dupuytren. Chirurgie, 112:194–197

    PubMed  CAS  Google Scholar 

  90. Leclercq C, Hurst LC, Badalamente MA (2000) Non-surgical treatment. In: Tubiana R, Leclercq C, Hurst LC, Badalamente MA, Mackin EJ (eds) Dupuytren’s disease. Martin Dunitz, London Maiden Winnipeg Sao Paulo, pp 121–131

    Google Scholar 

  91. Ledderhose H (1897) Zur Pathologie der Aponeurose des Fusses und der Hand. Langenbecks Arch Klin Chir 55:694–712

    Google Scholar 

  92. Lee TK, Wapner KL, Hecht PJ (1993) Current concept review: plantar fibromatosis. J Bone Joint Surg 75A:1080–1083

    Google Scholar 

  93. Lermusiaux J-L, Lellouche H, Badois J-F, Kuntz D (1997) How should Dupuytren’sn disease be managed in 1997? Rev Rheum (Engl Ed) 64:775–776

    CAS  Google Scholar 

  94. Lexer E (1931) Die gesamte Wiederherstellungschirurgie. 2. Auflage, Barth, Leipzig, pp 837–844

    Google Scholar 

  95. Ling RSM (1963) The genetic factor in Dupuytren’s disease. Bone Joint Surg 45B:709–718

    Google Scholar 

  96. Liss GM, Stock SR (1996) Can Dupuytrenn’s contracture be work-related? Review of evidence. Am J Ind Med 29:521–532

    Article  PubMed  CAS  Google Scholar 

  97. Little MP, Muirhead CR, Haylock RGE, Thomas JM (1999) Relative risks of radiation-associated cancer: comparison of second cancer in therapeutically irradiated populations with the Japanese atomic bomb survivors. Radiât Environ Biophys 38:267–283

    Article  PubMed  CAS  Google Scholar 

  98. Lubahn JD, Lister GD, Wolfe T (1984) Fasciectomy of Dupuytren’s disease, comparison between the open-palm technique and wound closure. J Hand Surg 9A:53–58

    CAS  Google Scholar 

  99. Lubahn JD (1999) Open-palm technique and soft-tissue coverage in Dupuytren’s disease. Hand Clinics 15:127–136

    PubMed  CAS  Google Scholar 

  100. Luck JV (1959) Dupuytren’s contracture: a new concept of pathogenesis correlated with surgical management. J Bone Joint Surg 41A:635–664

    Google Scholar 

  101. Lukacs S, Braun Falco O, Goldschmidt H (1978) Radiotherapy of benign dermatoses: indications, practice, and results. J Dermatol Surg Oncol 4:620–625

    PubMed  CAS  Google Scholar 

  102. McFarlane RM (1988) Dupuytren’s contracture. In: Green DP (ed) Operative hand surgery, vol 1, Churchill Livingstone, New York Edinburgh London, pp 553–559

    Google Scholar 

  103. McFarlane RM, McGrouther DA, Flint MH (1990) Dupuytren’s disease. Biology and treatment. The hand and upper limb series, vol 5. Churchill Livingstone, Edinburgh London New York

    Google Scholar 

  104. McFarlane RM (1997) Dupuytren’s disease. J Hand Ther 10:8–13

    PubMed  CAS  Google Scholar 

  105. McGrouther DA (1982) The microanatomy of Dupuytren’s contracture. Hand 13:215–236

    Google Scholar 

  106. McGrouther DA (1999) Dupuytren’s contracture. In: Green DP, Hotchkiss RN, Pederson WC (eds) Green’s operative hand surgery. Churchill Livingstone, New York Edinburgh London, pp 563–591

    Google Scholar 

  107. Menzel EJ, Piza H, Zielinski C, Ender AT, Steffen C, Millesi H (1979) Collagen types and anticollagen-antibodies in Dupuytren’s disease. Hand 11:243–248

    Article  PubMed  CAS  Google Scholar 

  108. Messina A, Messina J (1991) The TEC (continuous extension technique) for severe Dupuytren’s contracture of the fingers. Ann Hand Surg 10:247–250

    CAS  Google Scholar 

  109. Micke O, Seegenschmiedt MH, and the German Working Group on Radiotherapy of Benign Diseases (2002) Consensus guidelines for radiation therapy of benign diseases: a multicenter approach in Germany. Int J Radiat Oncol Biol Phys 52:496–513

    PubMed  Google Scholar 

  110. Mikkelsen OA (1972) The prevalence of Dupuytren’s disease in Norway. A study in a retrospective population sample of the municipality of Haugesund: Acta Chir Scand 138:695–700

    PubMed  CAS  Google Scholar 

  111. Mikkelsen OA (1990) Epidemiology of a Norwegian population. In: McFarlane RM, McGrouther DA, Flint MH (eds) Dupuytren’ disease. Churchill Livingstone, Edinburgh Melbourne New York, pp 191–200

    Google Scholar 

  112. Millesi H (1965) Zur Pathogenese und Therapie der Dupuytrenschen Kontraktur (eine Studie an Hand von mehr als 500 Fällen). Ergebnisse der Orthopädie 47:51–101

    Google Scholar 

  113. Millesi H (1981) Dupuytren-Kontraktur. In: Nigst H, Buck-Gramcko D, Millesi H (eds) Handchirurgie, Band I. Allgemeines, Wahloperationen. Thieme, Stuttgart New York pp 15.01–15.57

    Google Scholar 

  114. Moermans JP (1991) Segmental aponeurectomy in Dupuytren’s disease. J Hand Surg 16B:243–254

    Google Scholar 

  115. Moermans JP (1996) Long-term results after segmental aponeurectomy for Dupuytren’s disease. J Hand Surg 21B:797–800

    Google Scholar 

  116. Mumenthaler M, Schliack H (1982) Läsionen peripherer Nerven. Thieme, Stuttgart

    Google Scholar 

  117. Murell GAC, Murell TGC, Pilowsky EA (1987) A hypothesis for the resolution of Dupuytren’s contracture with allopurinol. Speculations in Science and Technology 10:107–11

    Google Scholar 

  118. Murell GAC, Francis MJO, Bromley L (1987) Free radicals and Dupuytren’s contracture. Br Med J 295:1373–1375

    Article  Google Scholar 

  119. Murrell GAC, Francis MJO, Howlett CR (1989) Dupuytren’s contracture, fine structure in relation to aetiology. J Bone Joint Surg 71B:367–372

    Google Scholar 

  120. Murrell GAC, Francis MJO; Bromley L (1990) Modulation of fibroblast proliferation by oxygen free radiacals. Biochem J 165:659–665

    Google Scholar 

  121. Murreil GAC (1992) An insight into Dupuytren’s contracture. Ann Roy Coll Surg (Engl) 74:156–161

    Google Scholar 

  122. Murreil GAC, Francis MJO (1994) Oxygen free radiacals and Dupuytren’s disease. In: Berger A, Delbrück A, Brenner P, Hinzmann R (eds) Dupuytren’s disease. Pathobiochemistry and clinical management. Springer, Berlin Heidelberg New York, pp 227–234

    Google Scholar 

  123. Mutsaers SE, Bishop JE, McGroutherG, Laurent GJ (1997) Mechanisms of tissue repair: from wound healing to fibrosis. Int J Biochem Cell Biol 29:5–17

    Article  PubMed  CAS  Google Scholar 

  124. Noble J, Arafa M, Royle SG, McGeorge G, Crank S (1992) The association between alcohol, hepatic pathology and Dupuytren’s disease. J Hand Surg 17B:71–74

    Google Scholar 

  125. Norotte G, Apoil A, Travers V (1988) Resultat a plus de dix ans de la maladie de Dupuytren: A propos de cinquante-huit observation. Ann Chir Main 7:277–281

    Article  PubMed  CAS  Google Scholar 

  126. Nyberg LM, Bias WB, Hochberg MC, Walsh PC (1982) Identification of an inherited form of Peyronie’s disease with autosomal dominant inheritance and association with Dupuytren’s contracture and histocompatibility B7 cross-reacting antigens. J Urol 128:48–52

    PubMed  Google Scholar 

  127. Pal B, Griffiths ID, Anderson J, Dich WC (1987) Association of limited joint mobility with Dupuytren’s contracture in diabetes mellitus. J Rheumatol 14:582–585

    PubMed  CAS  Google Scholar 

  128. Pentland AP, Anderson TF (1985) Plantar fibromatosis responds to intralesional steroids. J Am Acad Dermatl 12:212–214

    Article  CAS  Google Scholar 

  129. Pereira RS, Black CM, Turner SM, Spencer JD (1986) Antibodies to collagen types I-IV in Dupuytren’s contracture. J Hand Surg 11B:58–60

    Google Scholar 

  130. Pickren JW, Smith AG, Stevenson TW, Stout AP (1951) Fibromatosis of the plantar fascia. Cancer 4:846–856

    Article  PubMed  CAS  Google Scholar 

  131. Platter F (1614) Observationum, in hominibus affectibus plerisque, corpori et animo, functionum laesione, dolore, aliave molestia et vitio incommodantibus, libri très. Liber primus. L. König, Basel, pp 137–145

    Google Scholar 

  132. Rabinowitz JL, Ostermann JR, Bora FW, Steffer J (1983) Lipid composition and de novo lipid biosynthesis of human palmar fat in Dupuytren’s disease. Lipids 18:371–373

    Article  PubMed  CAS  Google Scholar 

  133. Rafter D, Kenny R, Gilmore M, Walsh CH (1980) Dupuytren’s contracture-a survey of a hospital population. Ir Med J 73:227–228

    PubMed  CAS  Google Scholar 

  134. Rao GS, Luthra PK (1988) Dupuytren’s disease of the foot in children: a report of three cases. J Plast Surg 28:475–478

    Google Scholar 

  135. Rayan GM, Parizi M, Tomasek JJ (1996) Pharmacological regulation of Dupuytren’s fibroblast contraction in vitro. J Hand Surg Am 21:1065–1070

    Article  PubMed  CAS  Google Scholar 

  136. Rodemann HP, Bamberg M (1995) Cellular basis of radiation induced fibrosis. Radiother Oncol 35:83–90

    Article  PubMed  CAS  Google Scholar 

  137. Rodemann HP, Peterson HP, Schwenke K, von Wangenheim KH (1991) Terminal differentiation of human skin fibroblasts is induced by radiation. Scand Microsc 5:1135–1143

    CAS  Google Scholar 

  138. Rosenbloom AL, Silverstein JH (1996) Connective tissue and joint disease in diabetes mellitus. Endocrin Met North Amer 25:473–483

    Article  CAS  Google Scholar 

  139. Rubin P, Constine LS, Fajardo LF, Phillips TL, Wasserman TH (1996) Overview: late effects of normal tissue (LENT) scoring system. Int J Radiât Oncol Biol Phys 31:1041–1042

    Article  Google Scholar 

  140. Rubin P, Soni A, Williams JP (1999) The molecular and cellular biologic basis for radiation treatment of benign proliferative diseases. Sem Rad Oncol 9:203–214

    Article  CAS  Google Scholar 

  141. Rudolph R, Van de Berg J (1991) The myofibroblast in Dupuytren’s contracture. Hand Clin 7:683–692

    PubMed  CAS  Google Scholar 

  142. Sammarco GJ, Mangone PG (2000) Classification and treatment of plantar fibromatosis. J Foot Ankle Int 21:563–569

    CAS  Google Scholar 

  143. Seegenschmiedt MH, Olschewski T, Guntrum F (2001) Optimierung der Radiotherapie beim Morbus Dupuytren: erste Ergebnisse einer kontrollierten Studie. Strahlenther Onkol 177:74–81

    Article  PubMed  CAS  Google Scholar 

  144. Seegenschmiedt MH, Attassi M (2003) Strahlentherapie beim Morbus Ledderhose-Indikation und Ergebnisse. Strahlenther Onkol 179(12):847–853

    Article  PubMed  Google Scholar 

  145. Sennwald GR (1990) Fasciectomy for treatment of Dupuytren’s disease and early complications. J Hand Surg 15A:755–761

    Google Scholar 

  146. Sinha A (1997) Dupuytren’s disease may extend beyond the wrist crease in continuity. J Bone Joint Surg 79B:211–212

    Article  Google Scholar 

  147. Skoog T (1948) Dupuytren’s contraction with special reference to aetiology and improved surgical treatment, its occurrence in epileptics. Acta Chir Scand 96 (Suppl): pl39

    Google Scholar 

  148. Smitt MC, Donaldson SS (1999) Radiation therapy for benign disease of the orbit. Sem Rad Oncol 9:179–189

    Article  CAS  Google Scholar 

  149. Snyder M (1980) Dupuytren’s contracture and plantar fibromatosis: is there more than a causal relationship? J Am Podiatry Assoc 70:410–415

    PubMed  CAS  Google Scholar 

  150. Strickland JW, Idler RS, Creighton JC (1990) Dupuytren’s disease. Indiana Med 83:408–409

    PubMed  CAS  Google Scholar 

  151. Stirpe F, Gasperi-Campani A, Barbieri L, Falasca A, Abbondanza A, Stevens WA (1983) Ribosome-inactivating proteins from the seed of Saponaria officinalis L. (soapwort) of Agrostemma githoga L. (corn cockle) and of Asparagus officinalis L. (asparagus), and from the latex of Hura crepitans L. (sandbox tree). Biochem J 216:617–625

    PubMed  CAS  Google Scholar 

  152. Suit H, Spiro I (1999) Radiation treatment of benign mesenchymal disease. Sem Rad Oncol 9:171–178

    Article  CAS  Google Scholar 

  153. Terek RM, Jiranek WA, Goldberg MJ, Wolfe HJ, Alman BA (1995) The expression of platelet-derived growth-factor gene in Dupuytren contracture. J Bone Joint Surg 77A:l–9

    Google Scholar 

  154. Tomasek JJ, Schultz RJ, Haaksma CJ (1987) Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease. J Bone Joint Surg 69A:1400–1407

    Google Scholar 

  155. Tomasek J, Rayan GM (1995) Correlation of alpha-smooth muscle actin expression and contraction in Duputren’s disease fibroblasts. J Hand Surg Am 20:450–455

    Article  PubMed  CAS  Google Scholar 

  156. Tonkin MA, Burke FD, Varian JPW (1984) Dupuytren’s contracture: a comparative study of fasciectomy and dermatofasciectomy in 100 patients. J Hand Surg 1984; 9B:156–162

    Google Scholar 

  157. Tripuranemi P, Giap H, Jani S (1999) Endovascular brachytherapy for peripheral vascular disease. Sem Rad Oncol 9:190–202

    Article  Google Scholar 

  158. Tubiana R, Micron J (1961) Evaluation chiffrée de la deformation dans la maladie de Dupuytren. Mem Acad Chir 87:887–888

    Google Scholar 

  159. Tubiana R, Michon J, Thomine JM (1966) Evaluation chiffrée des deformations dans la maladie de Dupuy tren. In: Maladie du Dupuytren (monographies du G.E.M.) Paris, Expansion Scientifique Française, Paris, pp 86

    Google Scholar 

  160. Tubiana R, Leclercq C (1986) Les recives de la malarie de Dupuytren. Tubiana R, Hueston JT (eds) La maladie de Dupuytren. Expansion Scientifique Française, Paris, pp 111–114

    Google Scholar 

  161. Tubiana R (1999) Dupuytren’s disease of the radial side of the hand. Hand Clinics 15:149–159

    PubMed  CAS  Google Scholar 

  162. Ushijima M, Tsuneyoshi M, Enjoji M (1984) Dupuytren type fibromatoses. A clinico-pathologic study of 62 cases. Acta Pathol Jpn 34:991–1001

    PubMed  CAS  Google Scholar 

  163. Viljanto JA (1973) Dupuytren’s contracture: A review. Semin Arthritis Rheum 3:155–176

    Article  Google Scholar 

  164. Vogt HJ, Hochschau L (1980) Behandlung der Dupuytrenschen Kontraktur. Munch Med Wschr 122:125–130

    CAS  Google Scholar 

  165. Wapner KL, Ververell PA, Moore JH et al (1995) Plantar fibromatosis: a review of primary and recurrent surgical treatment. Foot Ankle Int 16:548–551

    PubMed  CAS  Google Scholar 

  166. Wasserburger K (1956) Therapie der Dupuytrenschen Kontraktur. Strahlenther 100:546–560

    CAS  Google Scholar 

  167. Weinzierl G, Flügel M, Geldmacher J (1993) Fehlen der Effektivität der alternativ nicht-chirurgischen Behandlungsverfahren beim Morbus Dupuytren. Chirurg 64:492–494

    PubMed  CAS  Google Scholar 

  168. Wheeler ES, Meals S (1981) Dupuytren’s diathesis: abroad spectrum disease. Plast Reconstr Surg 771–783

    Google Scholar 

  169. White JM, Heckler FR (1990) Oxygen free radicals and wound healing. Clin Plastic Surg 17:473–484

    CAS  Google Scholar 

  170. Woodruff MJ, Waldram MA (1998) A clinical grading system for Dupuytren’s contracture. J Hand Surg 13:67–72

    Google Scholar 

  171. Woolridge WE (1988) Four related fibrosing diseases. When you find one, look for another. Postgrad Med 84:269–271

    Google Scholar 

  172. Yost J, Winter T, Fett H (1955) Dupuytrens contracture. A statistical study. Am J Surg 90:568–571

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Radiation Oncology and Therapeutic Radiology, Alfried Krupp Hospital, Alfried Krupp Straße 21, 45117, Essen, Germany

    Michael Heinrich Seegenschmiedt MD (Professor)

Authors
  1. Michael Heinrich Seegenschmiedt MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology and Therapeutic Radiology, Alfried-Krupp-Hospital, Alfried-Krupp-Strasse 21, Postfach 10 22 43, 45117, Essen, Germany

    Michael Heinrich Seegenschmiedt MD (Professor) (Professor)

  2. Strahlenklinik Klinikum Duisburg, Zu den Rehwiesen 9, 47055, Duisburg, Germany

    Hans-Bruno Makoski MD (Professor) (Professor)

  3. Department of Radiation Biology, St. Bartolomew’s Medical College, Charterhouse Square, London, EC1M 6BQ, UK

    Klaus-Rüdiger Trott MD (Professor) (Professor)

  4. Hylda Cohn/American Cancer Society, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

  5. College of Medicine, Drexel University, Broad & Vine Sts., Mail Stop 200, Philadelphia, PA, 19102-1192, USA

    Luther W. Brady MD (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor) (Professor of Clinical Oncology, and Professor, Department of Radiation Oncology Distinguished University Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Seegenschmiedt, M.H. (2008). Morbus Dupuytren/Morbus Ledderhose. In: Seegenschmiedt, M.H., Makoski, HB., Trott, KR., Brady, L.W. (eds) Radiotherapy for Non-Malignant Disorders. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68943-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-68943-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-62550-6

  • Online ISBN: 978-3-540-68943-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation