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Brain Renin-Angiotensin System: A Novel Therapeutic Target for Psychostimulant and Alcohol Related Disorders?

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Psychiatry and Neuroscience Update

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Abstract

The renin angiotensin system (RAS) is involved not only in the regulation of blood pressure and fluid homeostasis, but also in the modulation of multiple additional functions in the brain. In this sense, it was found to be involved in many neuroadaptive responses induced by drugs such as cocaine, amphetamines, alcohol, as well as others.

It is known that the dopaminergic neurotransmission in the nucleus accumbens and caudate-putamen plays a critical role in the rewarding effects of psychostimulant drugs and alcohol. The main and more studied actions of RAS are mediated by the neuropeptide Angiotensin II (Ang II) that belongs to the group of peptides known to stimulate dopamine release.

There is growing evidence showing the key role of RAS in the development of neuroadaptive changes related to behavioral sensitization induced by natural reinforcers and drugs known to be abused. Recently, we found evidence involving the AT1 receptors in the neuroadaptive changes induced by amphetamine. Moreover, others found evidence that Ang II AT1 receptors are strongly involved in ethanol intake in rodents.

Our goal is to present and discuss the evidence supporting an important role of brain RAS in neuroadaptive responses induced by two of the most abused drugs: amphetamine and alcohol, proposing this system as a potential therapeutic target in the treatment of disorders related to these drugs of choice for abuse.

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Authors and Affiliations

  1. Departamento de Farmacología, Facultad de Ciencias Químicas, Instituto de Farmacología Experimental Córdoba (IFEC-CONICET), Universidad Nacional de Córdoba (UNC), Haya de la Torre S/N, Ciudad Universitaria, Córdoba, Argentina

    M. Constanza Paz Ph.D., Natalia A. Marchese Ph.D. & Claudia Bregonzio Ph.D.

  2. Laboratorio de Neurofarmacología, Facultad de Ciencias Químicas, Instituto de Investigaciones Biológicas y Tecnológicas (IIBYT), National Council of Scientific and Technical Research (CONICET), Universidad Nacional de Córdoba, Universidad Católica de Córdoba, Córdoba, Argentina

    Gustavo C. Baiardi Ph.D.

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  1. M. Constanza Paz Ph.D.
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  3. Claudia Bregonzio Ph.D.
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Correspondence to M. Constanza Paz Ph.D. .

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  1. Guaymallen Mendoza, Argentina

    Pascual Ángel Gargiulo

  2. Member of the Council of the Institute of Neurobiology (Buenos Aires); Member of the Board of Certification, National Academy of Medicine (Argentina), Psychiatrist by University Complutense of Madrid and University of Buenos Aires; Former Director of National Institute of Mental Health (Argentina), Cuyo, Buenos Aires, Argentina

    Humberto Luis Mesones Arroyo

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Paz, M.C., Marchese, N.A., Bregonzio, C., Baiardi, G.C. (2015). Brain Renin-Angiotensin System: A Novel Therapeutic Target for Psychostimulant and Alcohol Related Disorders?. In: Gargiulo, P., Arroyo, H. (eds) Psychiatry and Neuroscience Update. Springer, Cham. https://doi.org/10.1007/978-3-319-17103-6_7

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