Abstract
The intramural blood vessels and fluid-filled interstitial space form a hydraulic continuum enmeshed by myocardial muscle layers and collagen matrix. Coronary circulation was found to be strongly influenced by passive and active properties of the muscle surrounding the coronary microvasculature. Selective remodeling of the extracellular collagen-matrix and partial uncoupling of the intramyocardial structure(s) cause profound functional alterations in the coronary circulation and interstitial compartment fluid-dynamics. Mechanical impediment to coronary inflow resides in the muscle fiberinterstitium-microvessel interface, functioning independently of the generated chamber pressure conditions.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Spaan JAE, Breuls NPW, Laird JD. Diastolic-systolic flow differences are caused by intramyocardial pump action in the anaesthetized dog. Circ Res 1981; 49: 584–593.
Downey JM, Kirk ES. Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res 1975; 36: 753–760.
Arts T, Reneman RS. Interaction between intramyocardial pressure (IMP) and myocardial circulation. J Biomech Eng 1985; 107: 51–56.
Hoffman JIE. The regulation of total regional coronary blood flow. In: Sideman S, Beyar R (eds) Simulation and Control of the Cardiac System, Vol H. Boca Raton: CRC Press, 1985, pp 133–141
Arts T, Reneman RS, Veenstra PC. A model of the mechanics of the left ventricle. Ann Biomed. Eng 1979; 7: 299–318.
Falsetti HL, Mates RE, Grant C, Greene DG, Bunnell JL. Left ventricular wall stress calculated from one-plane cineangiography. Circ Res 1970; 26: 71–83.
Mirsky I. Left ventricular stresses in intact human heart. Biophys J 1969; 9: 189–208.
Rabbany SY, Kresh JY, Noordergraaf A. Intramyocardial pressure: interaction of myocardial fluid pressure and fiber stress. Am J Physiol 1989; 257: H357–H364.
Caulfield JB, Borg TK. The collagen network of the heart. Lab Invest 1979; 40: 364–372.
Kresh JY, Fox M, Brockman SK, Noordergraaf A. Model based analysis of transmural vessel impedance and myocardial circulation dynamics. Am J Physiol (Heart Circ Phys 27) 1990; 258: H262–H276.
Kresh JY, Cobanoglu MA, Brockman SK. The intramyocardial pressure: a parameter of heart contractility. J Heart Transplant 1985; 4: 241–246.
Krams R, van Haelst ACTA, Sipkema P, Westerhof N. Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance? Basic Res Cardiol 1989; 84: 149–159.
Kresh JY, Frasch HF, McVey M, Brockman SK, Noordergraaf A. Mechanical coupling of the myocardium with coronary circulation in the beating and arrested heart. Circulation 1991; 84(4): 11–45.
Kresh JY, McVey M, Frasch HF, Brockman SK. Collagen-matrix dependent modulation of coronary circulation dynamics. Circulation 1992; 86(4): 1–170
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kresh, J.Y. (1993). Intramyocardial Mechanical States: Vessel-Interstitium-Muscle Interface. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_11
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2946-0_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6280-7
Online ISBN: 978-1-4615-2946-0
eBook Packages: Springer Book Archive