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Chemokines and Metastasis

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The Tumor Microenvironment

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Chemokines are a large group of low-molecular-weight cytokines that are known to direct migration of leukocytes in response to inflammation and pathologic stimuli. Although the primary function of chemokines is well recognized as leukocyte attractants, recent evidences indicate that chemokines and their receptors influence tumor development, growth, angiogenesis, invasion, and metastasis. Chemokines activate cells through cell surface seven trans-membrane, G-protein-coupled receptors (GPCR), resulting in cell invasion, motility, and survival. The role played by chemokines and their receptors in tumor pathophysiology is complex as some chemokines favor tumor growth and metastasis, whereas others may enhance anti-tumor immunity. These diverse functions of chemokines establish them as key mediators between the tumor cells and their microenvironment and play a critical role during tumor progression and metastasis. Manipulating chemokine–chemokine receptor network is an emerging novel targeted therapeutic strategy for various malignancies. In this chapter, we will review recent advances in chemokine research with special emphasis on their role in host–tumor interaction during tumor progression, angiogenesis, and metastasis.

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Acknowledgements

This work was supported in part by grants CA72781 (R.K.S.) and Cancer Center Support Grant (P30CA036727) from National Cancer Institute, National Institutes of Health and Nebraska Research Initiative Cancer Glycobiology Program (R.K.S.).

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  1. Department of Pathology and Microbiology, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE, 68198-5900, USA

    Rakesh K. Singh

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  1. Kalyan C. Nannuru
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  2. Seema Singh
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  3. Rakesh K. Singh
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Correspondence to Rakesh K. Singh .

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    Rebecca G. Bagley

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Nannuru, K.C., Singh, S., Singh, R.K. (2010). Chemokines and Metastasis. In: Bagley, R. (eds) The Tumor Microenvironment. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6615-5_27

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