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Regulation of Tumor Angiogenesis by Organ-Specific Cytokines

  • Chapter
Attempts to Understand Metastasis Formation II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 213/2))

Abstract

The outcome of cancer metastasis is dependent on a series of interactions between tumor cells and host factors (Fidler 1990). A crucial step in tumor progression and metastasis is vascularization of the tumor and its immediate surroundings (Folkman 1992). Without the ability to recruit new blood vessels, it is likely that most tumors would not grow beyond 1–2 mm and thus remain localized at the primary site. The induction of neovascularization is mediated by both tumor cells and host cells and the interaction of the two. In this article, we will discuss these interactions in the regulation of the angiogenic phenotype and how organ-derived cytokines modulate the expression of angiogenic factors.

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Authors and Affiliations

  1. Department of Cell Biology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 173, 77030, Houston, TX, USA

    R. K. Singh & I. J. Fidler

Authors
  1. R. K. Singh
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  2. I. J. Fidler
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., PD

  2. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Singh, R.K., Fidler, I.J. (1996). Regulation of Tumor Angiogenesis by Organ-Specific Cytokines. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation II. Current Topics in Microbiology and Immunology, vol 213/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61109-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-61109-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64698-0

  • Online ISBN: 978-3-642-61109-4

  • eBook Packages: Springer Book Archive

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