Abstract
To test the hypothesis that the cytokines interleukin-6 (IL-6) and IL-8 may play regulatory roles in the aberrant neovascularization in chronic inflammatory diseases, we examined their effects in a rat sponge model and compared their actions with those of IL-1 and lumor necrosis factor-α (TNF-α). Daily doses of 3 pmol IL-8, IL-1, TNF-α, but nol IL-6, significantly accelerated the sponge-induced angio-genesis. Although lower doses (0.3 pmol) of these cytokines were inactive, IL-1 acted synergistically with subthreshold daily doses (10 pmol) of substance P (SP) and bradykinin (BK) to produce an intense angiogenic response. In contrast, IL-8 only interacted positively with IL-1, but not TNF-α, SP, or BK. There was no synergism or antagonism between IL-6 and SP. These results demonstrate the discrete interactions between angiogenic factors and cytokines in chronic inflammation and suggest that the sponge model is a good means for the study of such interactions.
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Hu, D.E., Hori, Y. & Fan, T.P.D. Interleukln-8 stimulates angiogenesis in rats. Inflammation 17, 135–143 (1993). https://doi.org/10.1007/BF00916100
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DOI: https://doi.org/10.1007/BF00916100