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Cancer Stem Cells in Solid Tumors, Markers and Therapy

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Stem Cells and Human Diseases

Abstract

Cancer is a multi-factorial disease related with a high number of deaths in the world. There are three cancer models which try to explain the origin and behavior of most known cancers: The stochastic, hierarchical and phenotype plasticity models, which are not exclusive of one an other. However, the most common cancers known until now follow the hierarchical model. In this model only cancer stem cells and some early progenitor cells have the capacity to initiate tumor growth. In this chapter, we focus on the cancers that follow this hierarchical model and the current therapeutic strategies designed to eliminate cancer stem cells in order to improve patient health.

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Acknowledgments

We thank CONACyT for the fellowship to support the Ph.D. student José Luis González-Montoya. Finally, we thank Instituto Nacional de Cancerología for supporting my professional development.

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Authors and Affiliations

  1. Instituto Nacional de Cancerología SS, Av. San Fernando 22, Mexico City, 14080, Mexico

    Ortiz-Sánchez Elizabeth, González-Montoya José Luis, Langley Elizabeth & García-Carrancá Alejandro

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  1. Ortiz-Sánchez Elizabeth
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  2. González-Montoya José Luis
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  3. Langley Elizabeth
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  4. García-Carrancá Alejandro
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Correspondence to Ortiz-Sánchez Elizabeth .

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  1. , Pharmacology and Toxicology, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Rakesh Srivastava

  2. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Sharmila Shankar

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Elizabeth, OS., Luis, GM.J., Elizabeth, L., Alejandro, GC. (2012). Cancer Stem Cells in Solid Tumors, Markers and Therapy. In: Srivastava, R., Shankar, S. (eds) Stem Cells and Human Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2801-1_6

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