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Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

  • Book
  • © 2003

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Editors:
  1. Henry Jay Forman

    1. University of Alabama at Birmingham, Birmingham, USA

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  2. Jon Fukuto

    1. University of California at Los Angeles, Los Angeles, USA

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  3. Martine Torres

    1. Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. Chemical Principles in Reactive Oxygen and Nitrogen Signaling

    1. Redox State and Redox Environment in Biology

      • Freya Q. Schafer, Garry R. Buettner
      Pages 1-14

    2. Sulfur and Selenium Catalysis as Paradigms for Redox Regulations

      • Leopold Flohé
      Pages 15-32

    3. Thiols of Thioredoxin and Glutaredoxin in Redox Signaling

      • Anne Holmgren
      Pages 33-52

    4. Reactivity and Diffusivity of Nitrogen Oxides in Mammalian Biology

      • Jack R. Lancaster Jr.
      Pages 53-79

    5. Bacterial Peroxiredoxins

      • Leslie B Poole
      Pages 80-101

  3. Redox Signaling

    1. The Nox Enzymes and the Regulated Generation of Reactive Oxygen Species

      • Rebecca S. Arnold, J. David Lambeth
      Pages 102-118

    2. NO Synthesis and NOS Regulation

      • Ulrich Forstermann, Huige Li, Petra M. Schwarz, Hartmut Kleinert
      Pages 119-154

    3. S-nitrosothiols in Cell Signaling

      • Joseph Loscalzo
      Pages 155-166

    4. Hydrogen Peroxide as Intracellular Messenger: Identification of Protein Tyrosine Phosphatases and Pten as H2O2 Target

      • Sue Goo Rhee, Seung-Rock Lee, Kap-Seok Yang, Jaeyul Kwon, Sang Won Kang
      Pages 167-179

    5. 4-Hydroxynonenal Signaling

      • Giuseppe Poll, Gabriella Leonarduzzi, Elena Charpotto
      Pages 180-193

    6. Ceramide Signaling under Oxidative Stress

      • Tzipora Goldkorn, Tommer Ravid, Edward A Medina
      Pages 194-222

    7. Map Kinases in Redox Signaling

      • Atsushi Matsuzawa, Hideki Nishitoh, Kohsuke Takeda, Hidenori Ichijo
      Pages 223-236

    8. Activation of Prostaglandin Biosynthesis: Peroxynitrite vs Hydroperoxides

      • Lisa Landino
      Pages 237-255

    9. Phylogenetic Conservation of the Nrf2-Keap1 Signaling System

      • Xue Zhang, Gark Garfinkel, Douglas Ruden
      Pages 256-274

  4. Physiology and Pathophysiology

    1. The NO-cytochrome C Oxidase Signaling Pathway; Mechanisms and Biological Implications

      • Sruti Shiva, Anna-Liisa Levonen, Maria Cecilia Barone, Victor M. Darley-Usmar
      Pages 275-290

    2. The Concept of Compartmentalization in Signaling by Reactive Oxygen Species

      • Victor J. Thannickal, Barryl Fanburg
      Pages 291-310

    3. Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling

      • Cecilia Giulivi, Merry Jo Oursler
      Pages 311-332

    4. Redox Regulation of Gene Expression: Transcriptional Induction of Heme Oxygenase-1

      • Timothy P. Dalton, Lei He, Howard G. Shertzer, Alvaro Puga
      Pages 333-364

    5. Apoptosis Mechanisms Initiated by Oxidative Stress

      • Irene E Kochevar
      Pages 365-378
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About this book

Henry Jay Forman, Jon Fukuto and Martine Torres "Research is to see what everybody else has seen and to think what nobody else has thought. " -- Albert Szent-Gyorgyi Several years ago, one of us put together a book that dealt with various aspects of oxidative stress and introduced the concept of signal transduction by oxidants. Since then, the interest in the mechanisms by which reactive oxygen and nitrogen species (ROS/RNS) can modulate the cell’s response has tremendously grown, paralleling the intense efforts towards identifying new signaling pathways in which phosphorylation/dephosphorylation events take center stage. Evidence is now mounting that production of these species by the cells is required for their function from growth to apoptosis and numerous signaling pathways have been identified where the participation of ROS and RNS is apparent (see Chapters 11-14, 16 and 18). Thus, the field is no more limited to the group of free radical aficionados who have pioneered this area of research but has now gone mainstream. While it is satisfactory for those of us who have been working on this topic for a long time, it has the risk of becoming the “fashionable” motto where those molecules, still mysterious to some, become responsible for everything and anything.

Editors and Affiliations

  • University of Alabama at Birmingham, Birmingham, USA

    Henry Jay Forman

  • University of California at Los Angeles, Los Angeles, USA

    Jon Fukuto

  • Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, USA

    Martine Torres

Bibliographic Information

  • Book Title: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

  • Editors: Henry Jay Forman, Jon Fukuto, Martine Torres

  • DOI: https://doi.org/10.1007/0-306-48412-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2003

  • Hardcover ISBN: 978-1-4020-1117-7Published: 31 March 2003

  • Softcover ISBN: 978-90-481-6216-1Published: 30 July 2011

  • eBook ISBN: 978-0-306-48412-4Published: 17 February 2006

  • Edition Number: 1

  • Number of Pages: XXII, 411

  • Number of Illustrations: 55 b/w illustrations

  • Topics: Biochemistry, general, Pharmacology/Toxicology, Cell Biology, Oncology, Life Sciences, general

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