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Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling

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Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles

Conclusions

Thus, a spectrum of signalling pathways both regulate mitochondria-derived RONS in the cytosol and are downstream targets of RONS. This creates the potential for a positive feedback amplification loop, significantly impacting the rate of apoptosis. In addition, the observations that several of these pathways may promote or suppress apoptosis and are regulated by RONS further suggests that the ultimate survival of a cell is dependent on the redox state of the intracellular environment.

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Authors
  1. Cecilia Giulivi
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  2. Merry Jo Oursler
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Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Henry Jay Forman

  2. University of California at Los Angeles, Los Angeles, California, USA

    Jon Fukuto

  3. Childrens Hospital Los Angeles Research Institute, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA

    Martine Torres

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© 2003 Kluwer Academic Publishers

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Giulivi, C., Oursler, M.J. (2003). Role of Mitochondrial Oxygen and Nitrogen Reactive Species in Signaling. In: Forman, H.J., Fukuto, J., Torres, M. (eds) Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles. Springer, Dordrecht. https://doi.org/10.1007/0-306-48412-9_17

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  • DOI: https://doi.org/10.1007/0-306-48412-9_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1117-7

  • Online ISBN: 978-0-306-48412-4

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