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Effects of Tris(p-Aminophenyl)-Carbonium Salts and Related Compounds on Experimental Schistosomiasis and Paragonimiasis

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Abstract

IN 1952, we initiated a programme directed toward the synthesis and biological evaluation of a variety of triphenylmethane derivatives as potential schistosomicides in the hope that a useful curative drug could be developed. To date, more than two hundred have been tested in albino mice and several in rhesus monkeys experimentally infected with a Puerto Rican strain of Schistosoma mansoni. Several compounds have also been tested against the lung fluke Paragonimus kellicotti in dogs. In the summary presented below, all amounts of drug are expressed as carbonium ion.

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Author notes

  1. H. NAJARIAN

    Present address: Department of Microbiology, University of Texas Medical Center, Galveston, Texas

Authors and Affiliations

  1. Department of Chemistry,

    E. F. ELSLAGER, F. W. SHORT & D. F. WORTH

  2. Department of Pharmacology, Research Laboratories, Parke, Davis and Co., Ann Arbor, Michigan

    J. E. MEISENHELDER, H. NAJARIAN & P. E. THOMPSON

Authors
  1. E. F. ELSLAGER
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  2. F. W. SHORT
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  3. D. F. WORTH
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  4. J. E. MEISENHELDER
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  5. H. NAJARIAN
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  6. P. E. THOMPSON
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ELSLAGER, E., SHORT, F., WORTH, D. et al. Effects of Tris(p-Aminophenyl)-Carbonium Salts and Related Compounds on Experimental Schistosomiasis and Paragonimiasis. Nature 190, 628–629 (1961). https://doi.org/10.1038/190628a0

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