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Stem Cell Therapy and Administration Routes After Stroke

  • SI: Challenges and Controversies in Translational Stroke Research
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Abstract

Cell-based therapy has demonstrated safety and efficacy in experimental animal models of stroke, as well as safety in stroke patients. However, various questions remain regarding the therapeutic window, dosage, route of administration, and the most appropriate cell type and source, as well as mechanisms of action and immune-modulation to optimize treatment based on stem cell therapy. Various delivery routes have been used in experimental stroke models, including intracerebral, intraventricular, subarachnoid, intra-arterial, intraperitoneal, intravenous, and intranasal routes. From a clinical point of view, it is necessary to demonstrate which is the most feasible, safest, and most effective for use with stroke patients. Therefore, further experimental studies concerning the safety, efficacy, and mechanisms of action involved in these therapeutic effects are required to determine their optimal clinical use.

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Acknowledgments

We would like to thank Juliette Siegfried at ServingMed.com for linguistic assistance. Supported by research grants PS12/01754, INVICTUS (RD12/0014/0006) (Spanish Neurovascular Network) from the Research Institute Carlos III, Spanish Ministry of Science and Innovation and European Regional Development Fund.

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    1. Department of Neurology and Stroke Center, Neuroscience and Cerebrovascular Research Laboratory, Neuroscience Area of IdiPAZ (Health Research Institute), Autonomous University of Madrid, La Paz University Hospital, Paseo de la Castellana 261, 28046, Madrid, Spain

      Berta Rodríguez-Frutos, Laura Otero-Ortega, María Gutiérrez-Fernández, Blanca Fuentes, Jaime Ramos-Cejudo & Exuperio Díez-Tejedor

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    Berta Rodríguez-Frutos, Laura Otero-Ortega and María Gutiérrez-Fernández contributed equally to this work.

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    Rodríguez-Frutos, B., Otero-Ortega, L., Gutiérrez-Fernández, M. et al. Stem Cell Therapy and Administration Routes After Stroke. Transl. Stroke Res. 7, 378–387 (2016). https://doi.org/10.1007/s12975-016-0482-6

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