Abstract
Gastric cancer is one of the most commonplace and lethal cancers in the world. Molecular investigation of this disease, in order to obtain diagnostic and treatments achievements is important and vital. Relatively, in this research study, one of the most important epigenetic factors, the methylation of CDX2 gene was investigated in tumoral and non-tumoral tissues of gastric cancer patients by bisulfite treatment followed by sequencing of the 5’UTR region of CDX2 in both tissues. The results indicated a hypomethylation in tumoral tissues of adenocarcinoma. Consequently, the methylation amount of CDX2 in tumoral tissues was significantly reduced compared with non-tumoral tissues.
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Highlights
• Fluctuation of epigenetic modifications of CDX2 regulatory region was observed in gastric adenocarcinoma.
• CDX2 becomes hypomethylated in gastric cancer.
• Specific CpG positions of 5’UTR of CDX2 are prone to hypomethylation.
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Samadani, A.A., Nikbakhsh, N., Pilehchian, M. et al. Epigenetic changes of CDX2 in gastric adenocarcinoma. J. Cell Commun. Signal. 10, 267–272 (2016). https://doi.org/10.1007/s12079-016-0327-9
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DOI: https://doi.org/10.1007/s12079-016-0327-9