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Synthesis of Potential Pharmaceutical Heterocycles as Surface Active Agents

  • Original Article
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Journal of Surfactants and Detergents

Abstract

Isoxazole, pyrazole, pyran, pyridine and pyrimidine derivatives of fatty acids were synthesized as surface and bioactive heterocycles. Hydroxylation of these intermediates by propylene oxide produced easy-to-handle, efficient and quickly biodegradable surface active agents, which revealed the importance of their applications in safety for humans as well as the environment. These compounds showed good activity against bacteria and fungi, showing promise in applications of drugs, cosmetics, and pesticides.

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Authors and Affiliations

  1. Chemistry Department, College of Applied Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia

    Hamida O. Howsaway & Refat El-Sayed

  2. Chemistry Department, Faculty of Science, Benha University, Banha, Egypt

    Refat El-Sayed

Authors
  1. Hamida O. Howsaway
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  2. Refat El-Sayed
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Correspondence to Refat El-Sayed.

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Howsaway, H.O., El-Sayed, R. Synthesis of Potential Pharmaceutical Heterocycles as Surface Active Agents. J Surfact Deterg 20, 681–694 (2017). https://doi.org/10.1007/s11743-017-1936-x

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  • DOI: https://doi.org/10.1007/s11743-017-1936-x

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