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Syntheses and biological activity of chalcones-imidazole derivatives

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Abstract

A number of novel 13-membered chalcone-imidazole derivatives were prepared and have been synthesized and characterized by IR, 1H NMR, 13C NMR and elemental analysis, the results conformed well to expected structures. Substituted acetophenones and benzaldehydes were condensed using the Claisen–Schmidt base-catalyzed aldol condensation. Methyl on the aromatic ring of chalcones was brominated by NBS, and then the resulting mixture was reacted with imidazole to get the target compound. Several chalcones showed in vitro antibacterial activity against Gram-bacterial. The results showed that these are potential antibacterial compounds.

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Acknowledgment

We are grateful to the Microbiology Institute of the Fourth Military Medical University of China for providing the experiment strains.

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  1. Key Laboratory of Auxiliary Chemistry and Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science and Technology, Xi’an, 710021, China

    Yu-Ting Liu, Xiao-Ming Sun, Da-Wei Yin & Fang Yuan

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  1. Yu-Ting Liu
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  2. Xiao-Ming Sun
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Correspondence to Yu-Ting Liu.

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Liu, YT., Sun, XM., Yin, DW. et al. Syntheses and biological activity of chalcones-imidazole derivatives. Res Chem Intermed 39, 1037–1048 (2013). https://doi.org/10.1007/s11164-012-0665-z

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