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Synthesis of Ecofriendly Functionalized Oxadiazole, Imidazole, Triazole and Pyridine Derivatives

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Journal of Surfactants and Detergents

Abstract

5-Pentadecyl-1,3,4-oxadiazol-2-amine (2) was employed as key intermediate for the synthesis of some new functionalized five and six membered heterocyclic derivatives. The synthesized compounds were reacted with propylene oxide to obtain surface active agents having good surface activity, high solubility in water and good biodegradability. Moreover, the functionalized surfactants showed good antimicrobial activity against gram negative and gram positive organisms. The new compounds are easily synthesized, economical and environmentally friendly and are expected to constitute an important class of organic compounds for medicinal purposes in the future.

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Acknowledgments

Authors would like to thank the staff of the Microbiology Department, Faculty of Science, Umm Al-Qura University for biological activity screening of the tested compounds.

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Authors and Affiliations

  1. Chemistry Department, College of Applied Sciences, Umm Al-Qura University, Makkah, 21955, Saudi Arabia

    Refat El-Sayed, Amani Shaldom & Layla Al Mazrouee

  2. Chemistry Department, Faculty of Science, Benha University, Benha, Egypt

    Refat El-Sayed

Authors
  1. Refat El-Sayed
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  2. Amani Shaldom
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  3. Layla Al Mazrouee
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Correspondence to Refat El-Sayed.

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El-Sayed, R., Shaldom, A. & Mazrouee, L.A. Synthesis of Ecofriendly Functionalized Oxadiazole, Imidazole, Triazole and Pyridine Derivatives. J Surfact Deterg 19, 325–335 (2016). https://doi.org/10.1007/s11743-015-1768-5

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  • DOI: https://doi.org/10.1007/s11743-015-1768-5

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