Special Issue Article

Nanoscale Research Letters

, 5:494

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Finite-Element Modelling of Biotransistors

  • MW ShinwariAffiliated withDepartment of Electrical Engineering, McMaster University Email author 
  • , MJ DeenAffiliated withDepartment of Electrical Engineering, McMaster University
  • , PR SelvaganapathyAffiliated withDepartment of Mechanical Engineering, McMaster University


Current research efforts in biosensor design attempt to integrate biochemical assays with semiconductor substrates and microfluidic assemblies to realize fully integrated lab-on-chip devices. The DNA biotransistor (BioFET) is an example of such a device. The process of chemical modification of the FET and attachment of linker and probe molecules is a statistical process that can result in variations in the sensed signal between different BioFET cells in an array. In order to quantify these and other variations and assess their importance in the design, complete physical simulation of the device is necessary. Here, we perform a mean-field finite-element modelling of a short channel, two-dimensional BioFET device. We compare the results of this model with one-dimensional calculation results to show important differences, illustrating the importance of the molecular structure, placement and conformation of DNA in determining the output signal.


Biosensor Microarray DNA Model Sensitivity