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Decreased Deformation in Asymptomatic Children with Isolated Left Ventricular Non-compaction and Normal Ejection Fraction

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Abstract

Echocardiography is the mainstay of screening and disease surveillance in isolated left ventricular non-compaction (iLVNC). The aim of our study is to determine the early regional and global myocardial functional changes and whether the myocardial changes that cannot be detected by conventional echocardiography could be detected by tissue Doppler imaging (TDI) or two-dimensional speckle-tracking echocardiography (STE) in iLVNC cases without symptoms. Longitudinal and circumferential strain (S) and strain rates (SR) as determined by STE in 20 children aged 12.1 ± 3.3 years was compared with those in 20 controls. All children underwent echocardiographic assessment using two-dimensional, tissue Doppler and speckle-tracking echocardiography. iLVNC patients who had normal systolic function by ejection and shortening fractions were included in this study. According to the TDI in all three segments [the non-compacted (NC), neighboring NC (NNC) and compacted (C) segments], isovolumic contraction time, isovolumic relaxation time and myocardial performance index values were significantly higher, while ejection time were significantly lower in the iLVNC group. According to STE in two segments (NC and NNC-segments) longitudinal S and SR values and also circumferential S and SR values were significantly lower in the iLVNC group compared with the control group; whereas, in the global measurements both longitudinal and circumferential S and SR values in all three segments were significantly lower in the iLVNC group compared with the control group. We believe that TDI and STE that evaluates myocardial deformation can be used for the detection of early myocardial dysfunction in the iLVNC patients who are subclinical and whose left ventricular functions were detected as normal by conventional methods with normal ejection and shortening fractions.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Ankara Children’s Hematology and Oncology Research and Training Hospital, Ziraat Mah. Irfan Bastug Cad. Kurtdereli Sok. No: 10 Dışkapı/Altındag, Ankara, Turkey

    Mehmet Emre Ari, Ibrahim Ilker Cetin, Abdullah Kocabas, Filiz Ekici & Murat Surucu

  2. Department of Pediatric Cardiology, Dr. Sami Ulus Obstetrics and Gynecology, Children’s Health and Diseases Training and Research Hospital, Ankara, Turkey

    Ozben Ceylan

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  1. Mehmet Emre Ari
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  2. Ibrahim Ilker Cetin
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  3. Abdullah Kocabas
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  5. Ozben Ceylan
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  6. Murat Surucu
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Correspondence to Mehmet Emre Ari.

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Ari, M.E., Cetin, I.I., Kocabas, A. et al. Decreased Deformation in Asymptomatic Children with Isolated Left Ventricular Non-compaction and Normal Ejection Fraction. Pediatr Cardiol 37, 201–207 (2016). https://doi.org/10.1007/s00246-015-1266-6

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  • DOI: https://doi.org/10.1007/s00246-015-1266-6

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