Skip to main content
SpringerLink
Log in

Systolic-diastolic coupling of myocardial deformation of the left ventricle in children with left ventricular noncompaction

  • Original Article
  • Published:
Heart and Vessels Aims and scope Submit manuscript

Abstract

Disruption of the myocardial architecture in left ventricular noncompaction (LVNC) may alter myocardial deformation. We evaluated LV myocardial deformation and tested the hypothesis that tight systolic-diastolic coupling occurs in LVNC. Longitudinal and circumferential strain and strain rates (SRs) as determined by speckle tracking echocardiography in nine children aged 5.6 ± 5.5 years was compared with those in nine controls. Left ventricular systolic myocardial deformation parameters were correlated with ejection fraction and indices of diastolic deformation. Compared with controls, patients had lower global LV systolic longitudinal strain (P = 0.008), systolic SR (P = 0.05) and early diastolic SR (P < 0.001). Similarly, LV systolic circumferential strain (base, P = 0.04; papillary muscle level, P = 0.01; apex, P = 0.04), systolic SR (base, P = 0.04) and early diastolic SR (papillary muscle level, P = 0.004, apex, P = 0.02) were lower in patients than in controls. Among patients, the LV ejection fraction correlated with global longitudinal systolic strain and SR and circumferential systolic strain and SR at all levels (all P < 0.05). Positive correlations existed between early diastolic and systolic SRs in corresponding dimensions (longitudinal r = 0.80, P = 0.01; circumferential at base, r = 0.91, P = 0.001; papillary muscle level, r = 0.96, P < 0.001; apex r = 0.98, P = <0.001). In conclusion, LV myocardial deformation is reduced in the longitudinal and circumferential dimensions and manifests tight systolic-diastolic coupling in children with LVNC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Zambrano E, Marshalko SJ, Jaffe CC, Hui P (2002) Isolated noncompaction of the ventricular myocardium: clinical and molecular aspects of a rare cardiomyopathy. Lab Investig 82:117–122

    PubMed  Google Scholar 

  2. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z (2004) Two-dimensional strain—a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr 17:1021–1029

    Article  PubMed  Google Scholar 

  3. Eichhorn EJ, Willard JE, Alvarez L, Kim AS, Glamann DB, Risser RC, Grayburn PA (1992) Are contraction and relaxation coupled in patients with and without congestive heart failure? Circulation 85:2132–2139

    CAS  PubMed  Google Scholar 

  4. Meluzin J, Spinarova L, Hude P, Krejci J, Poloczkova H, Podrouzkova H, Pesl M, Orban M, Dusek L, Korinek J (2009) Left ventricular mechanics in idiopathic dilated cardiomyopathy: systolic-diastolic coupling and torsion. J Am Soc Echocardiogr 22:486–493

    Article  PubMed  Google Scholar 

  5. De Hert SG, Gillebert TC, Ten Broecke PW, Mertens E, Rodrigus IE, Moulijn AC (1999) Contraction–relaxation coupling and impaired left ventricular performance in coronary surgery patients. Anesthesiology 90:748–757

    Article  PubMed  Google Scholar 

  6. Jenni R, Oechslin E, Schneider C, Jost CA, Kaufmann PA (2001) Echocardiographic and pathoanatomical characteristics of isolated left ventricular non-compaction: a step towards classification as a distinct cardiomyopathy. Heart 86:666–671

    Article  CAS  PubMed  Google Scholar 

  7. Fazio G, Pipitone S, Iacona MA, Marchì S, Mongiovì M, Zito R, Sutera L, Novo S (2007) The noncompaction of the left ventricular myocardium: our paediatric experience. J Cardiovasc Med 8:904–908

    Article  Google Scholar 

  8. Koh C, Lee PW, Lun KS, Yung TC, Cheung YF (2009) Left ventricular noncompaction in children. Congenit Heart Dis 4:288–294

    Article  PubMed  Google Scholar 

  9. McMahon CJ, Pignatelli RH, Nagueh SF, Lee VV, Vaughn W, Valdes SO, Kovalchin JP, Jefferies JL, Dreyer WJ, Denfield SW, Clunie S, Towbin JA, Eidem BW (2007) Left ventricular non-compaction cardiomyopathy in children: characterisation of clinical status using tissue Doppler-derived indices of left ventricular diastolic relaxation. Heart 93:676–681

    Article  PubMed  Google Scholar 

  10. Pignatelli RH, McMahon CJ, Dreyer WJ, Denfield SW, Price J, Belmont JW, Craigen WJ, Wu J, El Said H, Bezold LI, Clunie S, Fernbach S, Bowles NE, Towbin JA (2004) Clinical characterization of left ventricular noncompaction in children: a relatively common form of cardiomyopathy. Circulation 108:2672–2678

    Article  Google Scholar 

  11. Aras D, Tufekcioglu O, Ergun K, Ozeke O, Yildiz A, Topaloglu S, Deveci B, Sahin O, Kisacik HL, Korkmaz S (2006) Clinical features of isolated ventricular noncompaction in adults: long-term clinical course, echocardiographic properties, and predictors of left ventricular failure. J Card Fail 12:726–733

    Article  PubMed  Google Scholar 

  12. Oechslin EN, Jost CHA, Rojas JR, Kaufmann PA, Jenni R (2000) Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 36:493–500

    Article  CAS  PubMed  Google Scholar 

  13. van Dalen BM, Caliskan K, Soliman OI, Nemes A, Vletter WB, Ten Cate FJ, Geleijnse ML (2008) Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and quantitative functional diagnostic criterion? Eur J Heart Fail 10:1088–1093

    Article  PubMed  Google Scholar 

  14. Greenberg NL, Firstenberg MS, Castro PL, Main M, Travaglini A, Odabashian JA, Drinko JK, Rodriguez LL, Thomas JD, Garcia MJ (2002) Doppler-derived myocardial systolic strain rate is a strong index of left ventricular contractility. Circulation 105:99–105

    Article  PubMed  Google Scholar 

  15. Jamal F, Bergerot C, Argaud L, Loufouat J, Ovize M (2003) Longitudinal strain rate quantitates regional right ventricular contractile function. Am J Physiol Heart Circ Physiol 285:H2842–H2847

    CAS  PubMed  Google Scholar 

  16. Pellerin D, Sharma R, Elliot P, Veyrat C (2003) Tissue Doppler, strain, and strain rate echocardiography for the assessment of left and right systolic ventricular function. Heart 89(Suppl III):III9–III17

    PubMed  Google Scholar 

  17. Reisner SA, Lysyansky P, Agmon Y, Mutlak D, Lessick J, Friedman Z (2004) Global longitudinal strain: a novel index of left ventricular systolic function. J Am Soc Echocardiogr 17:630–633

    Article  PubMed  Google Scholar 

  18. Serri K, Reant P, Lafitte M, Berhouet M, Le Bouffos V, Roudaut R, Lafitte S (2006) Global and regional myocardial function quantification by two-dimensional strain. J Am Coll Cardiol 47:1175–1181

    Article  PubMed  Google Scholar 

  19. Tanaka H, Oishi Y, Mizuguchi Y, Emi S, Ishimoto T, Nagase N, Tabata T, Yamada H, Oki T (2007) Three-dimensional evaluation of dobutamine-induced changes in regional myocardial deformation in ischemic myocardium using ultrasonic strain measurements: the role of circumferential myocardial shortening. J Am Soc Echocardiogr 20:1294–1299

    Article  PubMed  Google Scholar 

  20. Fazio G, Corrado G, Novo G, Zachara E, Rapezzi C, Sulafa AK, Sutera L, D’angelo L, Visconti C, Stollberger C, Sormani L, Finsterer J, Cavusoglu Y, Di Gesaro G, Grassedonio E, Ferrara F, Galia M, Midiri M, Pipitone S, Carerj S, Novo S (2009) Ventricular dysfunction and number of non compacted segments in non compaction: non-independent predictors. Int J Cardiol. doi:10.1016/j.ijcard.2008.11.199

  21. Nemes A, Caliskan K, Geleijnse ML, Soliman OI, Vletter WB, ten Cate FJ (2009) Reduced regional systolic function is not confined to the noncompacted segments in noncompaction cardiomyopathy. Int J Cardiol 134:366–370

    Article  PubMed  Google Scholar 

  22. Fazio G, Pipitone S, Iacona MA, Marchì S, Mongiovì M, Zito R, Sutera L, Novo G, Novo S (2007) Evaluation of diastolic function by the tissue Doppler in children affected by non-compaction. Int J Cardiol 116:e60–e62

    Article  PubMed  Google Scholar 

  23. Palecek T, Linhart A (2007) Comparison of early diastolic annular velocities measured at various sites of mitral annulus in detection of mild to moderate left ventricular diastolic dysfunction. Heart Vessels 22:67–72

    Article  PubMed  Google Scholar 

  24. Kim H, Cho H-O, Cho Y-K, Nam C-W, Han S-W, Hur S-H, Kim K-S, Kim Y-N, Kim K-B (2008) Relationship between early diastolic strain rate imaging and left ventricular geometric patterns in hypertensive patients. Heart Vessels 23:271–278

    Article  PubMed  Google Scholar 

  25. Morgan JP, Erny RE, Allen PD, Grossman W, Gwathmey JK (1990) Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 81(2 Suppl):III21–III32

    CAS  PubMed  Google Scholar 

  26. Minamisawa S, Sato Y, Cho MC (2004) Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias. Exp Mol Med 36:193–203

    CAS  PubMed  Google Scholar 

  27. Shou W, Aghdasi B, Armstrong DL, Guo Q, Bao S, Charng MJ, Mathews LM, Schneider MD, Hamilton SL, Matzuk MM (1998) Cardiac defects and altered ryanodine receptor function in mice lacking FKFP12. Nature 39:489–492

    Google Scholar 

Download references

Author information

Author notes

  1. C. Koh

    Present address: Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong, China

Authors and Affiliations

  1. Division of Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, China

    C. Koh, W. J. Hong, S. J. Wong & Y. F. Cheung

Authors
  1. C. Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. J. Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. J. Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. F. Cheung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Y. F. Cheung.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Koh, C., Hong, W.J., Wong, S.J. et al. Systolic-diastolic coupling of myocardial deformation of the left ventricle in children with left ventricular noncompaction. Heart Vessels 25, 493–499 (2010). https://doi.org/10.1007/s00380-010-0001-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00380-010-0001-8

Keywords

Search

Navigation