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Bioelectroanalysis of pharmaceutical compounds

  • Published:
Bioanalytical Reviews

Abstract

Recent developments in the bioelectroanalysis of pharmaceutical compounds are reviewed, concentrating particularly on the development of electrode materials and measurement strategies and on their application. The advantages of electroanalytical techniques as alternatives to other analytical procedures such as rapid response, sensitivity and low detection limits are highlighted and illustrated. Particular emphasis is given to carbon-based materials for voltammetric electroanalysis; new potentiometric sensors and electrochemical biosensors are also reviewed.

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References

  1. Franklin RE (1951) Crystallite growth in graphitizing and non-graphitizing carbons. Proc R Soc Lond A 209:196–218

    Article  CAS  Google Scholar 

  2. Jenkins GM, Kawamura K (1971) Structure of glassy carbon. Nature 231:175–176

    Article  CAS  Google Scholar 

  3. Harris PJF (2004) Fullerene-related structure of commercial glassy carbons. Phil Mag 84:3159–3167

    Article  CAS  Google Scholar 

  4. McCreery RL (1991) Carbon electrodes: structural effects on electron transfer kinetics. In: Bard AJ (ed) Electroanalytical chemistry, vol 17. Dekker, New York, pp 221–274

    Google Scholar 

  5. Brett CMA, Oliveira-Brett AM (1993) Electrochemistry, principles, methods and applications. Oxford University Press, UK

    Google Scholar 

  6. Uslu B, Ozkan SA (2004) Anodic voltammetry of abacavir and its determination in pharmaceuticals and biological fluids. Electrochim Acta 49:4321–4329

    Article  CAS  Google Scholar 

  7. Silva MLS, Garcia MBQ, Lima JLFC, Barrado E (2006) Modified tubular electrode in a multi-commutated flow system: determination of acetaminophen in blood serum and pharmaceutical formulations. Anal Chim Acta 573–574:383–390

    Article  CAS  Google Scholar 

  8. Piedade JA, Fernandes IR, Oliveira-Brett AM (2002) Electrochemical sensing of DNA–adriamycin interactions. Bioelectrochemistry 56:81–83

    Article  CAS  Google Scholar 

  9. Oliveira-Brett AM, Vivan M, Fernandes IR, Piedade JAP (2002) Electrochemical detection of in situ adriamycin oxidative damage to DNA. Talanta 56:959–970

    Article  CAS  Google Scholar 

  10. Oliveira-Brett AM, Piedade JAP, Chiorcea A-M (2002) Anodic voltammetry and AFM imaging of picomoles of adriamycin adsorbed onto carbon surfaces. J Electroanal Chem 538–539:267–276

    Google Scholar 

  11. Uslu B (2002) Voltammetric analysis of alfuzosin HCl in pharmaceuticals, human serum and simulated gastric juice. Electroanalysis 14:866–870

    Article  CAS  Google Scholar 

  12. Demircigil BT, Uslu B, Ozkan Y, Ozkan SA, Senturk Z (2003) Voltammetric oxidation of ambroxol and application to its determination in pharmaceutical and in drug dissolution studies. Electroanalysis 15:481–489

    Article  Google Scholar 

  13. Ozkan SA, Uslu B, Senturk Z (2004) Electroanalytical characteristics of amisulpride and voltammetric determination of the drug in pharmaceuticals and biological media. Electroanalysis 16:231–237

    Article  CAS  Google Scholar 

  14. Gazy AAK (2004) Determination of amlodipine besylate by adsorptive square wave anodic stripping voltammetry on glassy carbon electrode in tablets and biological fluids. Talanta 62:575–582

    Article  CAS  Google Scholar 

  15. Dogan-Topal B, Bozal B, Demircigil BT, Uslu B, Ozkan SA (2009) Electroanalytical studies and simultaneous determination of amlodipidine besylate and atorvastatine calcium in binary mixtures using first derivative of radio-voltammetric methods. Electroanalysis 21:2427–2439

    CAS  Google Scholar 

  16. Garrido JMPJ, Delerue-Matos C, Borges MFM, Macedo TRA, Oliveira-Brett AM (2002) Oxidative behaviour of apomorphine and its metabolites. Bioelectrochemistry 55:113–114

    Article  CAS  Google Scholar 

  17. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2003) Flow injection electrochemical determination of apomorphine. Anal Lett 36:2199–2210

    Article  CAS  Google Scholar 

  18. Erdurak-Kiliç CS, Uslu B, Dogan B, Ozgen U, Ozkan SA, Coskun M (2006) Anodic voltammetric behavior of ascorbic acid and its selective determination in pharmaceutical dosage forms and some Rosa species of Turkey. J Anal Chem 61:1113–1120

    Article  CAS  Google Scholar 

  19. Goyal RN, Singh SP (2006) Voltammetric determination of atenolol at C60-modified glassy carbon electrodes. Talanta 69:932–937

    Article  CAS  Google Scholar 

  20. Pérz-Ortiz M, Munõz C, Zapata-Urzúa C, Álvarez-Lueje A (2010) Electrochemical behavior of atomoxetine and its voltammetric determination in capsules. Talanta 82:398–403

    Article  CAS  Google Scholar 

  21. Dogan-Topal B, Uslu B, Ozkan SA (2007) Investigation of electrochemical behavior of lipid lowering agent atorvastatin calcium in aqueous media and its determination from pharmaceutical dosage forms and biological fluids using boron-doped diamond and glassy carbon electrodes. Comb Chem High T Scr 10:571–582

    CAS  Google Scholar 

  22. Nigovi B, Simunic B (2003) Voltammetric assay of azithromycin in pharmaceutical dosage forms. J Pharm Biomed Anal 32:197–202

    Article  CAS  Google Scholar 

  23. Palomeque ME, Ortiz PI (2007) New automatized method with amperometric detection for the determination of azithromycin. Talanta 72:101–105

    Article  CAS  Google Scholar 

  24. Biryol I, Ozkan SA (1997) Voltammetric determination of droperidol and benperidol. J Pharm Biomed Anal 15:1695–1701

    Article  CAS  Google Scholar 

  25. La-Scalea MA, Serrano SHP, Ferreira EI, Oliveira-Brett AM (2002) Voltammetric behavior of benznidazole at a DNA-electrochemical biosensor. J Pharm Biomed Anal 29:561–568

    Article  CAS  Google Scholar 

  26. Diculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2009) Electrochemical oxidation of berberine and of its oxidation products at a glassy carbon electrode. Electroanalysis 21:1027–1034

    Article  CAS  Google Scholar 

  27. Turchán M, Jara-Ulloa P, Bollo S, Nuñez-Vergara LJ, Sequella JA, Álvarez-Lueje A (2007) Voltammetric behaviour of bromhexine and its determination in pharmaceuticals. Talanta 73:913–919

    Article  CAS  Google Scholar 

  28. Radi A, El-Shahawi MS, Elmogy T (2005) Differential pulse voltammetric determination of the dopaminergic agonist bromocriptine at glassy carbon electrode. J Pharm Biomed Anal 37:195–198

    Article  CAS  Google Scholar 

  29. Garcia-Fernandez MA, Fernandez-Abedul MT, Costa-Garcia A (2000) Determination of buprenorphine in pharmaceuticals and human urine by adsorptive stripping voltammetry in batch and flow systems. Electroanalysis 12:483–489

    Article  CAS  Google Scholar 

  30. Dogan B, Uslu B, Ozkan SA (2004) Anodic stripping voltammetry of the hypertensive drug candesartan cilexetil at the glassy carbon electrode. Pharmazie 11:840–844

    Google Scholar 

  31. Dogan B, Ozkan SA (2005) Electrochemical behavior of carvedilol and its adsorptive stripping determination in dosage forms and biological fluids. Electroanalysis 17:2074–2083

    Article  CAS  Google Scholar 

  32. Ziyatdinova GK, Budnikov GK (2005) Determination of some catecholamines by coulometric titration and cyclic voltammetry. J Anal Chem 60:673–677

    Article  CAS  Google Scholar 

  33. Ozkan SA, Erk N, Uslu B, Yılmaz N, Biryol I (2000) Study on electrooxidation of cefadroxil monohydrate and its determination by differential pulse voltammetry. J Pharm Biomed Anal 23:263–273

    Article  CAS  Google Scholar 

  34. Golcu A, Dogan B, Ozkan SA (2005) Anodic voltammetric behavior and determination of cefixime in pharmaceutical dosage forms and biological fluids. Talanta 67:703–712

    Article  CAS  Google Scholar 

  35. Dogan B, Golcu A, Ozkan SA (2009) Electrochemical behavior of the bactericidal cefoperazone and its selective voltammetric determination in pharmaceutical dosage forms and human serum. Curr Pharm Anal 5:179–189

    Article  CAS  Google Scholar 

  36. Dogan B, Golcu A, Dolaz M, Ozkan SA (2009) Anodic oxidation of antibacterial drug cefotaxime sodium and its square wave and differential pulse determination in pharmaceuticals and human serum. Curr Pharm Anal 5:197–207

    Article  CAS  Google Scholar 

  37. El-Maali NA (2000) Voltammetric analysis of ceftazidime after preconcentration at various mercury and carbon electrodes: application to sub-ppb level determination in urine samples. Talanta 51:957–968

    Article  CAS  Google Scholar 

  38. Torriero AAJ, Ruiz-Diaz JJJ, Salinas E, Marcevsky EJ, Sanz MI, Raba J (2006) Enzymatic rotating biosensor for ciprofloxacin determination. Talanta 69:691–699

    Article  CAS  Google Scholar 

  39. El-Sayed GO, Yasin SA, El-Badawy AA (2008) Voltammetric behavior and determination of cinnarizine in pharmaceutical formulations and serum. Anal Lett 41:3021–3033

    Article  CAS  Google Scholar 

  40. Satana E, Uslu B, Ozkan SA (2002) Differential pulse and square wave voltammetric determination of cisapride in tablet dosage form. Pharmazie 57:501–503

    CAS  Google Scholar 

  41. Nouws HPA, Delerue-Matos C, Barros AA, Maesen E, Moreira SCPA, Neves MMPS (2008) Static and hydrodynamic monitoring of citalopram based on its electro-oxidation behavior at a glassy-carbon surface. Anal Lett 41:2171–2185

    Article  CAS  Google Scholar 

  42. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2002) Electroanalytical determination of codeine in pharmaceutical preparation. Anal Lett 35:2487–2498

    Article  CAS  Google Scholar 

  43. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2003) Electrochemical determination of dihydrocodeine in pharmaceuticals. Anal Lett 36:577–590

    Article  CAS  Google Scholar 

  44. Bezerra VS, Lima Filho JL, Montenegro MCBSM, Araujo AN, Silva VL (2003) Flow-injection amperometric determination of dopamine in pharmaceuticals using a polyphenol oxidase biosensor obtained from soursop pulp. J Pharm Biomed Anal 33:1025–1031

    Article  CAS  Google Scholar 

  45. Diculescu VC, Enache TA, Oliveira-Brett AM (2007) Electrochemical oxidation at a glassy carbon electrode of the anti-arrhythmia drug disopyramide. Anal Lett 40:2860–2871

    Article  CAS  Google Scholar 

  46. Sun XX, Aboul-Enein HY (2002) Internal solid contact sensor for the determination of doxycycline hydrochloride in pharmaceutical formulation. Talanta 58:387–396

    Article  CAS  Google Scholar 

  47. Navalon A, Blanc R, Reyes L, Navas N, Vilchez JL (2002) Determination of the antibacterial enrofloxacin by differential pulse adsorptive stripping voltammetry. Anal Chim Acta 454:83–91

    Article  CAS  Google Scholar 

  48. Yılmaz S, Uslu B, Ozkan SA (2001) Anodic oxidation of etodolac and its square wave and differential pulse voltammetric determination in pharmaceutical and human serum. Talanta 54:351–360

    Article  Google Scholar 

  49. Salcı B, Biryol I (2002) Voltammetric investigation of β-estradiol. J Pharm Biomed Anal 28:753–759

    Article  Google Scholar 

  50. Golcu A, Dogan B, Ozkan SA (2005) Anodic voltammetric behavior and determination of antihistaminic agent: fexofenadine HCl. Anal Lett 38:1913–1931

    Article  CAS  Google Scholar 

  51. Uslu B, Yılmaz N, Erk N, Ozkan SA, Senturk Z, Biryol I (1999) The study of the voltammetric behavior of flunarizine. J Pharm Biomed Anal 21:215–220

    Article  CAS  Google Scholar 

  52. Dogan B, Ozkan SA, Uslu B (2005) Electrochemical characterization of flupenthixol and rapid determination of the drug in human serum and pharmaceuticals by voltammetry. Anal Lett 38:641–656

    Article  CAS  Google Scholar 

  53. Senturk Z, Ozkan SA, Uslu B, Biryol I (1996) Anodic voltammetry of fluphenazine at different solid electrodes. J Pharm Biomed Anal 15:365–370

    Article  CAS  Google Scholar 

  54. Ozkan SA, Uslu B (2002) Electrochemical study of fluvastatin sodium analytical application to pharmaceutical dosage forms, human serum, and simulated gastric juice. Anal Bioanal Chem 372:582–586

    Article  CAS  Google Scholar 

  55. Demircigil BT, Ozkan SA, Coruh O, Yılmaz S (2002) Electrochemical behavior of formoterol fumarate and its determination in capsules for inhalation and human serum using differential-pulse and square-wave voltammetry. Electroanalysis 14:122–127

    Article  CAS  Google Scholar 

  56. Uslu B, Dogan B, Ozkan SA (2005) Electrochemical studies of ganciclovir at glassy carbon electrodes and its direct determination in serum and pharmaceutics by square wave and differential pulse voltammetry. Anal Chim Acta 537:307–313

    Article  CAS  Google Scholar 

  57. Diculescu VC, Vivan M, Oliveira-Brett AM (2006) Voltammetric behaviour of anti-leukemia drug glivec. Part I—electrochemical study of glivec. Electroanalysis 18:1800–1807

    Article  CAS  Google Scholar 

  58. Diculescu VC, Vivan M, Oliveira-Brett AM (2006) Voltammetric behaviour of anti-leukemia drug glivec. Part II—redox processes of glivec electrochemical metabolite. Electroanalysis 18:1808–1814

    Article  CAS  Google Scholar 

  59. Diculescu VC, Vivan M, Oliveira-Brett AM (2006) Voltammetric behaviour of anti-leukemia drug glivec. Part III—in situ DNA oxidative damage by the glivec electrochemical metabolite. Electroanalysis 18:1963–1970

    Article  CAS  Google Scholar 

  60. Razak OA (2004) Electrochemical study of hydrochlorothiazide and its determination in urine and tablets. J Pharm Biomed Anal 34:433–440

    Article  CAS  Google Scholar 

  61. Arguelho MLPM, Andrade JF, Stradiotto NR (2003) Electrochemical study of hydroxychloroquine and its determination in plaquenil by differential pulse voltammetry. J Pharm Biomed Anal 32:269–275

    Article  CAS  Google Scholar 

  62. Uslu B, Biryol I (1997) Determination of imipramine hydrochloride in drugs based on voltammetric oxidation at platinum and activated glassy carbon electrodes. STP Pharma Sci 7:248–253

    CAS  Google Scholar 

  63. Dogan B, Canbaz D, Ozkan SA, Uslu B (2006) Electrochemical methods for determination of protease inhibitor indinavir sulfate in pharmaceutics and human serum. Pharmazie 61:409–413

    CAS  Google Scholar 

  64. Süzen S, Ates-Alagöz Z, Demircigil BT, Ozkan SA (2001) Synthesis and analytical evaluation by voltammetric studies of some new indole-3-propionamide derivatives. Il Farmaco 56:835–840

    Article  Google Scholar 

  65. Süzen S, Demircigil BT, Buyukbingol E, Ozkan SA (2003) Electroanalytical evaluation and determination of derivatives by voltammetric studies: possible relevance to in vitro metabolism. New J Chem 27:1007–1011

    Article  CAS  Google Scholar 

  66. Majidi MR, Jouyban A, Asadpour-Zeynali K (2006) Voltammetric behavior and determination of isoniazid in pharmaceuticals by using overoxidized polypyrrole glassy carbon modified electrode. J Electroanal Chem 589:32–37

    Article  CAS  Google Scholar 

  67. Quintino MSM, Angnes L (2006) Fast BIA-amperometric determination of isoniazid in tablets. J Pharm Biomed Anal 42:400–404

    Article  CAS  Google Scholar 

  68. Ozkan SA (2002) Determination of the antihypertensive drug lacidipine in pharmaceuticals using by differential pulse and square wave voltammetry. Pharmazie 57:503–505

    CAS  Google Scholar 

  69. Dogan B, Uslu B, Suzen S, Ozkan SA (2005) Electrochemical evaluation of nucleoside analogue lamivudine in pharmaceutical dosage forms and human serum. Electroanalysis 17:1886–1894

    Article  CAS  Google Scholar 

  70. Radi A, El-Sherif Z (2002) Determination of levofloxacin in human urine by adsorptive square-wave anodic stripping voltammetry on a glassy carbon electrode. Talanta 58:319–324

    Article  CAS  Google Scholar 

  71. Radi A, El Ries MA, Kandil S (2003) Electrochemical study of the interaction of levofloxacin with DNA. Anal Chim Acta 495:61–67

    Article  CAS  Google Scholar 

  72. Quintino MSM, Yamashita M, Angnes L (2006) Voltammetric studies and determination of levodopa and carbidopa in pharmaceutical products. Electroanalysis 18:655–661

    Article  CAS  Google Scholar 

  73. Corduneanu O, Garnett M, Oliveira-Brett AM (2007) Anodic oxidation of α-lipoic acid at a glassy carbon electrode and its determination in dietary supplements. Anal Lett 40:1763–1778

    Article  CAS  Google Scholar 

  74. Dogan-Topal B, Golcu A, Ozkan SA (2009) Electrochemical investigation and determination of the bacterial loracarbet by voltammetric methods. Anal Lett 42:689–705

    Article  CAS  Google Scholar 

  75. Uslu B, Dogan B, Ozkan SA, Aboul-Enein HY (2005) Voltammetric investigation and determination of mefloquine. Electroanalysis 17:1563–1570

    Article  CAS  Google Scholar 

  76. Uslu B, Demircigil BT, Ozkan SA, Senturk Z, Aboul-Enein HY (2001) Simultaneous voltammetric determination of melatonin and pyridoxine HCl in pharmaceutical dosage forms. Pharmazie 56:938–942

    CAS  Google Scholar 

  77. Pontinha ADR, Oliveira SCB, Oliveira-Brett AM (2008) Electrochemical oxidation of metolazone at a glassy carbon electrode. Electroanalysis 20:2531–2536

    Article  CAS  Google Scholar 

  78. Lu SF, Wu KB, Dang XP, Hu SS (2004) Electrochemical reduction and voltammetric determination of metronidazole at a nanomaterial thin film coated glassy carbon electrode. Talanta 63:653–657

    Article  CAS  Google Scholar 

  79. Jiang XH, Lin XQ (2006) Voltammetry of the interaction of metronidazole with DNA and its analytical application. Bioelectrochemistry 68:206–212

    Article  CAS  Google Scholar 

  80. Ozkan SA, Ozkan Y, Sentürk Z (1998) Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms. J Pharm Biomed Anal 17:299–305

    Article  CAS  Google Scholar 

  81. Oliveira-Brett AM, Serrano SHP, Gutz I, La-Scalea MA, Cruz ML (1997) Voltammetric behaviour of nitroimidazoles at a DNA-biosensor. Electroanalysis 9:1132–1137

    Article  CAS  Google Scholar 

  82. Oliveira-Brett AM, Serrano SHP, Gutz I, La-Scalea MA (1997) Electrochemical reduction of metronidazole at a DNA-modified glassy carbon electrode. Bioelectrochem Bioenerg 42:175–178

    Article  CAS  Google Scholar 

  83. Oliveira-Brett AM, Serrano SHP, Gutz I, La-Scalea MA (1997) Comparison of the voltammetric behaviour of metronidazole at a DNA-modified glassy carbon electrode, a mercury film electrode and a glassy carbon electrode. Electroanalysis 9:110–114

    Article  CAS  Google Scholar 

  84. Oliveira-Brett AM, Macedo TRA, Raimundo D, Marques MH, Serrano SHP (1998) Voltammetric behaviour of mitoxantrone at a DNA-biosensor. Biosens Bioelectron 13:861–867

    Article  Google Scholar 

  85. Oliveira-Brett AM, Macedo TRA, Raimundo D, Marques MH, Serrano SHP (1999) Electrochemical oxidation of mitoxantrone at a glassy carbon electrode. Anal Chim Acta 385:401–408

    Article  CAS  Google Scholar 

  86. Oliveira-Brett AM, Grazina MMM, Macedo TRA, Oliveira C, Raimundo D (1993) A study of the electrochemical oxidation of Navelbine. J Pharm Biomed Anal 11:203–206

    Article  Google Scholar 

  87. Oliveira-Brett AM, Grazina MMM, Macedo TRA, Raimundo D (1994) Anodic behavior of some Vinca alkaloids with cytostatic activity: effect of pH. Electroanalysis 6:57–61

    Article  Google Scholar 

  88. Uslu B, Ozkan SA (2002) Electroanalytical characteristics of nefazodone hydrochloride and their application from pharmaceuticals and human serum. Anal Chim Acta 462:49–57

    Article  CAS  Google Scholar 

  89. Abreu FC, Goulart MOF, Oliveira Brett AM (2002) Detection of the damage caused to DNA by niclosamide using an electrochemical DNA-biosensor. Biosen Bioelectron 17:913–919

    Article  CAS  Google Scholar 

  90. Sentürk Z, Ozkan SA, Ozkan Y (1998) Electroanalytical study of nifedipine using activated glassy carbon electrode. J Pharm Biomed Anal 16:801–807

    Article  Google Scholar 

  91. Solangi AR, Khuhawar MY, Bhanger MI (2005) Adsorptive stripping voltammetric determination of fluoroquinolones in pharmaceuticals. J Food Drug Anal 13:201–204

    CAS  Google Scholar 

  92. Uslu B, Yılmaz S, Ozkan SA (2001) Determination of olsalazine sodium in pharmaceuticals by differential pulse voltammetry. Pharmazie 56:629–632

    CAS  Google Scholar 

  93. Jorge SMA, Pontinha ADR, Oliveira-Brett AM (2010) Electrochemical redox behaviour of omeprazole using a glassy carbon electrode. Electroanalysis 22:625–631

    Article  CAS  Google Scholar 

  94. Turhan E, Uslu B (2008) Electroanalytical determination of opipramol in pharmaceutical preparations and biological fluids. Anal Lett 41:2013–2032

    Article  CAS  Google Scholar 

  95. Ozkan SA, Sentürk Z, Biryol I (1997) Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode. Int J Pharm 157:137–144

    Article  Google Scholar 

  96. Ni YN, Wang YR, Kokot S (2004) Differential pulse stripping voltammetric determination of paracetamol and phenobarbital in pharmaceuticals assisted by chemometrics. Anal Lett 37:3219–3235

    Article  CAS  Google Scholar 

  97. Uslu B, Dogan-Topal B, Ozkan SA (2008) Electroanalytical investigation and determination of pefloxacin in pharmaceuticals and serum at boron-doped diamond and glassy carbon electrodes. Talanta 74:1191–1220

    Article  CAS  Google Scholar 

  98. Hegde RN, Nandibewoor ST (2008) Electrochemical oxidation of pentoxifylline and its analysis in pure and pharmaceutical formulations at a glassy carbon electrode. Anal Lett 41:977–991

    Article  CAS  Google Scholar 

  99. Mielech-Łukasiewicz K, Puzanowska-Tarasiewicz H, Panuszko A (2008) Electrochemical oxidation of phenothiazine derivatives at glassy carbon electrodes and their differential pulse and square-wave voltammetric determination in pharmaceuticals. Anal Lett 41:789–805

    Article  CAS  Google Scholar 

  100. Bozkaya P, Dogan B, Suzen S, Nebioglu D, Ozkan SA (2006) Determination and investigation of electrochemical behavior of 2-phenylindole derivatives: discussion on possible mechanistic pathways. Can J Anal Sci Spect 51:125–139

    CAS  Google Scholar 

  101. Ozkan SA, Ozkan Y, Senturk Z (2002) Electrooxidation of pimozide and its differential pulse voltammetric and HPLC-EC determination. Anal Chim Acta 453:221–229

    Article  CAS  Google Scholar 

  102. Uslu B, Ozkan SA (2003) Electroanalytical characteristics of piribedil and its differential pulse and square wave voltammetric determination in pharmaceuticals and human serum. J Pharm Biomed Anal 31:481–489

    Article  CAS  Google Scholar 

  103. Yılmaz S, Skrzypek S, Dilgin Y, Yagmur S, Coskun M (2007) Electrochemical oxidation of prednisolone at glassy carbon electrode and its quantitative determination in human serum and tablets by Osteryoung square wave voltammetry. Curr Anal Chem 3:41–46

    Article  Google Scholar 

  104. Uslu B, Biryol I, Ozkan SA, Senturk Z (1996) Voltammetric determination of promethazine by platinum and glassy carbon electrodes. Tr J Chem 20:323–328

    CAS  Google Scholar 

  105. El-Ries MAN, Mohamed GG, Attia AK (2008) Electrochemical determination of the antidiabetic drug repaglinide. Yakugaku Zasshi 128:171–177

    Article  CAS  Google Scholar 

  106. Ozkan SA, Dogan B, Uslu B (2006) Voltammetric analysis of the novel antipsychotic drug quetiapine in human serum and urine. Microchim Acta 153:27–35

    Article  CAS  Google Scholar 

  107. Uslu B, Ozkan SA, Aboul-Enein HY (2002) Electrochemical study of S-adenosyl-methionine and its differential pulse and square wave voltammetric determination. Electroanalysis 14:736–740

    Article  CAS  Google Scholar 

  108. Quintino MSM, Angnes L (2004) Bia-amperometric quantification of salbutamol in pharmaceutical products. Talanta 62:231–236

    Article  CAS  Google Scholar 

  109. Torriero AAJ, Luco JM, Serono L, Raba J (2004) Voltammetric determination of salicyclic acid in pharmaceuticals formulations of acetylsalicyclic acid. Talanta 62:247–254

    Article  CAS  Google Scholar 

  110. Diculescu VC, Enache TA, Oliveira PJ, Oliveira-Brett AM (2010) Electrochemical oxidation of sanguinarine and of its oxidation products at a glassy carbon electrode—relevance to intracellular effects. Electroanalysis 22:113–120

    CAS  Google Scholar 

  111. Altun Y, Dogan B, Uslu B, Ozkan SA (2009) Anodic behavior of sertindole and its voltammetric determination in pharmaceuticals and human serum using glassy carbon and boron-doped diamond electrodes. Electrochim Acta 54:1893–1903

    Article  CAS  Google Scholar 

  112. Ozkan SA, Uslu B, Zuman P (2004) Electroanalytical oxidation of sildenafil citrate (Viagra) on carbon electrodes. Anal Chim Acta 501:227–233

    Article  CAS  Google Scholar 

  113. Coruh O, Ozkan SA (2006) Determination of the anti hyperlipidemic simvastatin by various voltammetric techniques in tablets and serum samples. Pharmazie 61:285–290

    CAS  Google Scholar 

  114. Kumar KG, Augustine P, Poduval R, John S (2006) Voltammetric studies of sparfloxacin and application to its determination in pharmaceuticals. Pharmazie 61:291–292

    CAS  Google Scholar 

  115. Ozkan SA, Uslu B (2003) Voltammetric investigation of tamsulosin. Talanta 61:147–156

    Article  CAS  Google Scholar 

  116. Radi A (2004) Preconcentration and differential pulse voltammetry of tegaserod at a glassy carbon electrode. Anal Lett 37:1103–1113

    Article  CAS  Google Scholar 

  117. Yılmaz N, Ozkan SA, Uslu B, Senturk Z, Biryol I (1998) Determination of terbutaline based on oxidation by voltammetry. J Pharm Biomed Anal 17:349–355

    Article  Google Scholar 

  118. Oliveira SCB, Vivan M, Oliveira-Brett AM (2008) Electrochemical behavior of thalidomide at a glassy carbon electrode. Electroanalysis 20:429–2434

    Article  CAS  Google Scholar 

  119. Oliveira SCB, Chiorcea-Paquim AM, Ribeiro SM, Melo ATP, Vivan M, Oliveira-Brett AM (2009) In situ electrochemical and AFM study of thalidomide–DNA interaction. Bioelectrochemistry 76:201–207

    Article  CAS  Google Scholar 

  120. Ozkan SA (1997) Voltammetric determination of tinidazole in tablets. Analusis 25:130–131

    CAS  Google Scholar 

  121. Garrido EMPJ, Garrido JMPJ, Borges F, Delerue-Matos C (2003) Development of electrochemical methods for determination of tramadol—analytical application to pharmaceutical dosage forms. J Pharm Biomed Anal 32:975–981

    Article  CAS  Google Scholar 

  122. Adhoum N, Monser L (2005) Determination of trimebutine in pharmaceuticals by differential pulse voltammetry at a glassy carbon electrode. J Pharm Biomed Anal 38:619–623

    Article  CAS  Google Scholar 

  123. Ghoneim MM, Khashaba PY, Beltagi AM (2002) Determination of trimetazidine HCl by adsorptive stripping square wave voltammetry at a glassy carbon electrode. J Pharm Biomed Anal 27:235–241

    Article  CAS  Google Scholar 

  124. Boutakhrit K, Quarin G, Ozkan SA, Kauffmann J-M (1996) Determination of tin(II) in pharmaceuticals by amperometric oxidation after complexation with tropolone. Electroanalysis 8:89–794

    Article  Google Scholar 

  125. Uslu B, Ozkan SA, Senturk Z (2006) Electrooxidation of the antiviral drug valacyclovir and its square-wave and differential pulse voltammetric determination in pharmaceuticals and human biological fluids. Anal Chim Acta 555:341–347

    Article  CAS  Google Scholar 

  126. Demircan S, Kir S, Ozkan SA (2007) Electroanalytical characterization of verapamil and its voltammetric determination in pharmaceuticals and human serum. Anal Lett 40:1177–1195

    Article  CAS  Google Scholar 

  127. Uslu B, Dogan B, Ozkan SA, Aboul-Enein HY (2005) Electrochemical behavior of vardenafil on glassy carbon electrode: determination in tablets and human serum. Anal Chim Acta 552:127–134

    Article  CAS  Google Scholar 

  128. Thangamutlu R, Kumar SMS, Pillai KC (2007) Direct amperometric determination of l-ascorbic acid (vitamin C) at octacyanomolybdate-doped-poly(4-vinylpyridine) modified electrode in fruit juice and pharmaceuticals. Sens Actuators B 120:745–753

    Article  CAS  Google Scholar 

  129. Radi A, Bechiet G, Wahdan T (2004) Electrochemical study of zolpidem at glassy carbon electrode and its determination in a tablet dosage form by differential pulse voltammetry. Chem Pharm Bull 52:1063–1065

    Article  CAS  Google Scholar 

  130. Sentürk Z, Ozkan SA, Ozkan Y, Aboul-Enein HY (2000) Voltammetric investigation of oxidation of zuclopenthixol and application to its determination in dosage forms and drug dissolution studies. J Pharm Biomed Anal 22:315–323

    Article  Google Scholar 

  131. Kul D, Gumustas M, Uslu B, Ozkan SA (2010) Electroanalytical characteristics of antipsychotic drug ziprasidone and its determination in pharmaceuticals and serum samples on solid electrodes. Talanta 82:286–295

    Article  CAS  Google Scholar 

  132. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2004) Electrochemical analysis of opiates—an overview. Anal Lett 37:845–858

    Article  CAS  Google Scholar 

  133. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2004) Voltammetric oxidation of drugs of abuse III. Heroine and metabolites. Electroanalysis 16:1497–1502

    Article  CAS  Google Scholar 

  134. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2004) Voltammetric oxidation of drugs of abuse II. Codeine and metabolites. Electroanalysis 16:1427–1433

    Article  CAS  Google Scholar 

  135. Garrido JMPJ, Delerue-Matos C, Borges F, Macedo TRA, Oliveira-Brett AM (2004) Voltammetric oxidation of drugs of abuse I. Morphine and metabolites. Electroanalysis 16:1419–1426

    Article  CAS  Google Scholar 

  136. Oliveira-Brett AM, Ghica M-E (2003) Electrochemical oxidation of quercetin. Electroanalysis 15:1745–1750

    Article  CAS  Google Scholar 

  137. Janeiro P, Oliveira-Brett AM (2004) Catechin electrochemical oxidation mechanisms. Anal Chim Acta 518:109–115

    Article  CAS  Google Scholar 

  138. Janeiro P, Oliveira-Brett AM (2005) Solid state electrochemical oxidation mechanism of morin in aqueous media. Electroanalysis 17:733–738

    Article  CAS  Google Scholar 

  139. Ghica M-E, Oliveira-Brett AM (2005) Electrochemical oxidation of rutin. Electroanalysis 17:313–318

    Article  CAS  Google Scholar 

  140. Corduneanu O, Janeiro P, Oliveira-Brett AM (2006) On the electrochemical oxidation of resveratrol. Electroanalysis 18:757–762

    Article  CAS  Google Scholar 

  141. Janeiro P, Corduneanu O, Oliveira-Brett AM (2005) Chrysin and (±)-taxifolin electrochemical oxidation mechanisms. Electroanalysis 38:1059–1064

    Article  CAS  Google Scholar 

  142. Ozkan SA, Uslu B, Aboul-Enein HY (2003) Analysis of pharmaceuticals and biological fluids using modern electroanalytical techniques. Crit Rev Anal Chem 33:155–181

    Article  Google Scholar 

  143. Ozkan SA (2007) LC with electrochemical detection. Recent application to pharmaceuticals and biological fluids. Chromatographia 66:S3–S13

    Article  CAS  Google Scholar 

  144. Uslu B, Ozkan SA (2007) Solid electrodes in electroanalytical chemistry: present applications and prospects for high throughput screening of drug compounds. Comb Chem High T Scr 10:495–513

    CAS  Google Scholar 

  145. Uslu B, Ozkan SA (2007) Electroanalytical application of carbon based electrodes to the pharmaceuticals. Anal Lett 40:817–853

    Article  CAS  Google Scholar 

  146. Ozkan SA (2009) Principles and techniques of electroanalytical stripping methods for pharmaceutical active compounds in dosage forms and biological samples. Curr Pharm Anal 5:127–143

    Article  CAS  Google Scholar 

  147. Swain GM (2004) Electroanalytical applications of diamond electrodes. In: Nebel CE, Ristein J (eds) Semiconductors and semimetals: thin-film diamond II. Elsevier, San Diego, pp 121–145

    Chapter  Google Scholar 

  148. Sarada BV et al (2005) Electroanalytical applications of highly boron-doped diamond electrode. In: Fujishima A et al (eds) Diamond electrochemistry. Elsevier, Tokyo, pp 261–286

    Chapter  Google Scholar 

  149. Enache TA, Chiorcea-Paquim A-M, Fatibello-Filho O et al (2009) Hydroxyl radicals electrochemically generated in situ on a boron-doped diamond electrode. Electrochem Commun 11:1342–1345

    Article  CAS  Google Scholar 

  150. Suffredini HB, Pedrosa VA, Codognoto L et al (2004) Enhanced electrochemical response of boron-doped diamond electrodes brought on by a cathodic surface pre-treatment. Electrochim Acta 49:4021–4026

    Article  CAS  Google Scholar 

  151. Oliveira SCB, Oliveira-Brett AM (2010) Voltammetric and electrochemical impedance spectroscopy characterization of a cathodic and anodic pre-treated boron doped diamond electrode. Electrochim Acta 55:4599–4605

    Article  CAS  Google Scholar 

  152. Jolley S, Koppang M, Jackson T, Swain GM (1997) Flow injection analysis with diamond thin-film detectors. Anal Chem 69:4099–4107

    Article  CAS  Google Scholar 

  153. Codognoto L, Machado SAS, Avaca LA (2002) Square wave voltammetry on boron-doped diamond electrodes for analytical determination. Diam Relat Mater 11:1670–1675

    Article  CAS  Google Scholar 

  154. Sartori ER, Medeiros RA, Rocha-Filho RC, Fatibello-Filho O (2009) Square-wave voltammetric determination of acetylsalicylic acid in pharmaceutical formulations using a boron-doped diamond electrode without the need of previous alkaline hydrolysis step. J Braz Chem Soc 20:360–366

    Article  CAS  Google Scholar 

  155. Lourenção BC, Medeiros RA, Rocha-Filho RC, Fatibello-Filho O (2010) Simultaneous differential pulse voltammetric determination of ascorbic acid and caffeine in pharmaceutical formulations using a boron-doped diamond electrode. Electroanalysis 22:1717–1723

    Article  CAS  Google Scholar 

  156. Lourenção BC, Medeiros RA, Rocha-Filho RC, Mazo LH, Fatibello-Filho O (2009) Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode. Talanta 78:748–752

    Article  CAS  Google Scholar 

  157. Enache TA, Fatibello-Filho O, Oliveira-Brett AM (2010) Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes. Comb Chem High T Scr 13:569–577

    CAS  Google Scholar 

  158. Santos KD, Braga OC, Vieira IC, Spinelli A (2010) Electroanalytical determination of estriol hormone using a boron-doped diamond electrode. Talanta 80:1999–2006

    Article  CAS  Google Scholar 

  159. Oliveira RTS, Salazar-Banda GR, Ferreira VS, Oliveira SC, Avaca LA (2007) Electroanalytical determination of lidocaine in pharmaceuticals preparations using boron-doped diamond electrodes. Electroanalysis 19:1189–1194

    Article  CAS  Google Scholar 

  160. Sartori ER, Medeiros RA, Rocha-Filho RC, Fatibello-Filho O (2010) Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode. Talanta 81:1418–1424

    Article  CAS  Google Scholar 

  161. Sartori ER, Batista EF, Rocha-Filho RC, Fatibello-Filho O (2010) Differential pulse voltammetric determination of sildenafil citrate (Viagra) in pharmaceutical formulations using a boron-doped diamond electrode. Anal Lett 43:1046–1054

    Article  CAS  Google Scholar 

  162. Andrade LS, Rocha-Filho RC, Cass QB, Fatibello-Filho O (2009) Simultaneous differential pulse voltammetric determination of sulfamethoxazole and trimethoprim on a boron doped diamond electrode. Electroanalysis 21:1475–1480

    Article  CAS  Google Scholar 

  163. Souza CD, Braga OC, Vieira IC, Spinelli A (2008) Electroanalytical determination of sulfadiazine and sulfamethoxazole in pharmaceuticals using a boron-doped diamond electrode. Sens Actuators B 135:66–73

    Article  CAS  Google Scholar 

  164. Salazar-Banda GR, Andrade LS, Nascente PAP, Pizani PS, Rocha SC, Avaca LA (2006) On the changing electrochemical behaviour of boron-doped diamond surfaces with time after cathodic pre-treatments. Electrochim Acta 51:4612–4619

    Article  CAS  Google Scholar 

  165. Delahay P (1954) New instrumental methods in electrochemistry. Interscience, New York

    Google Scholar 

  166. Adams RN (1969) Electrochemistry at solid electrodes. Marcel Dekker, New York

    Google Scholar 

  167. McCreery RL, Cline KK (1996) Carbon electrodes. In: Kissinger PT, Heineman WR (eds) Laboratory techniques in electroanalytical chemistry, 2nd edn. Marcel Dekker, New York, pp 293–330, Ch. 10

    Google Scholar 

  168. Kinoshita K (1988) Carbon: electrochemical and physicochemical properties. Wiley, New York

    Google Scholar 

  169. Adams RN (1958) Carbon paste electrodes. Anal Chem 30:1576

    Article  CAS  Google Scholar 

  170. Tallman DE, Petersen SL (1990) Composite electrodes for electroanalysis—principles and applications. Electroanalysis 2:499–510

    Article  CAS  Google Scholar 

  171. Adams RN (1963) Carbon paste electrodes. Rev Polarog 11:71–78

    Article  CAS  Google Scholar 

  172. Kalcher K, Kauffmann JM, Wang J, Svancara I, Vytras K, Neuhold C, Yang Z (1995) Sensors based on carbon-paste in electrochemical analysis—a review with particular emphasis on the period 1990–1993. Electroanalysis 7:5–22

    Article  CAS  Google Scholar 

  173. Stulikova M, Stulík K (1974) Utilization of hydrocarbon materials in electroanalytical chemistry. Chem Listy 68:800–835

    CAS  Google Scholar 

  174. Stulik K, Pacáková V (1981) Electrochemical detection techniques in high-performance liquid-chromatography. J Electroanal Chem 129:1–24

    Article  CAS  Google Scholar 

  175. Wang J (1990) Modified electrodes for electrochemical detection in flowing streams. Anal Chim Acta 234:41–48

    Article  CAS  Google Scholar 

  176. Patriarche GJ, Viré JC (1987) Applications of polarography and voltammetry in analysis for drugs. Anal Chim Acta 196:193–204

    Article  CAS  Google Scholar 

  177. Kalcher K (1990) Chemically modified carbon paste electrodes in voltammetric analysis. Electroanalysis 2:419–433

    Article  CAS  Google Scholar 

  178. Ulakhovich NA, Medyantseva EP, Budnikov GK (1993) Carbon paste electrodes as chemical sensors in voltammetric analysis. Zh Anal Khim 48:980–998

    CAS  Google Scholar 

  179. Kalcher K, Cai X, Kölbl G, Svancara I, Vytras K (1994) New trends in voltammetric analysis: modified carbon paste electrodes. Sb Ved Pr Vys Sk Chem Technol Pardubice 57:5–27

    Google Scholar 

  180. Gorton L (1995) Carbon-paste electrodes modified with enzymes, tissues, and cells. Electroanalysis 7:23–45

    Article  CAS  Google Scholar 

  181. Crespilho FN, Rezende MOO (2004) Carbon paste electrodes modified with humic acids: study and determination of metals in aqueous solution. Quím Nova 27:964–969

    Article  CAS  Google Scholar 

  182. Svancara I, Vytras K, Kalcher K, Walcarius A, Wang J (2009) Carbon paste electrodes in facts, numbers, and notes: a review on the occasion of the 50-years jubilee of carbon paste in electrochemistry and electroanalysis. Electroanalysis 21:7–28

    Article  CAS  Google Scholar 

  183. Svancara I, Walcarius A, Kalcher K, Vytras K (2009) Carbon paste electrodes in the new millennium. Cent Eur J Chem 7:598–656

    Article  CAS  Google Scholar 

  184. Céspedes F, Martinez-Fabregas E, Alegret S (1996) New materials for electrochemical sensing I. Rigid conducting composites. Trends Anal Chem 15:296–304

    Article  Google Scholar 

  185. Alegret S (1996) Rigid carbon—polymer biocomposites for electrochemical sensing—a review. Analyst 121:1751–1758

    Article  CAS  Google Scholar 

  186. Pividori MI, Alegret S (2005) Electrochemical genosensing based on rigid carbon composites. A review. Anal Lett 38:2541–2565

    Article  CAS  Google Scholar 

  187. Wang YR, Hu P, Liang QL, Luo GA, Wang YM (2008) Application of carbon nanotube modified electrode in bioelectroanalysis. Chin J Anal Chem 36:1011–1016

    Article  CAS  Google Scholar 

  188. Dumitrescu I, Unwin PR, Macpherson JV (2009) Electrochemistry at carbon nanotubes: perspective and issues. Chem Commun 45:6886–6901

    Article  CAS  Google Scholar 

  189. Ahammad AJS, Lee JJ, Rahman MA (2009) Electrochemical sensors based on carbon nanotubes. Sensors 9:2289–2319

    Article  CAS  Google Scholar 

  190. Wei D, Ivaska A (2008) Applications of ionic liquids in electrochemical sensors. Anal Chim Acta 607:126–135

    Article  CAS  Google Scholar 

  191. Navratil T, Barek J (2009) Analytical applications of composite solid electrodes. Crit Rev Anal Chem 39:131–147

    Article  CAS  Google Scholar 

  192. Cervini P (2006) Aplicação de eletrodos compósitos a base de poliuretana-graphite. 2006, 185f. Tese (Doutorado em Ciências—Química Analítica)—Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-12042007-095708/. Accessed 5 Sep 2011

  193. Trijueque J, García-Jareño JJ, Navarro-Laboulais J, Sanmantías A, Vicente F (1999) Ohmic drop of Prussian-blue/graphite+epoxy electrodes. Electrochim Acta 45:789–795

    Article  CAS  Google Scholar 

  194. Navarro-Laboulais J, Trijueque J, Vicente F, Scholl H (1994) Voltammetric determination of optimal conductive load proportion in graphite–epoxy composite electrodes. J Electroanal Chem 379:159–163

    Article  Google Scholar 

  195. Albertús F, Llerena A, Alpízar J, Cerda V, Luque M, Rios A, Valcárcel M (1997) A PVC–graphite composite electrode for electroanalytical use. Anal Chim Acta 355:23–32

    Article  Google Scholar 

  196. Wang J, Golden T, Varughese K, El-Rayes I (1989) Polishable and robust modified graphite epoxy electrodes. Anal Chem 61:508–512

    Article  CAS  Google Scholar 

  197. Anderson J, Tallman DE, Chesney DJ, Anderson JL (1978) Fabrication and characterization of a Kel-F–graphite composition electrode for a general voltammetric applications. Anal Chem 50:1051–1056

    Article  CAS  Google Scholar 

  198. Elvin PJ, Krivis AF (1958) Voltammetric studies with the graphite indicating electrode. Anal Chem 30:1645–1648

    Article  Google Scholar 

  199. Gun G, Tsionsky M, Lev O (1994) Voltammetric studies of composite ceramic carbon working electrodes. Anal Chim Acta 294:261–270

    Article  CAS  Google Scholar 

  200. Pungor E, Szepesváry E (1968) Voltammetric studies with silicone rubber-based graphite electrodes. Anal Chim Acta 43:289–296

    Article  CAS  Google Scholar 

  201. Mendes RK, Claro-Neto S, Cavalheiro ETG (2002) Evaluation of a new rigid carbon–castor oil polyurethane composite as an electrode material. Talanta 57:909–917

    Article  CAS  Google Scholar 

  202. Cesarino I, Marino G, Cavalheiro ETG (2010) A novel graphite–polyurethane composite electrode modified with thiol-organofunctionalized silica for the determination of copper ions in ethanol fuel. Fuel 89:1883–1888

    Article  CAS  Google Scholar 

  203. de-Toledo RA, Santos MC, Cavalheiro ETG, Mazo LH (2005) Determination of dopamine in synthetic cerobrospinal fluid by SWV with graphite polyurethane composite electrode. Anal Bioanal Chem 381:1161–1166

    Article  CAS  Google Scholar 

  204. de-Toledo RA, Santos MC, Honório KM, da-Silva ABF, Cavalheiro ETG, Mazo LH (2006) Use of graphite polyurethane composite electrode for imipramine oxidation—mechanism proposal and electroanalytical determination. Anal Lett 39:507–520

    Article  CAS  Google Scholar 

  205. Malagutti AR, Zuin VG, Cavalheiro ETG, Mazo LH (2006) Determination of rutin in green tea infusions using square-wave voltammetry with a rigid carbon–polyurethane composite electrode. Electroanalysis 18:1028–1034

    Article  CAS  Google Scholar 

  206. Cervini P, Ramos LA, Cavalheiro ETG (2007) Determination of atenolol at a graphite–polyurethane composite electrode. Talanta 72:206–209

    Article  CAS  Google Scholar 

  207. Cervini P, Cavalheiro ETG (2008) Graphite-polyurethane composite electrode as an amperometric flow detector in the determination of atenolol. Anal Lett 41:1867–1877

    Article  CAS  Google Scholar 

  208. Semaan FS, Pinto EM, Cavalheiro ETG, Brett CMA (2008) A graphite–polyurethane composite electrode for the analysis of furosemide. Electroanalysis 20:2287–2293

    Article  CAS  Google Scholar 

  209. Semaan FS, Cavalheiro ETG, Brett CMA (2009) Electrochemical behavior of verapamil at graphite–polyurethane composite electrodes: determination of release profiles in pharmaceutical samples. Anal Lett 42:1119–1135

    Article  CAS  Google Scholar 

  210. Cervini P, Cavalheiro ETG (2009) Evaluation of the analytical potentialities of a composite electrode modified with molecularly imprinted polymers. Anal Lett 42:1940–1957

    Article  CAS  Google Scholar 

  211. de-Toledo RA, Santos MC, Suffredini HB, Homem-de-Mello P, Honório KM, Mazo LH (2009) DFT and electrochemical studies on nortriptyline oxidation sites. J Mol Model 15:945–952

    Article  CAS  Google Scholar 

  212. Swofford HS, Carman RL (1966) Voltammetric applications of rotating and stationary carbon–epoxy electrodes. Anal Chem 38:966–969

    Article  CAS  Google Scholar 

  213. Calixto CMF, Cervini P, Cavalheiro ETG (2008) Eletrodo compósito à base de graphite-Araldite®: aplicações didáticas. Quím Nova 31:2194–2198

    Article  CAS  Google Scholar 

  214. Wring SA, Hart JP, Birch BJ (1990) Voltammetric behavior of ascorbic-acid at a graphite epoxy composite electrode chemically modified with cobalt phthalocyanine and its amperometric determination in multivitamin preparations. Anal Chim Acta 229:63–70

    Article  CAS  Google Scholar 

  215. Sebkova S, Navratil T, Kopanica M (2005) Graphite composite electrode in voltammetry. Anal Lett 38:1747–1758

    Article  CAS  Google Scholar 

  216. Kiryushov VN, Skvortsova LI, Aleksandrova TP (2007) Voltammetric studies of the activity of an electrode made of a graphite–epoxy composite in redox reactions of ascorbic acid and hydroquinone. J Anal Chem 62:161–167

    Article  CAS  Google Scholar 

  217. Pungor E, Szepesváry E, Havas J (1968) Voltammetric studies on graphite impregnated silicone rubber electrodes. Anal Lett 1:213–220

    Article  CAS  Google Scholar 

  218. Pungor E, Feher Z, Nagy G (1971) Voltammetric determinations of some drugs using silicone rubber-based electrodes. Magy Kem Foly 77:298–302

    CAS  Google Scholar 

  219. Pungor E, Nagy G, Feher Z (1971) Use of silicone rubber-based graphite in flowing media. II. Voltammetric determination of electroactive materials injected into a flowing supporting electrolyte. Magy Kem Foly 77:294–298

    CAS  Google Scholar 

  220. Feher Z, Nagy G, Toth K, Pungor E (1974) The use of precipitate based silicone rubber ion-selective electrodes and silicone rubber based graphite voltammetric electrodes in continuous analysis. A review. Analyst 99:699–708

    Article  CAS  Google Scholar 

  221. Pungor E, Feher Z, Nagy G (1975) The voltammetric application of silicone rubber based graphite electrodes with special regard to flowing systems. Pure Appl Chem 44:595–612

    Article  CAS  Google Scholar 

  222. Niegreisz Z, Horvai G, Toth K, Pungor E (1986) Silicone rubber wall-jet electrode in hydrodynamic voltammetry. Symp Biol Hung 31:83–95

    CAS  Google Scholar 

  223. Santos SX, Mazo LH, Cavalheiro ETG (2008) The use of a graphite–silicone rubber composite electrode in the determination of rutin in pharmaceutical formulation. J Braz Chem Soc 19:1600–1606

    Article  Google Scholar 

  224. Santos SX, Cavalheiro ETG (2011) The potentialities of using a graphite–silicone rubber composite electrode in the determination of propranolol. Anal Lett 44:850–862

    Article  CAS  Google Scholar 

  225. Catarino RIL, Garcia MBQ, Lapa RAS, Lima JLFC, Barrado E (2002) Sequential determination of salicylic and acetylsalicylic acids by amperometric multisite detection flow injection analysis. J AOAC Int 85:1253–1259

    CAS  Google Scholar 

  226. Freitas KHG, Medeiros RA, Fatibello-Filho O (2009) Voltammetric determination of rutin using a carbon composite electrode modified with copper(II)–resin. Anal Lett 42:881–897

    Article  CAS  Google Scholar 

  227. Cano M, Palenzuela B, Rodriguez-Amaro R (2006) A PVC/TTF–TCNQ composite electrode for use as a detector in flow injection analysis. Electroanalysis 18:1727–1729

    Article  CAS  Google Scholar 

  228. Blanco-Lopez MC, Fernandez-Llano L, Lobo-Castanon MJ, Miranda-Ordieres AJ, Tunon-Blanco P (2004) Voltammetry of diclofenac at graphite, carbon composites, and molecularly imprinted polymer-composite electrodes. Anal Lett 37:915–927

    Article  CAS  Google Scholar 

  229. Aguilar-Sanchez R, Ahuatl-Garcia F, Davila-Jimenez MM, Elizalde-González MP, Guevara-Villa MR (2005) Chromatographic and electrochemical determination of quercetin and kaempferol in phytopharmaceuticals. J Pharm Biomed Anal 38:239–249

    Article  CAS  Google Scholar 

  230. Manea F, Radovan C, Corb I, Pop A, Burtica G, Malchev P, Picken S, Schoonman J (2007) Electrochemical oxidation and determination of oxalic acid at an exfoliated graphite–polystyrene composite electrode. Sensors 7:615–627

    Article  CAS  Google Scholar 

  231. Barsan MM, Pinto EM, Florescu M, Brett CMA (2009) Development and characterization of a new conducting carbon composite electrode. Anal Chim Acta 635:71–78

    Article  CAS  Google Scholar 

  232. Xie XF, Zhou DZ, Zheng XJ, Huang WS, Wu KB (2009) Electrochemical sensing of rutin using an MCM-41 modified electrode. Anal Lett 42:678–688

    Article  CAS  Google Scholar 

  233. Qi B, Du Y, Yang XR (2008) Determination of benzhexol and procyclidine using an electrochemiluminescence-based sensor constructed by a screen-print technique. Microchim Acta 162:211–217

    Article  CAS  Google Scholar 

  234. Prasad BB, Tiwari MP, Madhuri R, Sharma PS (2010) Development of a highly sensitive and selective hyphenated technique (molecularly imprinted micro-solid phase extraction fiber-molecularly imprinted polymer fiber sensor) for ultratrace analysis of folic acid. Anal Chim Acta 662:14–22

    Article  CAS  Google Scholar 

  235. Prasad BB, Madhuri R, Tiwari MP, Sharma PS (2010) Enantioselective recognition of D- and L-tryptophan by imprinted polymer-carbon composite fiber sensor. Talanta 81:187–196

    Article  CAS  Google Scholar 

  236. Rodriguez MC, Rivas GA (2002) Glassy carbon paste electrodes modified with polyphenol oxidase. Analytical applications. Anal Chim Acta 459:43–51

    Article  CAS  Google Scholar 

  237. dos-Santos SX, Cavalheiro ETG, Brett CMA (2010) Analytical potentialities of carbon nanotube/silicone rubber composite electrodes: the determination of propranolol. Electroanalysis 22:2776–2783

    Article  CAS  Google Scholar 

  238. Shahrokhian S, Asafian E (2010) Simultaneous voltammetric determination of ascorbic acid, acetaminophen and isoniazid using thionine immobilized multi-walled carbon nanotube modified carbon paste electrode. Electrochim Acta 55:666–672

    Article  CAS  Google Scholar 

  239. Joseph R, Kumar KG (2009) Electrochemical reduction and voltammetric determination of metronidazole benzoate at modified carbon paste electrode. Anal Lett 42:2309–2321

    Article  CAS  Google Scholar 

  240. Batista IV, Lanza MRV, Dias ILT, Tanaka SMCN, Tanaka AA, Sotomayor MDPT (2008) Electrochemical sensor highly selective for estradiol valerate determination based on a modified carbon paste with iron tetrapyridinoporphyrazine. Analyst 133:1692–1699

    Article  CAS  Google Scholar 

  241. Stefan-van Staden RI, Bokretsion RG (2006) Simultaneous determination of creatine and creatinine using monocrystalline diamond paste-based amperometric biosensors. Anal Lett 39:2227–2233

    Article  CAS  Google Scholar 

  242. Moccelini SK, Franzoi AC, Vieira IC, Dupont J, Scheeren CW (2011) A novel support for laccase immobilization: cellulose acetate modified with ionic liquid and application in biosensor for methyldopa detection. Biosens Bioelectron 26:3549–3554

    Article  CAS  Google Scholar 

  243. Agüi L, Manso J, Yáñez-Sedeño P, Pingarrón JM (2004) Colloidal-gold cysteamine-modified carbon paste electrodes as suitable electrode materials for the electrochemical determination of sulphur-containing compounds. Application to the determination of methionine. Talanta 64:1041–1047

    Article  CAS  Google Scholar 

  244. Pauliukaite R, Ghica ME, Fatibello-Filho O, Brett CMA (2010) Graphite–epoxy electrodes modified with functionalised carbon nanotubes and chitosan for the rapid electrochemical determination of dipyrone. Comb Chem High T Scr 13:590–598

    CAS  Google Scholar 

  245. Wei JA, He JB, Cao SQ, Zhu YW, Wang Y, Hang GP (2010) Enhanced sensing of ascorbic acid, dopamine and serotonin at solid carbon paste electrode with a nonionic polymer film. Talanta 83:190–196

    Article  CAS  Google Scholar 

  246. Radi A (2010) Recent updates of chemically modified electrodes in pharmaceutical analysis. Comb Chem High T Scr 13:728–752

    CAS  Google Scholar 

  247. Renedo OD, Alonso-Lomillo MA, Martinez MJA (2007) Recent developments in the field of screen-printed electrodes and their related applications. Talanta 73:202–219

    Article  CAS  Google Scholar 

  248. Bergamini MF, Santos DP, Zanoni MVB (2010) Determination of isoniazid in human urine using screen-printed carbon electrode modified with poly-L-histidine. Bioelectrochemistry 77:133–138

    Article  CAS  Google Scholar 

  249. Su W, Cheng SH (2010) Electrochemical oxidation and sensitive determination of acetaminophen in pharmaceuticals at poly(3,4-ethylenedioxythiophene)-modified screen-printed electrodes. Electroanalysis 22:707–714

    Article  CAS  Google Scholar 

  250. Honeychurch KC, Gilbert L, Hart JP (2010) Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine-modified screen-printed carbon electrode and its application in pharmaceutical and food analysis. Anal Bioanal Chem 396:3103–3111

    Article  CAS  Google Scholar 

  251. Dominguez-Renedo O, Calvo MEB, Alonso-Lomillo MA (2010) Oxcarbazepine analysis by adsorptive stripping voltammetry using silver nanoparticle-modified carbon screen-printed electrodes. Sens Lett 8:268–272

    Article  CAS  Google Scholar 

  252. Wu SH, Nie FH, Chen QZ, Sun JJ (2011) Highly sensitive detection of silybin based on adsorptive stripping analysis at single-sided heated screen-printed carbon electrodes modified with multi-walled carbon nanotubes with direct current heating. Anal Chim Acta 687:43–49

    Article  CAS  Google Scholar 

  253. Jacobs CB, Peairs MJ, Venton BJ (2010) Carbon nanotube based electrochemical sensors for biomolecules. Anal Chim Acta 662:105–127

    Article  CAS  Google Scholar 

  254. Carvalho RC, Gouveia-Caridade C, Brett CMA (2010) Glassy carbon electrodes modified by multiwalled carbon nanotubes and poly(neutral red). A comparative study of different brands and application to electrocatalytic ascorbate determination. Anal Bioanal Chem 398:1675–1685

    Article  CAS  Google Scholar 

  255. Sanghavi BJ, Srivastava AK (2011) Adsorptive stripping differential pulse voltammetric determination of venlafaxine and desvenlafaxine employing Nafion–carbon nanotube composite glassy carbon electrode. Electrochim Acta 56:4188–4196

    Article  CAS  Google Scholar 

  256. Xu XL, Huang F, Zhou GL, Zhang S, Kong JL (2010) A novel electrochemical sensor for probing doxepin created on a glassy carbon electrode modified with poly(4-amino-benzoic acid)/multi-walled carbon nanotubes composite film. Sensing 10:8398–8410

    Article  CAS  Google Scholar 

  257. Wang CY, Guan J, Qu QS, Yang GJ, Hu XY (2007) Voltammetric determination of sinomenine in biological fluid using a glassy carbon electrode modified by a composite film of polycysteic acid and carbon nanotubes. Comb Chem High T Scr 10:595–603

    CAS  Google Scholar 

  258. Babaei A, Afrasiabi M, Babazadeh M (2010) A glassy carbon electrode modified with multiwalled carbon nanotube/chitosan composite as a new sensor for simultaneous determination of acetaminophen and mefenamic acid in pharmaceutical preparations and biological samples. Electroanalysis 22:1743–1749

    Article  CAS  Google Scholar 

  259. Pauliukaite R, Ghica ME, Fatibello-Filho O, Brett CMA (2009) A comparative study of different crosslinking agents for the immobilization of functionalized carbon nanotubes within a chitosan film supported on a graphite–epoxy composite electrode. Anal Chem 81:5364–5372

    Article  CAS  Google Scholar 

  260. Habibi B, Jahanbakhshi M, Pournaghiazar MH (2011) Electrochemical oxidation and nanomolar detection of acetaminophen at a carbon-ceramic electrode modified by carbon nanotubes: a comparison between multi walled and single walled carbon nanotubes. Microchim Acta 172:147–154

    Article  CAS  Google Scholar 

  261. Ghalkhani M, Shahrokhian S, Ghorbani-Bidkorbeh F (2009) Voltammetric studies of sumatriptan on the surface of pyrolytic graphite electrode modified with multi-walled carbon nanotubes decorated with silver nanoparticles. Talanta 80:31–38

    Article  CAS  Google Scholar 

  262. Shahrokian S, Ghalkhani M, Adeli M, Amini MK (2009) Multi-walled carbon nanotubes with immobilised cobalt nanoparticle for modification of glassy carbon electrode: application to sensitive voltammetric determination of thioridazine. Biosens Bioelectron 24:3235–3241

    Article  CAS  Google Scholar 

  263. Ji YL, Wang GF, Zhang CH, Fang B (2011) Electrocatalysis of puerarin on a nano-CeO2/MWCNTs composite modified electrode and its determination in pharmaceutical preparations. Chinese J Chem 29:1017–1023

    Article  CAS  Google Scholar 

  264. Lu TL, Tsai YC (2011) Sensitive electrochemical determination of acetaminophen in pharmaceutical formulations at multiwalled carbon nanotube-alumina-coated silica nanocomposite modified electrode. Sensor Actuat B-Chem 153:439–444

    Article  CAS  Google Scholar 

  265. Kul D, Brett CMA (2011) Electroanalytical characterisation of dopa decarboxylase inhibitors carbidopa and benserazide on multiwalled carbon nanotube and poly(Nile blue A) modified glassy carbon electrodes. Inter J Electrochem ID185684:1–7

    Google Scholar 

  266. Pacios M, del Valle M, Bartroli J, Esplandiu MJ (2008) Electrochemical behavior of rigid carbon nanotube composite electrodes. J Electroanal Chem 619–620:117–124

    Google Scholar 

  267. Heli H, Majdi S, Jabbari A, Sattarahmady N, Moosavi-Movahedi AA (2010) Electrooxidation of dextromethorphan on a carbon nanotube–carbon microparticle–ionic liquid composite: applied to determination in pharmaceutical forms. J Solid State Electrochem 14:1515–1523

    Article  CAS  Google Scholar 

  268. Goyal RN, Bachheti N, Tyagi A, Pandey AK (2007) Differential pulse voltammetric determination of methylprednisolone in pharmaceuticals and human biological fluids. Anal Chim Acta 605:34–40

    CAS  Google Scholar 

  269. Jain R, Rather JA, Dwivedi A, Vikas DA (2010) Highly sensitive and selective voltammetric sensor fullerene modified glassy carbon electrode for determination of cefitizoxime in solubilized system. Electroanalysis 22:2600–2606

    Article  CAS  Google Scholar 

  270. Goyal RN, Gupta VK, Chatterjee S (2009) Fullerene-C-60-modified edge plane pyrolytic graphite electrode for the determination of dexamethasone in pharmaceutical formulations and human biological fluids. Biosens Bioelectron 24:1649–1654

    Article  CAS  Google Scholar 

  271. Goyal RN, Gupta VK, Chatterjee S (2009) A sensitive voltammetric sensor for determination of synthetic corticosteroid triamcinolone, abused for doping. Biosens Bioelectron 24:3562–3568

    Article  CAS  Google Scholar 

  272. Goyal RN, Oyama M, Bachheti N, Singh SP (2009) Fullerene C-60 modified gold electrode and nanogold modified indium tin oxide electrode for prednisolone determination. Bioelectrochemistry 74:272–277

    Article  CAS  Google Scholar 

  273. Goyal RN, Gupta VK, Bachheti N, Sharma R (2008) Electrochemical sensor for the determination of dopamine in presence of high concentration of ascorbic acid using a fullerene-C-60 coated gold electrode. Electroanalysis 20:757–764

    Article  CAS  Google Scholar 

  274. Salem AEA, Barsoum BN, Saad GR, Izake EL (2002) Potentiometric determination of some 1,4-benzodiazepines in pharmaceutical preparations and biological samples. J Electroanal Chem 536:1–9

    Article  CAS  Google Scholar 

  275. Gupta VK, Singh AK, Gupta B (2007) Development of membrane electrodes for selective determination of some antiepileptic drugs in pharmaceuticals, plasma and urine. Anal Bioanal Chem 389:2019–2028

    Article  CAS  Google Scholar 

  276. Gamal AE, Mostafa GAE, Al-Majed A (2008) Characteristics of new composite- and classical potentiometric sensors for the determination of pioglitazone in some pharmaceutical formulations. J Pharm Biomed Anal 48:57–61

    Article  CAS  Google Scholar 

  277. Mohamed GG, Ali TA, El-Shahat MF, Al-Sabagh AM, Migahed MA, Khaled E (2010) Potentiometric determination of cetylpyridinium chloride using a new type of screen-printed ion selective electrodes. Anal Chim Acta 673:79–87

    Article  CAS  Google Scholar 

  278. Mohamed GG, El-Shahat MF, Al-Sabagh AM, Migahed MA, Ali TA (2011) Septonex-tetraphenylborate screen-printed ion selective electrode for the potentiometric determination of Septonex in pharmaceutical preparations. Analyst 136:1488–1495

    Article  CAS  Google Scholar 

  279. Ensafi AA, Allafchian AR (2008) Novel and selective potentiometric membrane sensor for amiloride determination in pharmaceutical compounds and urine. J Pharm Biomed Anal 47:802–806

    Article  CAS  Google Scholar 

  280. El-Naby EH (2008) Polymeric membrane sensors for the selective determination of dextromethorphan in pharmaceutical preparations. Anal Sci 24:1409–1414

    Article  CAS  Google Scholar 

  281. Heba M, Ramadan N, El-Laithy M (2008) Polymeric matrix membrane sensors for stability-indicating potentiometric determination of oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs. J AOAC Inter 91:1318–1330

    CAS  Google Scholar 

  282. Badawy WA, El-Ries MA, Mahdi IM (2009) Carbon paste and PVC membrane electrodes as sensitive sensors for the determination of antidiabetic drugs for type 2 diabetic patients. Anal Sci 25:1431–1436

    Article  CAS  Google Scholar 

  283. Stefan-van Staden RI, Nhlapo NS, van Staden JF, Aboul-Enein HY (2009) Enantioanalysis of S-ketoprofen using enantioselective, potentiometric membrane electrodes. Anal Lett 42:764–774

    Article  CAS  Google Scholar 

  284. Staden RLSV, Lal B, Holo L (2007) Enantioselective potentiometric membrane electrodes based on C-60 fullerene and its derivatives for the assay of (L)-histidine. Talanta 71:1434–1437

    Article  CAS  Google Scholar 

  285. Stefan-van Staden RI (2010) Enantioanalysis of S-ibuprofen using [5–6] fullerene-C-70 and diethyl (1,2-methanofullerene C-70)-71-71-dicarboxylate. Anal Meth 2:37–40

    Article  CAS  Google Scholar 

  286. Stefan-van Staden RI (2010) Enantioanalysis of S-deprenyl using enantioselective, potentiometric membrane electrodes based on C-60 derivatives. Electrochim Acta 55:1772–1777

    Article  CAS  Google Scholar 

  287. Saber AL (2010) Novel potentiometric sensors for determination of melatonin and oxomemazine in biological samples and in pharmaceutical formulations. Electroanalysis 22:2997–3002

    Article  CAS  Google Scholar 

  288. Moreira FTP, Freitas VAP, Sales MGF (2011) Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction. Microchim Acta 172:15–23

    Article  CAS  Google Scholar 

  289. Alonso-Lomillo MA, Yardimci C, Dominguez-Renedo O, Arcos-Martinez MJ (2009) CYP450 2B4 covalently attached to carbon and gold screen printed electrodes by diazonium salt and thiols monolayers. Anal Chim Acta 633:51–56

    Article  CAS  Google Scholar 

  290. Alonso-Lomillo MA, Gonzalo-Ruiz J, Dominguez-Renedo O, Munoz F, Arcos-Martinez MJ (2008) CYP450 biosensors based on gold chips for antiepileptic drugs determination. Biosens Bioelectron 23:1733–1737

    Article  CAS  Google Scholar 

  291. Alonso-Lomillo MA, Dominguez-Renedo O, Matos P, Arcos-Martinez MJ (2009) Electrochemical determination of levetiracetam by screen-printed based biosensors. Bioelectrochemistry 74:306–309

    Article  CAS  Google Scholar 

  292. Alonso-Lomillo MA, Dominguez-Renedo O, Hernandez-Martin A, Arcos-Martinez MJ (2009) Horseradish peroxidase covalent grafting onto screen-printed carbon electrodes for levetiracetam chronoamperometric determination. Anal Biochem 395:86–90

    Article  CAS  Google Scholar 

  293. Sima V, Cristea C, Bodoki E, Dutu G, Sandulescu R (2010) Screen-printed electrodes modified with HRP-zirconium alcoxide film for the development of a biosensor for acetaminophen detection. Cent Eur J Chem 8:1034–1040

    Article  CAS  Google Scholar 

  294. Stefan-van Staden RI, Ozoemena KI (2009) Amperometric immunosensor for the determination of 20,30-dideoxyinosine. Anal Lett 42:758–763

    Article  CAS  Google Scholar 

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Acknowledgments

Financial support from Fundação para a Ciência e Tecnologia and CEMUC-R (Research Unit 285), Portugal, as well as the support from FAPESP, CAPES and CNPq, Brazil, are gratefully acknowledged.

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Authors and Affiliations

  1. Instituto de Química de São Carlos, USP, Av. do Trabalhador San-carlense, 400, CEP 13566-590, São Carlos, São Paulo, Brazil

    Éder Tadeu Gomes Cavalheiro

  2. Departamento de Quimica, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, 3004-535, Coimbra, Portugal

    Christopher M. A. Brett & Ana Maria Oliveira-Brett

  3. Departamento de Química, Universidade Federal de São Carlos, Via Washington Luis, km 235, CEP 13565-905, São Carlos, São Paulo, Brazil

    Orlando Fatibello-Filho

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  1. Éder Tadeu Gomes Cavalheiro
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  2. Christopher M. A. Brett
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  3. Ana Maria Oliveira-Brett
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  4. Orlando Fatibello-Filho
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Correspondence to Orlando Fatibello-Filho.

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Cavalheiro, É.T.G., Brett, C.M.A., Oliveira-Brett, A.M. et al. Bioelectroanalysis of pharmaceutical compounds. Bioanal Rev 4, 31–53 (2012). https://doi.org/10.1007/s12566-012-0027-8

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  • DOI: https://doi.org/10.1007/s12566-012-0027-8

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