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Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals

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Biomedical and Pharmaceutical Applications of Electrochemistry

Part of the book series: Modern Aspects of Electrochemistry ((MAOE,volume 60))

Abstract

This review concerns on recent advances in the application of various modern electrochemical techniques to the analysis of pharmaceuticals and biological samples. It is known that different highly sensitive electrochemical techniques are well established in the analysis of selected drugs. The application and choise of the most prefered electrochemical techniques applied to the analysis is closely related on physicochemical properties of the organic functional groups that comprise any given drug structure, especially on redox properties of the pharmaceuticals and biomolecules in real samples.

This chapter describes the application of the most commonly used voltammetric techniques combined with different chromatographic and spectrophotometric as well as spectroscopic techniques in the different aspects of analysis of the pharmaceuticals. Pharmaceutically active compounds under consideration belong to: chemotherapeutic agents (antibiotics), drugs receptor affecting neurotransmission and enzymes as catalytic receptors, drugs affecting the cardiovascular system, drugs affecting the immune systems and some other drugs. The review predominantly discusses over 100 publications from period between 2006–2015, with special emphasis on the solving of large number of different analytical pharmaceutical problems. By using the appropriate electroanalytical techniques, owing to their high sensitivity, selectivity and simplicity, it is possible to overcome some problems in standard pharmaceutical analysis on the best way. The selected our most important papers and observed papers which treat electrochemical analysis of pharmaceuticals are discussed, as much as possible, in the chronological order of their publication. The new electroanalytical methods for qualitative and quantitative determination of standard substancies and as a content of commecial tablets are offered and discussed in analysis of five macrolide antibiotics, amphetamines, carbamazepine, donepezil, amlodipine, nifedipine, clopidogrel, tamiflu, oxaprozin and some other drugs. Some drugs are analized in human biological samples.

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Acknowledgments

The work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (Grant No. ON172013).

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Authors and Affiliations

  1. ICTM-Institute of Electrochemistry, University of Belgrade, Njegoševa 12, 473, 11000, Belgrade, Serbia

    Milka L. Avramov Ivić

  2. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, P.O. Box 3503, 11001, Belgrade, Serbia

    Slobodan D. Petrović & Dušan Ž. Mijin

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  1. Milka L. Avramov Ivić
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  2. Slobodan D. Petrović
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  3. Dušan Ž. Mijin
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Correspondence to Milka L. Avramov Ivić .

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  1. Elchem Consulting Ltd., Edmonton, Alberta, Canada

    Stojan Djokić

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Ivić, M.L.A., Petrović, S.D., Mijin, D.Ž. (2016). Contribution to the Recent Advances in Electrochemical Analysis of Pharmaceuticals. In: Djokić, S. (eds) Biomedical and Pharmaceutical Applications of Electrochemistry. Modern Aspects of Electrochemistry, vol 60. Springer, Cham. https://doi.org/10.1007/978-3-319-31849-3_2

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