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Myocardial blood flow quantitation in patients with congestive heart failure: head-to-head comparison between rapid-rotating gantry SPECT and CZT SPECT

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Journal of Nuclear Cardiology Aims and scope

Abstract

Purpose

Recently, the feasibility of myocardial blood flow (MBF) quantitation using rapid-rotating gantry (RRG) and cadmium–zinc–telluride (CZT) SPECT cameras has been demonstrated. We compared MBF quantitation using these two camera systems.

Methods

Twenty patients with congestive heart failure (CHF) and 20 patients without CHF (non-CHF) were included. On two consecutive days, dynamic SPECT imaging was performed after a bolus injection of 20 mCi of 99mTc-Sestamibi (MIBI) with RRG-SPECT and list-mode acquisition with CZT-SPECT. All dynamic SPECT images were reconstructed with full physical corrections, corrections for ventricular spillover and partial volume effect, using one-tissue kinetic modeling. Resting MBF converted from K1 was then corrected for MIBI extraction fraction and adjusted for rate-pressure product.

Results

In both patient groups, there was no significant difference between resting MBF values measured with RRG-SPECT and CZT-SPECT systems (P = 0.06, P = 0.2 respectively). For CHF patients, linear regression (LR) was y(RRG) = 1.0412x (CZT) (r = 0.97) with a small systemic difference (Δ = 0.03 mL·min−1·g−1, 95% CI − 0.11 to 0.20) by Bland–Altman analysis. For non-CHF patients, LR was y(RRG) = 1.025x (CZT) (r = 0.89) with also small systemic difference (ΔT= 0.02 mL·min−1·g−1, 95% CI − 0.14 to 0.19) in BA analysis.

Conclusion

Physical corrections along with other image corrections can provide comparable MBF quantitations in both CHF and non-CHF patients, regardless of the type of SPECT systems used.

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Abbreviations

SPECT:

Single photon emission computed tomography

RRG:

Rapid-rotating gantry

CZT:

Cadmium–zinc–telluride

MBF:

Myocardial blood flow

CHF:

Congestive heart failure

MIBI:

99mTc-Sestamibi

ESV:

End-systolic volume

EDV:

End-diastolic volume

FBV:

Fractional blood volume

RPC:

Repeatability coefficient

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Acknowledgements

This article was finalized under the auspices of the “Mentorship at Distance” committee of the Journal of Nuclear Cardiology. The authors gratefully acknowledge the editorial suggestions by Frans J. Th. Wackers, MD, PhD.

Disclosure

BH, Scientific consultant, received support from Sinotaucloud Medical Technologies, Beijing, China. RM, LW, DW, MW, XS and WF declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Author notes

  1. Rongzheng Ma and Lei Wang have contributed equally to this work.

Authors and Affiliations

  1. Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing, 100037, China

    Rongzheng Ma MD, Lei Wang MD, PhD, Dayong Wu MD, Meng Wang MD, Xiaoxin Sun MD & Wei Fang MD

  2. Nuclear Science and Engineering Institute, University of Missouri-Columbia, E2433 Lafferre Hall, Columbia, MO, 65211, USA

    Bailing Hsu PhD

  3. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan

    Bailing Hsu PhD

Authors
  1. Rongzheng Ma MD
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  2. Lei Wang MD, PhD
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  3. Dayong Wu MD
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  4. Meng Wang MD
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  5. Xiaoxin Sun MD
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  6. Bailing Hsu PhD
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  7. Wei Fang MD
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Corresponding authors

Correspondence to Xiaoxin Sun MD, Bailing Hsu PhD or Wei Fang MD.

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Funding This research was supported by a grant from National Natural Science Foundation of China (Grant No.: 81771872).

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Ma, R., Wang, L., Wu, D. et al. Myocardial blood flow quantitation in patients with congestive heart failure: head-to-head comparison between rapid-rotating gantry SPECT and CZT SPECT. J. Nucl. Cardiol. 27, 2287–2302 (2020). https://doi.org/10.1007/s12350-019-01621-2

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