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Assessment of left ventricular ejection fraction with cardiofocal collimators: Comparison between IQ-SPECT, planar equilibrium radionuclide angiography, and cardiac magnetic resonance

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

IQ-SPECT has been shown to significantly reduce acquisition time and administered dose while preserving image quality in myocardial perfusion imaging. Whether IQ-SPECT provides accurate left ventricular ejection fractions (LVEF) with gated blood pool SPECT (GBPS) remains unknown.

Methods

Sixty patients underwent IQ-SPECT GBPS and planar imaging. Among those patients, 11 underwent both cMRI and GBPS. GBPS LVEF, LVEDV, and LVESV were calculated using 2 validated software; QBS (Cedars-Sinai Medical Center, Los Angeles, USA) and MHI (Montreal Heart Institute, Montreal, Canada). LVEF, LVEDV, and LVESV obtained with the different modalities were compared.

Results

Average planar LVEF was 48 ± 11% (mean ± SD), average LVEDV was 177 ± 59 mL (range 63 to 342 mL), and average LVESV was 96 ± 46 mL (range 16 to 234 mL). GBPS LVEF and their correlation coefficient with planar LVEF were 40 ± 12% (r = 0.70) and 44 ± 12% (r = 0.83) with QBS and MHI, respectively. Correlation coefficient between cMRI and planar LVEF was 0.65 and were 0.69 and 0.52 between cMRI and GBPS using QBS and MHI, respectively.

Conclusions

LVEF calculated with GBPS using IQ-SPECT correlates with planar measurements. Correlation is best using the MHI method and variation is independent of LVEDV.

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Abbreviations

GBPS:

Gated blood pool SPECT

ICD:

Implantable cardioverter defibrillator

LEAP:

Low energy all purpose

LEHR:

Low energy high resolution

LVEDV:

Left ventricular end diastolic volume

LVESV:

Left ventricular end systolic volume

LVEF:

Left ventricular ejection fraction

MPI:

Myocardial perfusion imaging

MUGA:

Multi-gated acquisition study

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Disclosure

MHI is proprietary software of the Montreal Heart Institute. Matthieu Pelletier-Galarneau, Vincent Finnerty, Stephanie Tan, Sebastien Authier, Jean Gregoire, and Francois Harel declare that they have no other conflict of interest related to this work.

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Authors and Affiliations

  1. Department of Radiology and Nuclear Medicine, Montreal Heart Institute, 5000 Belanger, Montreal, QC, H1T1C8, Canada

    Matthieu Pelletier-Galarneau MD, MSc, Vincent Finnerty MSc, Stephanie Tan MD, Sebastien Authier B Eng, Jean Gregoire MD & Francois Harel MD, PhD

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  1. Matthieu Pelletier-Galarneau MD, MSc
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  2. Vincent Finnerty MSc
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  3. Stephanie Tan MD
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  4. Sebastien Authier B Eng
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  5. Jean Gregoire MD
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  6. Francois Harel MD, PhD
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Correspondence to Matthieu Pelletier-Galarneau MD, MSc.

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Pelletier-Galarneau, M., Finnerty, V., Tan, S. et al. Assessment of left ventricular ejection fraction with cardiofocal collimators: Comparison between IQ-SPECT, planar equilibrium radionuclide angiography, and cardiac magnetic resonance. J. Nucl. Cardiol. 26, 1857–1864 (2019). https://doi.org/10.1007/s12350-018-1251-6

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  • DOI: https://doi.org/10.1007/s12350-018-1251-6

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