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Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678)

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The property profile of N-decyltropine (IEM-1556) has significant advantages over that of its prototype, the selective nicotinic receptor antagonist tert-butyldecylammonium (IEM-1678), because its anticonvulsant, antiparkinsonian, antidepressant, and analgesic activities are significantly greater and its therapeutic index is 2.8 times higher than that of IEM-1678. The higher pharmacological activity and lower toxicity of IEM-1556 are explained by the fact that IEM-1556 not only blocks nicotinic receptors but also stimulates subdiaphragmatic vagal afferents.

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Authors and Affiliations

  1. Institute of Experimental Medicine, 12 Acad. Pavlov St., St. Petersburg, 197376, Russia

    V. E. Gmiro & S. E. Serdyuk

Authors
  1. V. E. Gmiro
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  2. S. E. Serdyuk
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Correspondence to V. E. Gmiro.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 3, pp. 21 – 25, March, 2019.

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Gmiro, V.E., Serdyuk, S.E. Synthesis and Pharmacological Properties of N-Decyltropine (IEM-1556) as Compared to Selective Nicotinic Receptor Antagonist Tert-Butyldecylammonium (IEM-1678). Pharm Chem J 53, 212–215 (2019). https://doi.org/10.1007/s11094-019-01981-6

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  • DOI: https://doi.org/10.1007/s11094-019-01981-6

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