Skip to main content
SpringerLink
Log in

Synthesis and Pharmacological Properties of 1-(6-Aminohexylamino)-1-Phenylcyclohexyl Dihydrochloride (IEM-2062) as Compared with Memantine

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

1-(6-Aminohexylamino)-1-phenylcyclohexyl dihydrochloride (IEM-2062) had significantly greater antihypoxic, anticonvulsant, antidepressant, and analgesic activity than memantine and similar antiparkinsonism activity as memantine; it had low toxicity and was safer for use. IEM-2062 produced significant pharmacological effects in the dose range 0.3 – 3 mg/kg.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1.

Similar content being viewed by others

References

  1. S. I. Gavrilova, Psikhiatriya Psikhofarmakoter., 7(2), 72 – 76 (2005).

    Google Scholar 

  2. O. S. Levin and L. A. Batukaeva, Zh. Nevrol. Psikhiat. im. S. S. Korsakova, 108(12), 16 – 23 (2008).

    CAS  Google Scholar 

  3. G. Rammes, W. Danysz, and C. G. Parsons, Curr. Neuropharmacol., 6(1), 55 – 78 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. W. Danysz, C. G. Parsons, J. Kornhuber, et al., Neurosci. Biobehav. Rev., 21(4), 455 – 468 (1997).

    Article  CAS  PubMed  Google Scholar 

  5. C. G. Parsons, W. Danysz, and G. Quack, Neuropharmacol., 38(6), 735 – 767 (1999).

    Article  CAS  Google Scholar 

  6. K. K. Jain, Expert. Opin. Investig. Drugs, 9(6), 1397 – 1406 (2000).

    Article  CAS  PubMed  Google Scholar 

  7. G. C. Palmer, Curr. Drug Targets, 2(3), 241 – 271 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. M. Rogers, A. Rasheed, A. Moradimeh, and S. J. Baumrucker, Am. J. Hosp. Palliat. Care, 26(1), 57 – 59. Review (2009).

    Article  PubMed  Google Scholar 

  9. K. Zdanys and R. R. Tampi, Prog. Neuropsychopharmacol. Biol. Psychiatry, 32(6), 1362 – 1374, Review (2008).

    Article  CAS  PubMed  Google Scholar 

  10. G. Rammes, W. Danysz, and C. G. Parsons, Curr. Neuropharmacol., 6(1), 55 – 78 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. C. Ikonomidou and V. Stefovska, Proc. Natl. Acad. Sci. USA, 97(23), 12885 – 12890 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. V. E. Gmiro and S. E. Serdyuk, Éksperim. Klin. Farmakol., 63(6), 3 – 8 (2000).

    CAS  Google Scholar 

  13. C. G. Parsons, G. Quack, I. Bresink, et al., Neuropharmacology, 34(10), 1239 – 1258 (1995).

    Article  CAS  Google Scholar 

  14. V. E. Gmiro, S. E. Serdyuk, O. S. Veselkina, Byul. Éksperim. Biol. Med., 160(7), 80 – 83 (2015).

    Google Scholar 

  15. I. M. Fedorova, V. E. Gmiro, L. G. Magazanik, and D. B. Tikhonov, Zh. Évol. Biokhim. Fiziol., 44(6), 556 – 562 (2008).

    CAS  PubMed  Google Scholar 

  16. M. Makosza and B. Serafin, Przem. Chem., 46(7), 393 – 394 (1967).

    CAS  Google Scholar 

  17. V. H. Maddox, E. F. Godefroi, and R. F. Parcell, J. Med. Chem., 8(2), 230 – 235 (1965).

    Article  CAS  PubMed  Google Scholar 

  18. Lancaster, Chemist’s Catalogue (2000 – 2001, p. 276.

  19. I. A. Revel’skii, E. N. Kapinus, M. V. Fedoseeva, et al., Zh. Anal. Khimii, 64(9), 949 – 953 (2009).

    Google Scholar 

  20. Guidelines for Preclinical Studies of Drugs [in Russian], A. N. Mironov (ed.), Grif i K, Moscow (2012), part 1.

  21. V. E. Gmiro and S. E. Serdyuk, Éksperim. Klin. Farmakol., 63(6), 3 – 8 (2000).

    CAS  Google Scholar 

  22. S. E. Krahl, S. S. Senanayake, and A. Handforth, Epilepsy Res., 38(2 – 3), 171 – 175 (2000).

    Article  CAS  PubMed  Google Scholar 

  23. A. Campbell, R. J. Baldessarini, and M. C. Cremens, Neuropharmacology, 27(11), 1197 – 1199 (1988).

    Article  CAS  PubMed  Google Scholar 

  24. V. E. Gmiro and S. E. Serdyuk, Byul. Éksperim. Biol. Med., 143(5), 554 – 556 (2007).

    Google Scholar 

  25. S. E. Serdyuk and V. E. Gmiro, Byul. Éksperim. Biol. Med., 144(11), 535 – 537 (2007).

    Google Scholar 

  26. C. J. Woolf, G. D. Barrett, D. Mitchell, and R. A. Myers, Eur. J. Pharmacol., 45(3), 311 – 314 (1977).

    Article  CAS  PubMed  Google Scholar 

  27. R. D. Porsolt, G. Anton, N. Blavet, and M. Jalfre, Eur. J. Pharmacol., 47(4), 379 – 391 (1978).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Experimental Medicine, 12 Academician Pavlov Street, 197376, St. Petersburg, Russia

    V. E. Gmiro & S. E. Serdyuk

  2. ZAO Vertex Pharmaceutical Company, 27A 24th Line, Vasilevskii Ostrov, 199106, St. Petersburg, Russia

    O. S. Veselkina

Authors
  1. V. E. Gmiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. E. Serdyuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. S. Veselkina
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. E. Gmiro.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 1, pp. 30 – 35, January, 2019.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gmiro, V.E., Serdyuk, S.E. & Veselkina, O.S. Synthesis and Pharmacological Properties of 1-(6-Aminohexylamino)-1-Phenylcyclohexyl Dihydrochloride (IEM-2062) as Compared with Memantine. Pharm Chem J 53, 29–34 (2019). https://doi.org/10.1007/s11094-019-01950-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-019-01950-z

Keywords

Search

Navigation