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Synthesis and application of magnetic molecularly imprinted polymers in sample preparation

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Abstract

Magnetic molecularly imprinted polymers (MMIPs) have superior advantages in sample pretreatment because of their high selectivity for target analytes and the fast and easy isolation from samples. To meet the demand of both good magnetic property and good extraction performance, MMIPs with various structures, from traditional core–shell structures to novel composite structures with a larger specific surface area and more accessible binding sites, are fabricated by different preparation technologies. Moreover, as the molecularly imprinted polymer (MIP) layers determine the affinity, selectivity, and saturated adsorption amount of MMIPs, the development and innovation of the MIP layer are attracting attention and are reviewed here. Many studies that used MMIPs as sorbents in dispersive solid-phase extraction of complex samples, including environmental, food, and biofluid samples, are summarized.

The application of magnetic molecularly imprinted polymers (MIPs) in the sample preparation procedure improves the analytical performances for complex samples. MITs molecular imprinting technologies

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Abbreviations

ATRP:

Atom transfer radical polymerization

BPA:

Bisphenol A

CNT:

Carbon nanotube

DSPE:

Dispersive solid-phase extraction

EGDMA:

Ethylene glycol dimethacrylate

Fe3O4@SiO2 :

Silica-coated Fe3O4

FRP:

Free-radical polymerization

GO:

Graphene oxide

HPLC:

High-performance liquid chromatography

IF:

Imprinting factor

IIP:

Ion-imprinted polymer

LCRP:

Living/controlled radical polymerization

LOD:

Limit of detection

MAA:

Methacrylic acid

MIP:

Molecularly imprinted polymer

MIT:

Molecular imprinting technology

MMIP:

Magnetic molecularly imprinted polymer

MNP:

Magnetic nanoparticle

MPS :

3-(Methacryloxy)propyl trimethoxysilane

RAFT:

Reversible addition fragmentation chain transfer

si-ATRP:

Surface-initiated atom transfer radical polymerization

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Acknowledgements

Financial support from the National Natural Science Foundation of China (grants 21377172, 21225731, 21477166, 21527813, and 21225731) and the Natural Science Foundation of Guangdong Province (grant S2013030013474) is gratefully acknowledged.

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Authors and Affiliations

  1. Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China

    Shuyao Huang, Jianqiao Xu, Jiating Zheng, Fang Zhu & Gangfeng Ouyang

  2. Department of Chemistry, Guangdong University of Education, Guangzhou, Guandong, 510303, China

    Lijun Xie

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  1. Shuyao Huang
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  2. Jianqiao Xu
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  3. Jiating Zheng
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  4. Fang Zhu
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Huang, S., Xu, J., Zheng, J. et al. Synthesis and application of magnetic molecularly imprinted polymers in sample preparation. Anal Bioanal Chem 410, 3991–4014 (2018). https://doi.org/10.1007/s00216-018-1013-y

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  • DOI: https://doi.org/10.1007/s00216-018-1013-y

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