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CLAs in Animal Source Foods: Healthy Benefits for Consumers

Bioactive Molecules in Food

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Conjugated linoleic acid (CLA) is a group of polyunsaturated fatty acids that exist as positional and stereo-isomers of octadecadienoate (18:2). Among these isomers, the most studied two isomers are cis 9, trans 11-CLA and trans 10, cis 12-CLA due to their biological effects. CLA can be naturally synthesized in the rumen of ruminant animals by bacteria Butyrivibrio fibrisolvens via the Δ-9-desaturase of trans 11 octadecanoic acid pathway. The major dietary sources of CLA are represented by meat and milk from ruminant animals. Although references to CLA can be traced back to the 1950s, current interest in the health benefits of CLA started in the late 1980s, after it was identified as the anti-carcinogenic component present in fried ground beef. Since then, an extensive literature has documented the anticarcinogenic effects of CLA. In addition, there is some evidence that CLA is also anti-atherosclerotic, has beneficial effects on type 2 diabetes, and may play a key role in helping to regulate body fat. The fact that the richest natural sources of CLA, meat and dairy products, are consumed by people worldwide has very interesting implications for public health.

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Abbreviations

CLA:

Conjugated Linoleic Acid

DHA:

Docosahexaenoic acid

EPA:

Eicosapentaenoic acid

FAME:

Fatty Acid Methyl Ester

MUFA:

Monounsaturated Fatty Acids

PUFA:

Polyunsaturated Fatty Acids

SFA:

Saturated Fatty Acids

TFA:

Trans Fatty Acids

References

  1. de Castro Cardoso Pereira PM, dos Reis Baltazar Vicente AF (2013) Meat nutritional composition and nutritive role in the human diet. Meat Sci 93:586–592

    Article  CAS  Google Scholar 

  2. Wang WJ, Crompton RH (2004) The role of load-carrying in the evolution of modern body proportions. J Anat 204:417–430

    Article  Google Scholar 

  3. Speth JD (1989) Early hominid hunting and scavenging: the role of meat as an energy source. J Human Evol 18:329–343

    Article  Google Scholar 

  4. Mann N (2007) Meat in the human diet: an anthropological perspective. Nutr Dietet 64(s4):S102–S107

    Article  Google Scholar 

  5. Valsta LM, Tapanainen H, Männistö S (2005) Meat fats in nutrition. Meat Sci 70:525–530

    Article  CAS  Google Scholar 

  6. Binnie MA, Barlow K, Johnson V, Harrison C (2014) Red meats: time for a paradigm shift in dietary advice. Meat Sci 98:445–451

    Article  Google Scholar 

  7. Toldrá F, Reig M (2012) Biochemistry of raw meat and poultry. In: Simpson BK, Nollet LML, Toldrá F, Benjakul S, Paliyath G, Hui YH (eds) Food biochemistry and food processing, 2nd edn. Wiley, New York

    Google Scholar 

  8. Toldrá F, Flores M (2004) Analysis of meat quality. In: Nollet LML (ed) Handbook of food analysis. Marcel Dekker, New York

    Google Scholar 

  9. Jakobsen K (1999) Dietary modifications of animal fats: status and future perspectives. Fett-Lipid 101:475–483

    Article  Google Scholar 

  10. Kauffman RG (2001) Meat composition. In: Hui YH, Nip WK, Rogers RW, Young OA (eds) Meat science and applications. Marcel Dekker, New York

    Google Scholar 

  11. Smith SB, Smith DR, Lunt DK (2004) Adipose tissue. In: Jensen WK, Devine C, Dikeman M (eds) Encyclopedia of meat sciences. Elsevier Academic Press, Oxford

    Google Scholar 

  12. Webb EC, O’Neill HA (2008) The animal fat paradox and meat quality. Meat Sci 80:28–36

    Article  CAS  Google Scholar 

  13. IUPAC-IUB Commission on Biochemical Nomenclature (1978) The nomenclature of lipids. J Lipid Res 19:114–129

    Google Scholar 

  14. Wood JD, Enser M, Fisher AV, Nute GR, Sheard PR, Richardson RI, Hughes SI, Whittington FM (2008) Fat deposition, fatty acid composition and meat quality: a review. Meat Sci 78:343–358

    Article  CAS  Google Scholar 

  15. Teye GA, Sheard PR, Whittington FM, Nute GR, Stewart A, Wood JD (2006) Influence of dietary oils and protein level on pork quality. 1. Effects on muscle fatty acid composition, carcass, meat and eating quality. Meat Sci 73:157–165

    Article  CAS  Google Scholar 

  16. Doreau M, Ferlay A (1994) Digestion and utilisation of fatty acids by ruminants. Anim Feed Sci Technol 45:379–396

    Article  CAS  Google Scholar 

  17. Smith WL (2007) Nutritionally essential fatty acids and biologically indispensable cyclooxygenases. Trends Biochem Sci 33(1):27–37

    Article  CAS  Google Scholar 

  18. Seppänen-Laakso T, Laakso I, Hiltunen R (2002) Analysis of fatty acids by gas chromatography, and its relevance to research on health and nutrition. Anal Chim Acta 465:39–62

    Article  Google Scholar 

  19. Smith SB, Smith DR, Lunt DK (2004) Adipose tissue. In: Jensen WK, Devine C, Dikeman M (eds) Encyclopedia of meat sciences. Elsevier Academic Press, Oxford, UK

    Google Scholar 

  20. Enser M, Richardson RI, Wood JD, Gill BP, Sheard PR (2000) Feeding linseed to increase the n-3 PUFA of pork: fatty acid composition of muscle, adipose tissue, liver and sausages. Meat Sci 55:201–212

    Article  CAS  Google Scholar 

  21. Morgan CA, Noble RC, Cocchi M, McCartney R (1992) Manipulation of the fatty acid composition of pig meat lipids by dietary means. J Sci Food Agric 58:357–368

    Article  CAS  Google Scholar 

  22. Enser M, Hallett KG, Hewett B, Fursey GAJ, Wood OJD, Harringtonb G (1998) Fatty acid content and composition of UK beef and lamb muscle in relation to production system and implications for human nutrition. Meat Sci 49:329–341

    Article  CAS  Google Scholar 

  23. Buckely DJ, Morrissey PA, Gray JI (1995) Influence of dietary vitamin E on the oxidative stability and quality of pig meat. J Anim Sci 73:3122–3130

    Article  Google Scholar 

  24. Belury MA (2002) Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Ann Rev Nutr 22:505–531

    Article  CAS  Google Scholar 

  25. Fernández X, Mourot J, Mounier A, Ecolan P (1995) Effect of muscle type and food deprivation for 24 hours on the composition of the lipid fraction in muscles of large white pigs. Meat Sci 41:335–343

    Article  Google Scholar 

  26. Shorland FB (1950) Effect of the dietary fat on the composition of the depot fats of animals. Nature 165:766

    Article  CAS  Google Scholar 

  27. Parodi PW (1999) Conjugated linoleic acid: the early years. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  28. Hartman L, Shorland FB, McDonald IRC (1955) The trans-unsaturated acid contents of fats of ruminants and non-ruminants. Biochem J 61:603–607

    Article  CAS  Google Scholar 

  29. Hansen RP, Czochanska Z (1976) Fatty acid composition of the subcutaneous and perinephric fats of lambs grazed on pastures in New Zealand. N Z J Sci 19:413–419

    CAS  Google Scholar 

  30. McGuire M, McGuire MA, Ritzenthalera K, Shultz TD (1999) Dietary sources and intakes of conjugated linoleic acid intake in humans. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  31. Kramer JKG, Parodi PW, Jensen RG, Mossoba MM, Yurawecz MP, Adlof RO (1998) Rumenic acid: a proposed common name for the major conjugated linoleic acid isomer found in natural products. Lipids 33:835

    Article  CAS  Google Scholar 

  32. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW (1992) Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Compos Anal 5:185–197

    Article  CAS  Google Scholar 

  33. Crumb DJ (2011) Conjugated linoleic acid – an overview. Int J Appl Res Nat Prod 4:12–18

    CAS  Google Scholar 

  34. Bauman DE, Baumgard LH, Corl BA, Griinari JM (1999) Biosynthesis of conjugated linoleic acid in ruminants. Proc Am Soc Ani Sci 1–15

    Google Scholar 

  35. Khanal RC, Olson KC (2004) Factors affecting conjugated linoleic acid (CLA) content in milk, meat, and egg: a review. Pakistan J Nutr 3:82–98

    Article  Google Scholar 

  36. Griinari JM, Bauman DE (1999) Biosynthesis of conjugated linoleic acid and its incorporation into meat and milk in ruminants. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  37. Reiser R (1951) Hydrogenation of polyunsaturated fatty acids by the ruminant. Fed Proc 10:236

    Google Scholar 

  38. Shorland FB, Weenink RO, Johns AT (1955) Effect of the rumen on dietary fat. Nature 175:1129–1130

    Article  CAS  Google Scholar 

  39. Shorland FB, Weenink RO, Johns AT, McDonald IRC (1957) The effect of shee-rumen contents on unsaturated fatty acids. Biochem J 67:328–333

    Article  CAS  Google Scholar 

  40. Kepler CR, Tove SB (1967) Biohydrogenation of unsaturated fatty acids. J Biol Chem 242:5686–5692

    CAS  Google Scholar 

  41. Khanal RC, Dhiman TR (2004) Biosynthesis of conjugated linoleic acid: a review. Pakistan J Nutr 3:72–81

    Article  Google Scholar 

  42. Harfoot CG, Hazlewood GP (1988) Lipid metabolism in the rumen. In: Hobson PN (ed) The rumen microbial ecosystem. Elsevier, London

    Google Scholar 

  43. Kepler CR, Tucker WP, Tove SB (1970) Biohydrogenation of unsaturated fatty acids. IV. Substrate specificity and inhibition of linoleate 12-cis 11-trans isomerase from Butyrivibrio fibrisolvens. J Biol Chem 245:3612–3620

    CAS  Google Scholar 

  44. Keeny M (1970) Lipid metabolism in the rumen. In: Phillipson AT (ed) Physiology of digestion and metabolism in the ruminant. Oriel Press, Newcastle-upon-Tyne

    Google Scholar 

  45. Noble RC, Moore JH, Harfoot CG (1974) Observations on the pattern of esterified and unesterified linoleic acid in the rumen. Br J Nutr 31:99–108

    Article  CAS  Google Scholar 

  46. Griinari JM, Dwyer DA, McGuire MA, Bauman DE, Palmquist DL, Nurmela KVV (1998) Trans-octadecenoic acids and milk fat depression in lactating dairy cows. J Dairy Sci 81:1251–1261

    Article  CAS  Google Scholar 

  47. Verhulst A, Janssen G, Parmentier G, Eyssen H (1987) Isomerization of polyunsaturated fatty acids by Propionibacteria. Syst Appl Microbiol 9:12–15

    Article  CAS  Google Scholar 

  48. Kim YJ, Liu RH, Bond DR, Russell JB (2000) Effect of linoleic acid concentration on conjugated linoleic acid by Butyrivibrio fibrisolvens A38. Appl Environ Microbiol 66:5226–5230

    Article  CAS  Google Scholar 

  49. Troegeler-Meynadir A, Nicot MC, Bayourthe C, Moncoulon R, Enjalbert F (2003) Effects of pH and concentrations of linoleic acids on extent and intermediates of ruminal biohydrogenation in vitro. J Dairy Sci 86:4054–4063

    Article  Google Scholar 

  50. Donovan DC, Schingoethe DJ, Baer RJ, Ryali J, Hippen AR, Franklin ST (2000) Influence of dietary fish oil on conjugated linoleic acid and other fatty acids in milk fat from lactating dairy cows. J Dairy Sci 83:2620–2628

    Article  CAS  Google Scholar 

  51. Banni S, Carta C, Contini MS, Angioni E, Deiana M, Dessi MA, Melis MP, Corongiu FP (1996) Characterization of conjugated diene fatty acids in milk, dairy products and lamb tissues. J Nutr Biochem 7:150–155

    Article  CAS  Google Scholar 

  52. Chouinard PY, Corneau L, Bauman DE, Butler WR, Chiliard Y, Drackley JK (1998) Conjugated linoleic acid content of milk from cows fed different sources of dietary fat. J Dairy Sci 81(suppl 1):223

    Google Scholar 

  53. Parodi PW (1994) Conjugated linoleic acid: an anticarcinogenic fatty acid present in milk fat. Aust J Dairy Tech 40:93–97

    Google Scholar 

  54. Griinari JM, Corl BA, Lacy SH, Chouinard PY, Nurmela KVV, Bauman DE (2000) Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Δ9-desaturase. J Nutr 130:2285–2291

    CAS  Google Scholar 

  55. Lock AL, Garnsworthy PC (2002) Independent effects of dietary linoleic and linolenic fatty acids on the conjugated linoleic acid content of cows’milk. Anim Sci 74:163–176

    CAS  Google Scholar 

  56. Kay JK, Mackle TR, Auldist MJ, Thompson NA, Bauman DE (2002) Endogenous synthesis of cis-9, trans-11 conjugated linoleic acid in pasture-fed dairy cows. J Dairy Sci 85(suppl 1):176

    Google Scholar 

  57. Khanal RC, Dhiman TR, McMahon DJ, Boman RL (2002) Influence of diet on conjugated linoleic acid content of milk, cheese and blood serum. J Dairy Sci 85(Suppl. 1):142

    Google Scholar 

  58. Bolte MR, Hess BW, Means WJ, Moss GE, Rule DC (2002) Feeding lambs high-oleate or high linoleate safflower seeds differentially influences carcass fatty acid composition. J Anim Sci 80:609–616

    Article  CAS  Google Scholar 

  59. Chilliard Y, Ferlay A, Rouel J, Lamberet G (2003) A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis. J Dairy Sci 86:1751–1770

    Article  CAS  Google Scholar 

  60. Fritsche J, Rickert R, Steinhart H, Yurawecz MP, Mossoba MM, Sehat N, Roach JAG, Kramer JKG, Ku Y (1999) Conjugated linoleic acid (CLA) isomers: formation, analysis, amounts in foods, and dietary intake. Fett-Lipid 101:272–276

    Article  CAS  Google Scholar 

  61. Kelly ML, Berry JR, Dwyer DA, Griinari JM, Chouinard PY, Van Amburgh ME, Bauman DE (1998) Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J Nutr 128:881–885

    CAS  Google Scholar 

  62. Jahreis G, Fritsche J, Steinhart H (1997) Conjugated linoleic acid in milk fat: high variation depending on production system. Nutr Res 17:1479–1484

    Article  CAS  Google Scholar 

  63. Sauer FD, Fellner V, Kinsman R, Kramer JKG, Jackson HA, Lee AJ, Chen S (1998) Methane output and lactation response in holstein cattle with Monensin or unsaturated fat added to the diet. J Anim Sci 76:906–914

    Article  CAS  Google Scholar 

  64. Jiang J, Bjoerck L, Fondén R (1997) Conjugated linoleic acid in Swedish dairy products with special reference to the manufacture of hard cheeses. Int Dairy J 7:863–867

    Article  CAS  Google Scholar 

  65. Rule DC, Broughton KS, Shellito SM, Maiorano G (2002) Comparison of muscle fatty acid profiles and cholesterol concentrations of bison, beef cattle, elk, and chicken. J Anim Sci 80:1202–1211

    Article  CAS  Google Scholar 

  66. Engelke CF, Siebert BD, Gregg K, Wright ADG, Vercoe PE (2004) Kangaroo adipose tissue has higher concentrations of cis 9, trans 11-conjugated linoleic acid than lamb adipose tissue. J Anim Feed Sci 13:689–692

    Article  Google Scholar 

  67. Schmid A, Collomb M, Sieber R, Bee G (2006) Conjugated linoleic acid in meat and meat products: a review. Meat Sci 73:29–41

    Article  CAS  Google Scholar 

  68. Badiani A, Montellato L, Bochicchio D, Anfossi P, Zanardi E, Maranesi M (2004) Selected nutrient contents, fatty acid composition, including conjugated linoleic acid, and retention values in separable lean from lamb rib loins as affected by external fat and cooking method. J Agric Food Chem 52:5187–5194

    Article  CAS  Google Scholar 

  69. Shantha NC, Crum AD, Decker EA (1994) Evaluation of conjugated linoleic-acid concentrations in cooked beef. J Agric Food Chem 42:1757–1760

    Article  CAS  Google Scholar 

  70. Zhang W, Xiao S, Samaraweera H, Lee EJ, Ahn DU (2010) Improving functional value of meat products. Meat Sci 86:15–31

    Article  CAS  Google Scholar 

  71. Serra A, Mele M, La Comba F, Conte G, Buccioni A, Secchiari P (2009) Conjugated linoleic acid (CLA) content of meat from three muscles of Massese suckling lambs slaughtered at different weights. Meat Sci 81:396–404

    Article  CAS  Google Scholar 

  72. Mulvihill B (2001) Ruminant meat as a source of conjugated linoleic acid (CLA). Nutr Bull 26:295–299

    Article  Google Scholar 

  73. Dugan MER, Aalhus JL, Kramer JKG (2004) Conjugated linoleic acid pork research. Amer J Clin Nutr 79:1212–1216

    Google Scholar 

  74. Gatlin LA, See MT, Larick DK, Lin X, Odle J (2002) Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. J Nutr 132:3105–3112

    CAS  Google Scholar 

  75. Corino C, Pastorelli G, Douard V, Rossi R, Musella M, Mourot J (2006) L’acide linoléique conjugué en nutrition porcine. INRA Prod Anim 19:39–46

    CAS  Google Scholar 

  76. Dugan MER, Aalhus JL, Shaefer AL, Kramer JKG (1997) The effect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can J Anim Sci 77:723–725

    Article  CAS  Google Scholar 

  77. Corino C, Musella M, Pastorelli G, Rossi R, Paolone K, Costanza L, Manchisi A, Maiorano G (2008) Influences of dietary conjugated linoleic acid (CLA) and total lysine content on growth, carcass characteristics and meat quality of heavy pigs. Meat Sci 79:307–316

    Article  CAS  Google Scholar 

  78. Corino C, Filetti F, Gambacorta M, Manchisi A, Magni S, Pastorelli G, Rossi R, Maiorano G (2003) Influence of dietary conjugated linoleic acids (CLA) and age at slaughtering on meat quality and intramuscular collagen in rabbits. Meat Sci 66:97–103

    Article  CAS  Google Scholar 

  79. Corino C, Lo Fiego DP, Macchioni P, Pastorelli G, Di Giancamillo A, Domeneghini C, Rossi R (2007) Influence of dietary conjugated linoleic acids and vitamin E on meat quality, and adipose tissue in rabbits. Meat Sci 76:19–28

    Article  CAS  Google Scholar 

  80. Dufey PA (1999) Fleisch ist eine CLA-Nahrungsquelle. Agrarforschung 6:177–180

    Google Scholar 

  81. Lorenzo JM, Sarriés MV, Tateo A, Polidori P, Franco D, Lanza M (2014) Carcass characteristics, meat quality and nutritional value of horsemeat: a review. Meat Sci 96:1478–1488

    Article  CAS  Google Scholar 

  82. Polidori P, Pucciarelli S, Ariani A, Polzonetti V, Vincenzetti S (2015) A comparison of the carcass and meat quality of Martina Franca donkey foals aged 8 or 12 months. Meat Sci 206:6–10

    Article  CAS  Google Scholar 

  83. Sirri F, Tallarico N, Meluzzi A, Franchini A (2003) Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. Poult Sci 82:1356–1361

    Article  CAS  Google Scholar 

  84. Grashorn MA (2005) Enrichment of eggs and poultry meat with biologically active substances by feed modifications and effects on the final quality of the product. Pol J Food Nutr Sci 14:15–20

    CAS  Google Scholar 

  85. Du M, Ahn DU (2002) Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. Poultry Sci 81:428–433

    Article  CAS  Google Scholar 

  86. Ahn DU, Sell JL, Jo C, Chamruspollert M, Jeffrey M (1999) Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. Poultry Sci 78:922–928

    Article  CAS  Google Scholar 

  87. Belury MA, Kempa-Steczko A (1997) Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids 32:199–204

    Article  CAS  Google Scholar 

  88. Kromhout D, Bosschieter EB, de Lezenne Coulander C (1985) The inverse relation between fish consumption and 20-year mortality from coronary heart disease. N Engl J Med 312:1205–1209

    Article  CAS  Google Scholar 

  89. Ackman RG (1999) Conjugated linoleic acid (CLA) in lipids of fish tissues. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  90. Dhiman TR, Nam SH, Ure AL (2009) Factors affecting conjugated linoleic acid content in milk and meat. Crit Rev Food Sci Nutr 45:463–482

    Article  CAS  Google Scholar 

  91. Dhiman TR, Anand GR, Satter LD, Pariza MW (1999) Conjugated linoleic acid content of milk from cows fed different diets. J Dairy Sci 82:2146–2156

    Article  CAS  Google Scholar 

  92. Garcia-Lopez S, Echeverria E, Tsui I, Balch B (1994) Changes in the content of conjugated lionleic acid (CLA) in processed cheese during processing. Food Res Int 27:61–64

    Article  CAS  Google Scholar 

  93. Shantha NC, Ram LN, O’Leary J, Hicks CL, Decker EA (1995) Conjugated linoleic acid concentrations in dairy products as affected by processing and storage. J Food Sci 60:695–697

    Article  CAS  Google Scholar 

  94. Scimeca JA (1999) Cancer inhibition in animals. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  95. Ferguson LR (2010) Meat and cancer. Meat Sci 84:308–313

    Article  CAS  Google Scholar 

  96. Santarelli RL, Pierre F, Corpet DE (2008) Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutr Cancer 60:131–144

    Article  CAS  Google Scholar 

  97. Wood JD, Enser M (1997) Factors influencing fatty acids in meat and the role of antioxidant in improving meat quality. British J Nutr 78(Suppl 1):S49–S60

    Article  CAS  Google Scholar 

  98. Wyness L, Weichselbaum E, O'Connor A, Williams EB, Benelam B, Riley H, Stanner S (2011) Red meat in the diet: an update. Brit Nutr Found Nutr Bull 36:34–77

    Article  Google Scholar 

  99. Lavillonnière F, Bougnoux P (1999) Conjugated linoleic acid (CLA) and the risk of breast cancer. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  100. Ip C (1997) Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. Am J Clin Nutr 66:1523S–1529S

    CAS  Google Scholar 

  101. Ha YL, Grimm NK, Pariza MW (1989) Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J Agric Food Chem 37:75–81

    Article  CAS  Google Scholar 

  102. Ip C, Chin SF, Scimeca JA, Pariza MW (1991) Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 51:6118–6124

    CAS  Google Scholar 

  103. Cesano A, Visonneau S, Scimeca JA, Kritchevsky D, Santoli D (1998) Opposite effects of linoleic acid and Conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res 18:1429–1434

    CAS  Google Scholar 

  104. Ovesen L (2004) Cardiovascular and obesity health concern. In: Jensen WK, Devine C, Dikeman M (eds) Encyclopedia of meat sciences. Elsevier Academic Press, Oxford

    Google Scholar 

  105. Nelson GJ (1998) Dietary fat, trans fatty acids, and risk of coronary heart disease. Nutr Rev 56:250–252

    Article  CAS  Google Scholar 

  106. Khosla P, Fungwe TV (2001) Conjugated linoleic acid: effects on plasma lipids and cardiovascular function. Curr Opin Lipidol 12:31–34

    Article  CAS  Google Scholar 

  107. Kritchevsky D (2000) Antimutagenic and some other effects of conjugated linoleic acid. Br J Nutr 83:459–465

    CAS  Google Scholar 

  108. Nicolosi RJ, Rogers EJ, Kritchevsky D, Scimeca JA, Huth PJ (1997) Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22:266–277

    CAS  Google Scholar 

  109. Atkinson RL (1999) Conjugated Linoleic Acid for altering body composition and treating obesity. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  110. Liu KL, Belury MA (1998) Conjugated linoleic acid reduces arachidonic acid content and PGE(2) synthesis in murine keratinocytes. Cancer Lett 127:15–22

    Article  CAS  Google Scholar 

  111. Turek JJ, Li Y, Schoenlein IA, Allen KGD, Watkins BA (1998) Modulation of macrophage cytokine production by Conjugated Linoleic acids is influenced by the dietary n-6–n-3 fatty acid ratio. J Nutr Biochem 9:258–266

    Article  CAS  Google Scholar 

  112. Sasaki N, Uchida E, Niiyama M, Yoshida T, Saito M (1998) Anti-obesity effects of selective agonists to the beta 3-adrenergic receptor in dogs. II. Recruitment of thermogenic brown adipocytes and reduction of adiposity after chronic treatment with a beta 3-adrenergic agonist. J Vet Med Sci 60:465–469

    Article  CAS  Google Scholar 

  113. Liu YL, Toubro S, Astrup A, Stock MJ (1995) Contribution of β3-adrenoceptor activation to ephedrine-induced thermogenesis in humans. Int J Obes 19:678–685

    CAS  Google Scholar 

  114. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldbery AF, Schlenker RA, Cohn L, Rudman IW, Mattson DE (1990) Effects of human growth hormone in men over 60 years old. N Engl J Med 323:1–6

    Article  CAS  Google Scholar 

  115. Chin SF, Storkson JM, Albright KJ, Cook ME, Pariza MW (1994) Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency. J Nutr 124:2344–2349

    CAS  Google Scholar 

  116. Kreider R, Ferreira M, Greenwood M, Almada A (2002) Effects of conjugated linoleic acid (CLA) supplementation during resistance training on body composition, bone density, strength and selected hematological markers. J Strength Conditioning Res 16:325–334

    Google Scholar 

  117. Silveira MB, Carraro R, Monerero S, Tébar J (2007) Conjugated linoleic acid (CLA) and obesity. Public Health Nutr 10(10A):1181–1186

    Article  Google Scholar 

  118. Belury MA, Vanden Heuven JP (1999) Modulation of diabetes by conjugated linoleic acid. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds) Advances in conjugated linoleic acid research, vol 1. AOCS Press, Champaign

    Google Scholar 

  119. Stangl GI, Muller H, Kirchgessner M (1999) Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins, and its proportion in fasting serum and erythrocyte membranes of swine. Eur J Nutr 38:271–277

    Article  CAS  Google Scholar 

  120. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim H-J, Tange T, Okuyama H, Kasai M, Ikemoto S, Ezaki O (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49:1534–1542

    Article  CAS  Google Scholar 

  121. Medina EA, Horn WF, Keim NL, Havel PJ, Benito P, Kelley DS, Nelson GJ, Erickson KL (2000) Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids 35:783–788

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Pharmacy, University of Camerino, Camerino (MC), Italy

    Paolo Polidori

  2. School of Biosciences and Veterinary Sciences, University of Camerino, Camerino (MC), Italy

    Silvia Vincenzetti, Stefania Pucciarelli & Valeria Polzonetti

Authors
  1. Paolo Polidori
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  2. Silvia Vincenzetti
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  3. Stefania Pucciarelli
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  4. Valeria Polzonetti
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Corresponding author

Correspondence to Paolo Polidori .

Editor information

Editors and Affiliations

  1. Gr. d'Etude Subst. Vég. à Act. Biol, Institut des Sciences de la Vigne e Gr. d'Etude Subst. Vég. à Act. Biol, Villenave d'Ornon, France

    Jean-Michel Mérillon

  2. M.L. Sukhadia University , Badgaon, Rajasthan, India

    K.G. Ramawat

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Polidori, P., Vincenzetti, S., Pucciarelli, S., Polzonetti, V. (2018). CLAs in Animal Source Foods: Healthy Benefits for Consumers. In: Mérillon, JM., Ramawat, K. (eds) Bioactive Molecules in Food. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-54528-8_51-1

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  • DOI: https://doi.org/10.1007/978-3-319-54528-8_51-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-54528-8

  • Online ISBN: 978-3-319-54528-8

  • eBook Packages: Springer Reference Chemistry and Mat. ScienceReference Module Physical and Materials ScienceReference Module Chemistry, Materials and Physics

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  1. Latest

    CLAs in Animal Source Foods: Healthy Benefits for Consumers
    Published:
    01 February 2018

    DOI: https://doi.org/10.1007/978-3-319-54528-8_51-2

  2. Original

    CLAs in Animal Source Foods: Healthy Benefits for Consumers
    Published:
    24 October 2017

    DOI: https://doi.org/10.1007/978-3-319-54528-8_51-1

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