Articles

1. Identification of a novel MYO1D variant associated with laterality defects, congenital heart diseases, and sperm defects in humans

   • Zhuangzhuang Yuan
   • Xin Zhu
   • Zhiping Tan

   Case Report 30 April 2024

2. Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ

   • Fei Xu
   • Han Chen
   • Junbo Ge

   Research Article 22 April 2024

3. Pathological progression of osteoarthritis: a perspective on subchondral bone

   • Xuefei Li
   • Wenhua Chen
   • Zhijun Hu

   Review 15 April 2024

4. Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

   • Yue Ma
   • Hongwei Lv
   • Wen Yang

   Review 11 April 2024

5. Dysregulated N⁶-methyladenosine modification in peripheral immune cells contributes to the pathogenesis of amyotrophic lateral sclerosis

   • Di He
   • Xunzhe Yang
   • Liying Cui

   Research Article 16 March 2024

6. A distinct “repair” role of regulatory T cells in fracture healing

   • Tingting Wu
   • Lulu Wang
   • Chen Shi

   Research Article 16 March 2024

7. Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

   • Xue Han
   • Chune Ren
   • Zhenhai Yu

   Research Article 11 March 2024

8. Immune landscape and response to oncolytic virus-based immunotherapy

   • Chaolong Lin
   • Wenzhong Teng
   • Chenghao Huang

   Review 08 March 2024

9. EBV-associated lymphoproliferative disease post-CAR-T cell therapy

   • Shiyuan Zhang
   • Xiaoxi Zhou
   • Liang Huang

   Case Report 08 February 2024

10. Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease: current knowledge and new insights

    • Yaonan Song
    • Haoran Wei
    • Dao Wen Wang

    Review Open access 01 March 2024 Pages: 31 - 45

11. Trajectory of COVID-19 response and management strategy in China: scientific rationale driven strategy adjustments

    • Zeyu Zhang
    • Yue Yan
    • Zongjiu Zhang

    Review 02 April 2024 Pages: 19 - 30

12. Emergence of SARS and COVID-19 and preparedness for the next emerging disease X

    • Ben Hu
    • Hua Guo
    • Zhengli Shi

    Review 02 April 2024 Pages: 1 - 18

13. Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

    • Tianjing Sun
    • Mo Li
    • Yuanyuan Zhang

    Review 13 January 2024

14. Unraveling the complex roles of macrophages in obese adipose tissue: an overview

    • Chang Peng
    • Jun Chen
    • Jia Li

    Review 02 January 2024

15. Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

    • Tiantian Li
    • Dongsheng Wang
    • Xiaoling Xu

    Review 29 December 2023 Pages: 1080 - 1095

16. Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

    • Dong Wei
    • Yusang Xie
    • Jieming Qu

    Review 29 December 2023 Pages: 1030 - 1046

17. Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

    • Linhua Zhao
    • Chuanxi Tian
    • Xiaolin Tong

    Review 29 December 2023 Pages: 1014 - 1029

18. Human pangenome: far-reaching implications in precision medicine

    • Yingyan Yu
    • Hongzhuan Chen

    Comment 29 December 2023

19. Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational study

    • Haoyu Wang
    • Zhengyuan Wang
    • Min Lu

    Research Article 29 December 2023

20. Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

    • Fu’an Xie
    • Yujia Niu
    • Wengang Li

    Research Article 29 December 2023

21. Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges

    • Zhichen Jiang
    • Xiaohao Zheng
    • Mingyang Liu

    Review 27 December 2023 Pages: 1135 - 1169

22. Effects and mechanisms of acupuncture on women related health

    • Huichao Qin
    • Jiaxing Feng
    • Xiaoke Wu

    Review 27 December 2023 Pages: 46 - 67

23. Cross-sectional network analysis of plasma proteins/metabolites correlated with pathogenesis and therapeutic response in acute promyelocytic leukemia

    • Niu Qiao
    • Yizhu Lyu
    • Saijuan Chen

    Research Article 27 December 2023

24. Innovation-driven trend shaping COVID-19 vaccine development in China

    • Yuntao Zhang
    • Yuxiu Zhao
    • Xiaoming Yang

    Review 16 December 2023 Pages: 1096 - 1116

25. Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma: a multi-center integrated analysis of microbiome, metabolome, and transcriptome data

    • Wenjin Chen
    • Xiuwu Pan
    • Xingang Cui

    Letter to Frontiers of Medicine 15 December 2023

26. Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

    • Yi Ding
    • Xiaoli Xu
    • Mian Li

    Research Article 05 December 2023

27. Passive antibody therapy in emerging infectious diseases

    • Xiaoming Yang

    Review 02 December 2023 Pages: 1117 - 1134

28. Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

    • Qiuyu Cao
    • Yi Ding
    • Ren Zhao

    Review 02 January 2024 Pages: 1068 - 1079

29. Epidemiology, pathogenesis, and management of Coronavirus disease 2019-associated stroke

    • Lu Liu
    • Chenxia Zhou
    • Xunming Ji

    Review 02 January 2024 Pages: 1047 - 1067

30. Revisiting China’s response to coronavirus disease 2019

    • Guangbiao Zhou
    • Saijuan Chen
    • Zhu Chen

    Editorial 01 February 2024 Pages: 1011 - 1013

31. Association between ICU quality and in-hospital mortality of V-V ECMO-supported patients—the ECMO quality improvement action (EQIA) study: a national cohort study in China from 2017 to 2019

    • Wei Cheng
    • Jieqing Chen
    • China National Critical Care Quality Control Center – the ECMO quality improvement action (EQIA) study

    Research Article 22 November 2023

32. A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus 2 infections

    • Xu Hao
    • Zhiyao Bao
    • Jieming Qu

    Research Article 18 November 2023 Pages: 169 - 179

33. Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

    • Weiwei Xian
    • Mohammad Asad
    • Linya You

    Research Article Open access 13 November 2023 Pages: 147 - 168

34. Early-life famine exposure, adulthood obesity patterns, and risk of low-energy fracture

    • Hongyan Qi
    • Chunyan Hu
    • Jieli Lu

    Research Article 08 November 2023 Pages: 192 - 203

35. Phase separation in cGAS-STING signaling

    • Quanjin Li
    • Pu Gao

    Review 31 October 2023 Pages: 855 - 866

36. A randomized, controlled, open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China

    • Jie Jin
    • Zhihua Ran
    • Udo Michael Göring

    Research Article 28 October 2023 Pages: 98 - 108

37. Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies

    • Liming Liao
    • Huilin Xu
    • Xiaofeng Zheng

    Review 28 October 2023 Pages: 805 - 822

38. Association of TRMT2B gene variants with juvenile amyotrophic lateral sclerosis

    • Yanling Liu
    • Xi He
    • Junling Wang

    Research Article 24 October 2023 Pages: 68 - 80

39. Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling

    • Yuanyuan Hao
    • Panpan Chen
    • Wenbin Qian

    Research Article 23 October 2023 Pages: 128 - 146

40. Panoramic variation analysis of a family with neurodevelopmental disorders caused by biallelic loss-of-function variants in TMEM141, DDHD2, and LHFPL5

    • Liwei Sun
    • Xueting Yang
    • Xue Zhang

    Research Article 14 October 2023 Pages: 81 - 97

41. Discovery of small molecule degraders for modulating cell cycle

    • Liguo Wang
    • Zhouli Yang
    • Yu Rao

    Review 08 November 2023 Pages: 823 - 854

42. Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

    • Fang Wang
    • Yuxing Liu
    • Rong Xiang

    Research Article 30 September 2023 Pages: 180 - 191

43. BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models

    • Beibei Jiang
    • Tong Zhang
    • Ye Liu

    Research Article 25 September 2023 Pages: 1170 - 1185

44. Lack of CFAP54 causes primary ciliary dyskinesia in a mouse model and human patients

    • Xinyue Zhao
    • Haijun Ge
    • Xue Zhang

    Research Article 19 September 2023 Pages: 1236 - 1249

45. Topological reorganization and functional alteration of distinct genomic components in gallbladder cancer

    • Guoqiang Li
    • Peng Pu
    • Yingbin Liu

    Research Article 18 September 2023 Pages: 109 - 127

46. GID complex regulates the differentiation of neural stem cells by destabilizing TET2

    • Meiling Xia
    • Rui Yan
    • Xingshun Xu

    Research Article 14 September 2023 Pages: 1204 - 1218

47. Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

    • Jie Shao
    • Wenjuan Wang
    • Jinhong Chen

    Research Article 14 September 2023 Pages: 1186 - 1203

48. High frequency of alternative splicing variants of the oncogene Focal Adhesion Kinase in neuroendocrine tumors of the pancreas and breast

    • Dawei Xie
    • Zheng Wang
    • Guangbiao Zhou

    Research Article 08 September 2023 Pages: 907 - 923

49. Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca²⁺ homeostasis in a murine model of HFpEF

    • Miyesaier Abudureyimu
    • Mingjie Yang
    • Jun Ren

    Research Article 01 September 2023 Pages: 1219 - 1235

50. Minimal residual disease in solid tumors: an overview

    • Yarui Ma
    • Jingbo Gan
    • Yuchen Jiao

    Review 14 September 2023 Pages: 649 - 674