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Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

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Abstract

Exosome therapy holds great promise as a novel approach to improve acute skin wound healing. This review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and beyond. Exosomes, small extracellular vesicles secreted by various stem cells, have emerged as potent mediators of intercellular communication and tissue repair. One advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy, such as immune rejection or stem cells differentiating into unwanted cell types. However, further research is necessary to optimize exosome therapy, not only in the areas of exosome isolation, characterization, and engineering, but also in determining the optimal dose, timing, administration, and frequency of exosome therapy. Thus, optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer, ischemia, or inflammation. This review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 82060245 and 82260254); Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under Contract Nos. R21 AI152832 and R03 AI165170 (PI: Yuanyuan Zhang).

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Author notes

  1. Tianjing Sun and Mo Li contributed equally to the writing of this article.

Authors and Affiliations

  1. Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China

    Tianjing Sun, Mo Li & Anyong Yu

  2. Department of Nephrology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563003, China

    Qi Liu

  3. Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, 64108, USA

    Kun Cheng

  4. Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA

    Jianxing Ma

  5. Wake Forest Institute of Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 27109, USA

    Sean Murphy, Patrick Michael McNutt & Yuanyuan Zhang

Authors
  1. Tianjing Sun
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  2. Mo Li
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  3. Qi Liu
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  4. Anyong Yu
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  6. Jianxing Ma
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  7. Sean Murphy
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  8. Patrick Michael McNutt
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  9. Yuanyuan Zhang
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Corresponding authors

Correspondence to Qi Liu, Anyong Yu or Yuanyuan Zhang.

Ethics declarations

Conflicts of interest Tianjing Sun, Mo Li, Qi Liu, Anyong Yu, Kun Chen, Jianxing Ma, Sean Murphy, Patrick Michael McNutt, and Yuanyuan Zhang declare that they have no conflict of interest.

This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Sun, T., Li, M., Liu, Q. et al. Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair. Front. Med. (2024). https://doi.org/10.1007/s11684-023-1031-9

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