Volume 44, Issue 4

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August 2022

Special Issue: White matter lesions/cognitive decline

Issue Editors:

Farzaneh Sorond,
Anna Csiszar,
Zoltan Ungvari

27 articles in this issue

Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease
Zsolt Bagi
Christopher D. Kroenke
Stephen A. Back
Original Article 25 May 2022 Pages: 1 - 14
Part of 1 collection:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men
Mark Bitsch Vestergaard
Ulrich Lindberg
Henrik Bo Wiberg Larsson
Original Article Open access 01 June 2022 Pages: 1905 - 1923
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Senolytic treatment rescues blunted muscle hypertrophy in old mice
Cory M. Dungan
Vandre C. Figueiredo
Charlotte A. Peterson
Original Article Open access 24 March 2022 Pages: 1925 - 1940
Part of 2 collections:

Animal Models for Translational and Preclinical Geroscience Research

Understanding and overcoming the mechanisms driving age-related sarcopenia
Senescent macrophages in the human adipose tissue as a source of inflammaging
Giulia Matacchione
Jessica Perugini
Fabiola Olivieri
Original Article Open access 05 March 2022 Pages: 1941 - 1960
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
Charlotte Graham
Rhoda Stefanatos
Alberto Sanz
Original Article Open access 30 March 2022 Pages: 1961 - 1974
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells
Siva S. V. P. Sakamuri
Venkata N. Sure
Prasad V. G. Katakam
Original Article 04 April 2022 Pages: 1975 - 1994
Part of 2 collections:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair

Cell Biology of Vascular Aging
Evidence that conserved essential genes are enriched for pro-longevity factors
Naci Oz
Elena M. Vayndorf
Alaattin Kaya
Original Article Open access 13 June 2022 Pages: 1995 - 2006
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies
Setor K. Kunutsor
Nzechukwu M. Isiozor
Jari A. Laukkanen
Original Article Open access 10 January 2022 Pages: 2007 - 2024
Cardiac troponin T and autoimmunity in skeletal muscle aging
Tan Zhang
Xin Feng
Stephen Kritchevsky
Original Article 15 January 2022 Pages: 2025 - 2045
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cells
Parvind Singh
Marianna Szaraz-Szeles
Zsuzsanna Hevessy
Original Article Open access 17 January 2022 Pages: 2047 - 2060
Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication
Cheng-Ya Huang
Liang-Chi Chen
Ing-Shiou Hwang
Original Article 17 January 2022 Pages: 2061 - 2075
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain
Nagendran Muthusamy
Taufika I. Williams
H. Troy Ghashghaei
Original Article 24 January 2022 Pages: 2077 - 2094
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries
Jorge Quarleri
M. Victoria Delpino
Verónica Galvan
Rapid Communication 20 June 2022 Pages: 2095 - 2103
Immune phenotype of the CD4⁺ T cells in the aged lymphoid organs and lacrimal glands
Claudia M. Trujillo-Vargas
Kelsey E. Mauk
Cintia S. de Paiva
Original Article 12 March 2022 Pages: 2105 - 2128
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age
Jessica Cegielski
Matthew S. Brook
Philip J. Atherton
Original Article Open access 18 March 2022 Pages: 2129 - 2138
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow
Chunying Yang
Yidan Pang
Junjie Gao
Original Article 11 May 2022 Pages: 2139 - 2155
Aging-associated changes in motor function are ovarian somatic tissue-dependent, but germ cell and estradiol independent in post-reproductive female mice exposed to young ovarian tissue
Tracy L. Habermehl
Kaden B. Underwood
Jeffrey B. Mason
Original Article 29 March 2022 Pages: 2157 - 2169
Part of 1 collection:

Reproductive Aging
Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain
Gavin Yong-Quan Ng
Dominic Paul Lee Kok Sheng
Thiruma V. Arumugam
Original Article 31 March 2022 Pages: 2171 - 2194
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions
A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response
Tyler A. U. Hilsabeck
Ru Liu-Bryan
Pankaj Kapahi
Original Article 06 April 2022 Pages: 2195 - 2211
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function
Qu Tian
Brendan A. Mitchell
Luigi Ferrucci
Original Article Open access 07 April 2022 Pages: 2213 - 2221
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice
Sara López-Bellón
Sandra Rodríguez-López
José M. Villalba
Original Article Open access 09 May 2022 Pages: 2223 - 2241
Part of 2 collections:

Animal Models for Translational and Preclinical Geroscience Research

Understanding and overcoming the mechanisms driving age-related sarcopenia
Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice
Jonathan A. Zegarra-Valdivia
Jansen Fernandes
Ignacio Torres Aleman
Original Article 23 May 2022 Pages: 2243 - 2257
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study
Jiao Luo
Saskia le Cessie
Diana van Heemst
Original Article Open access 11 June 2022 Pages: 2259 - 2270
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation
Giovanna Casili
Elisa Randi
Csaba Szabo
Original Article Open access 10 June 2022 Pages: 2271 - 2289
Cognitive control, interference inhibition, and ordering of information during working memory in younger and older healthy adults
Mina Mirjalili
Reza Zomorrodi
on behalf of the PACt-MD Study Group
Original Article 12 May 2022 Pages: 2291 - 2303
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory
Yoshinori Takei
Yoko Amagase
Akira Hirasawa
Original Article 20 May 2022 Pages: 2305 - 2318
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment
Jiehui Jiang
Can Sheng
for the Alzheimer’s Disease Neuroimaging Initiative
Original Article 18 May 2022 Pages: 2319 - 2336
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases

Volume 44, Issue 4

Association of cerebral microvascular dysfunction and white matter injury in Alzheimer’s disease

Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties men

Senolytic treatment rescues blunted muscle hypertrophy in old mice

Senescent macrophages in the human adipose tissue as a source of inflammaging

Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies

Glycolytic and Oxidative Phosphorylation Defects Precede the Development of Senescence in Primary Human Brain Microvascular Endothelial Cells

Evidence that conserved essential genes are enriched for pro-longevity factors

Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies

Cardiac troponin T and autoimmunity in skeletal muscle aging

Age-dependent frequency of unconventional T cells in a healthy adult Caucasian population: a combinational study of invariant natural killer T cells, γδ T cells, and mucosa-associated invariant T cells

Effects of task prioritization on a postural-motor task in early-stage Parkinson’s disease: EEG connectivity and clinical implication

Phosphorylation-dependent proteome of Marcks in ependyma during aging and behavioral homeostasis in the mouse forebrain

Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries

Immune phenotype of the CD4⁺ T cells in the aged lymphoid organs and lacrimal glands

The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age

Single-cell transcriptomics identifies premature aging features of TERC-deficient mouse brain and bone marrow

Aging-associated changes in motor function are ovarian somatic tissue-dependent, but germ cell and estradiol independent in post-reproductive female mice exposed to young ovarian tissue

Integrative epigenomic and transcriptomic analyses reveal metabolic switching by intermittent fasting in brain

A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response

Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function

CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice

Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice

Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study

Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation

Cognitive control, interference inhibition, and ordering of information during working memory in younger and older healthy adults

Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory

Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment

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