1. High-velocity resistance training mitigates physiological and functional impairments in middle-aged and older adults with and without mobility-limitation

   • Gustavo Z. Schaun
   • Marcas M. Bamman
   • Cristine L. Alberton

   Original Article 27 January 2022 Pages: 1175 - 1197

   

2. A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved

   • Alexandra Moreira-Pais
   • Rita Ferreira
   • José A. Duarte

   Original Article 04 January 2022 Pages: 1199 - 1213

   

3. Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men

   • Yuxiao Guo
   • Jessica Piasecki
   • Mathew Piasecki

   Original Article Open access 03 December 2021 Pages: 1215 - 1228

   

4. Humoral immune response after COVID-19 infection or BNT162b2 vaccine among older adults: evolution over time and protective thresholds

   • Maxence Meyer
   • Florentin Constancias
   • Patrick Karcher

   Original Article 08 April 2022 Pages: 1229 - 1240

   

5. Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients

   • Ayush Batra
   • Jeffrey R. Clark
   • Eric M. Liotta

   Original Article 11 May 2022 Pages: 1241 - 1254

6. Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors

   • Calin I. Prodan
   • Ayush Batra
   • Eric M. Liotta

   Original Paper 25 April 2022 Pages: 1255 - 1262

   

7. Favipiravir for the treatment of COVID-19 in elderly patients—what do we know after 2 years of COVID-19?

   • Henrietta Papp
   • Zsófia Lanszki
   • Ferenc Jakab

   Short Communication Open access 11 May 2022 Pages: 1263 - 1268

8. Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs

   • Sára Sándor
   • Dávid Jónás
   • Eniko Kubinyi

   Original Article Open access 14 March 2022 Pages: 1269 - 1293

   

9. Untapped research opportunities in China: promising future avenues and potential concerns for aging companion animals

   • Jessica M. Hoffman
   • Shanshan Song
   • Teresa G. Valencak

   Original Article Open access 24 August 2021 Pages: 1295 - 1299

   

10. Novel immortalization approach defers senescence of cultured canine adipose-derived mesenchymal stromal cells

    • Ana Stojiljković
    • Véronique Gaschen
    • Jasmin Bluteau

    Original Article 22 November 2021 Pages: 1301 - 1323

    

11. Impact of medium-chain triglycerides on gait performance and brain metabolic network in healthy older adults: a double-blind, randomized controlled study

    • Tatsushi Mutoh
    • Keiko Kunitoki
    • Yasuyuki Taki

    Original Article 05 April 2022 Pages: 1325 - 1338

    

12. Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions

    • Axel Montagne
    • Samuel R. Barnes
    • Berislav V. Zlokovic

    Opinion Paper 25 April 2022 Pages: 1339 - 1351

    

13. The pathophysiology of chronic subdural hematoma revisited: emphasis on aging processes as key factor

    • Ralf Weigel
    • Lothar Schilling
    • Joachim K. Krauss

    Review 23 April 2022 Pages: 1353 - 1371

    

14. Role of inflammatory markers in the diagnosis of vascular contributions to cognitive impairment and dementia: a systematic review and meta-analysis

    • Carlo Custodero
    • Alessandro Ciavarella
    • Vincenzo Solfrizzi

    Review Open access 29 April 2022 Pages: 1373 - 1392

    

15. Obesity as a premature aging phenotype — implications for sarcopenic obesity

    • Emily Nunan
    • Carson L. Wright
    • Joshua T. Butcher

    Review Open access 26 April 2022 Pages: 1393 - 1405

    

16. Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice

    • Rodney M. Ritzel
    • Yun Li
    • Junfang Wu

    Original Article Open access 22 April 2022 Pages: 1407 - 1440

    

17. Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults

    • Emanuel M. Boutzoukas
    • Andrew O’Shea
    • Adam J. Woods

    Original Article 12 March 2022 Pages: 1441 - 1455

    

18. Long-term exercise pre-training attenuates Alzheimer’s disease–related pathology in a transgenic rat model of Alzheimer’s disease

    • Luodan Yang
    • Chongyun Wu
    • Quanguang Zhang

    Original Article 28 February 2022 Pages: 1457 - 1477

    

19. Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life

    • Hao Ma
    • Tao Zhou
    • Lu Qi

    Original Article 20 March 2022 Pages: 1479 - 1488

    

20. Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults

    • Wan-Hsuan Lu
    • Kelly Virecoulon Giudici
    • for the MAPT/DSA Group

    Original Article 20 April 2022 Pages: 1489 - 1503

    

21. Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity

    • Zhizhen Wang
    • Peng Zheng
    • Xu-Feng Huang

    Original Article Open access 20 April 2022 Pages: 1505 - 1524

    

22. A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease

    • Fabio Macciardi
    • Maria Giulia Bacalini
    • Mark Mapstone

    Original Article Open access 19 May 2022 Pages: 1525 - 1550

    

23. Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease

    • Chao-Wen Lin
    • Tzu-Ting Lai
    • Chin-Hsien Lin

    Original Article 28 April 2022 Pages: 1551 - 1562

    

24. Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease

    • Ye Zhang
    • Yasuko Tatewaki
    • Yasuyuki Taki

    Original Article 08 May 2022 Pages: 1563 - 1574

    

25. Investigating the contribution of white matter hyperintensities and cortical thickness to empathy in neurodegenerative and cerebrovascular diseases

    • Miracle Ozzoude
    • Brenda Varriano
    • Maria Carmela Tartaglia

    Original Article 16 March 2022 Pages: 1575 - 1598

    

26. Analysis of complexity in the EEG activity of Parkinson’s disease patients by means of approximate entropy

    • Chiara Pappalettera
    • Francesca Miraglia
    • Fabrizio Vecchio

    Original Article 28 March 2022 Pages: 1599 - 1607

    

27. HIV, pathology and epigenetic age acceleration in different human tissues

    • Steve Horvath
    • David T. S. Lin
    • Andrew J. Levine

    Original Article Open access 11 April 2022 Pages: 1609 - 1620

    

28. Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

    • Jeremy A. Whitson
    • Richard Johnson
    • Peter S. Rabinovitch

    Original Article 13 April 2022 Pages: 1621 - 1639

    

29. Prediction of disability-free survival in healthy older people

    • Johannes Tobias Neumann
    • Le T. P. Thao
    • on behalf of the ASPREE investigators

    Original Article Open access 14 April 2022 Pages: 1641 - 1655

    

30. SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice

    • Rogerio N. Soares
    • Francisco I. Ramirez-Perez
    • Camila Manrique-Acevedo

    Original Article Open access 15 April 2022 Pages: 1657 - 1675

    

31. Lipidomic signatures from physically frail and robust older adults at hospital admission

    • Robinson Ramírez-Vélez
    • Nicolás Martínez-Velilla
    • Mikel Izquierdo

    Original Article Open access 04 February 2022 Pages: 1677 - 1688

    

32. Interaction of aging with lipoxygenase deficiency initiates hypersplenism, cardiac dysfunction, and profound leukocyte directed non-resolving inflammation

    • Vasundhara Kain
    • Yusuf Mat
    • Ganesh V. Halade

    Original Article 21 December 2021 Pages: 1689 - 1702

    

33. Classical risk factors for primary coronary artery disease from an aging perspective through Mendelian Randomization

    • Swetta A. Jansen
    • Bas Huiskens
    • Raymond Noordam

    Original Article 21 December 2021 Pages: 1703 - 1713

    

34. Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range

    • Ingo Kilimann
    • Diana Wucherer
    • Stefan Johannes Teipel

    Original Article Open access 23 December 2021 Pages: 1715 - 1726

    

35. Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis

    • Mohanraj Rajesh
    • Partha Mukhopadhyay
    • Pal Pacher

    Original Article 22 April 2022 Pages: 1727 - 1741

    

36. Correction to: Cannabinoid receptor 2 activation alleviates diabetes-induced cardiac dysfunction, inflammation, oxidative stress, and fibrosis

    • Mohanraj Rajesh
    • Partha Mukhopadhyay
    • Pal Pacher

    Correction 20 May 2022 Pages: 1743 - 1745

    

37. Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary

    • Jéssica D. Hense
    • Driele N. Garcia
    • Augusto Schneider

    Original Article 23 April 2022 Pages: 1747 - 1759

    

38. Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation

    • Maria E. C. Bruno
    • Sujata Mukherjee
    • Marlene E. Starr

    Original Article Open access 28 April 2022 Pages: 1761 - 1778

    

39. Once-daily feeding is associated with better health in companion dogs: results from the Dog Aging Project

    • Emily E. Bray
    • Zihan Zheng
    • Kathleen F. Kerr

    Original Article 28 April 2022 Pages: 1779 - 1790

    

40. Diabetic patients treated with metformin during early stages of Alzheimer’s disease show a better integral performance: data from ADNI study

    • Carlos Pomilio
    • Nicolás González Pérez
    • Flavia Saravia

    Original Article 20 April 2022 Pages: 1791 - 1805

    

41. Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume

    • Lidija Milicic
    • Michael Vacher
    • Australian Imaging Biomarkers and Lifestyle (AIBL) Study

    Original Article Open access 21 April 2022 Pages: 1807 - 1823

42. Epigenetic clock and methylation studies in marsupials: opossums, Tasmanian devils, kangaroos, and wallabies

    • Steve Horvath
    • Amin Haghani
    • Karen E. Sears

    Original Article Open access 21 April 2022 Pages: 1825 - 1845

    

43. Vitamin D supplementation is associated with slower epigenetic aging

    • Valentin Max Vetter
    • Yasmine Sommerer
    • Ilja Demuth

    Original Article Open access 13 May 2022 Pages: 1847 - 1859

    

44. Telomere length and epigenetic clocks as markers of cellular aging: a comparative study

    • Emily E. Pearce
    • Rotana Alsaggaf
    • Shahinaz M. Gadalla

    Original Article 18 May 2022 Pages: 1861 - 1869

    

45. Elevated skin senescence in young mice causes delayed wound healing

    • Rex Jeya Rajkumar Samdavid Thanapaul
    • Maria Shvedova
    • Daniel S. Roh

    Short Communication 11 April 2022 Pages: 1871 - 1878

    

46. From 1901 to 2022, how far are we from truly understanding the pathogenesis of age-related dementia?

    • Xing Fang
    • Jin Zhang
    • Fan Fan

    Commentary 19 May 2022 Pages: 1879 - 1883

47. Correction to: Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration

    • Jae-Byoung Chae
    • Hyoik Jang
    • Hyewon Chung

    Correction 16 March 2022 Pages: 1885 - 1885

    

48. Correction to: Early dysfunction of functional connectivity in healthy elderly with subjective memory complaints

    • Ricardo Bajo
    • Nazareth P. Castellanos
    • Fernando Maestu

    Correction 23 March 2022 Pages: 1887 - 1887

49. Correction to: Pterocarpus marsupium extract extends replicative lifespan in budding yeast

    • Mitchell B. Lee
    • Michael G. Kiflezghi
    • Matt Kaeberlein

    Correction 23 March 2022 Pages: 1889 - 1889