Volume 43, Issue 3

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June 2021

Special Issue: Metabolic Pathways and Therapeutics to Promote Resilience, Rehabilitation and Delayed Aging

Issue Editors:

Donald K. Ingram,
William Smith,
Paul Pasquina,
Rafael Cabo

31 articles in this issue

Metabolic pathways and therapeutics to promote resilience, rehabilitation and delayed aging
William K. Smith
Donald K. Ingram
Paul Pasquina
Editorial 28 April 2021 Pages: 1069 - 1070
From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience
Brianna J. Stubbs
Andrew P. Koutnik
John C. Newman
Review Open access 02 October 2020 Pages: 1071 - 1081
Intermittent fasting: from calories to time restriction
Eleonora Duregon
Laura C.D. D. Pomatto-Watson
Rafael de Cabo
Review 09 March 2021 Pages: 1083 - 1092
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions
A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin
Jamie N. Justice
Sriram Gubbi
Nir Barzilai
Original Article 09 September 2020 Pages: 1093 - 1112
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
Mitochondrial-derived peptides in aging and age-related diseases
Su-Jeong Kim
Brendan Miller
Kelvin Yen
Original Article 10 September 2020 Pages: 1113 - 1121
Diabetes medications as potential calorie restriction mimetics—a focus on the alpha-glucosidase inhibitor acarbose
Daniel L. Smith Jr
Rachael M. Orlandella
Lyse A. Norian
Original Article 02 October 2020 Pages: 1123 - 1133
Effect of rapamycin on aging and age-related diseases—past and future
Ramasamy Selvarani
Sabira Mohammed
Arlan Richardson
Original Article Open access 10 October 2020 Pages: 1135 - 1158
Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics
Donald K. Ingram
George S. Roth
Original Article 12 November 2020 Pages: 1159 - 1169
Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation
Megha Jhanji
Chintada Nageswara Rao
Mathew Sajish
Original Article 27 November 2020 Pages: 1171 - 1200
Fasting and fasting-mimicking diets for chemotherapy augmentation
Sebastian Brandhorst
Original Article 07 January 2021 Pages: 1201 - 1216
Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock
Carrie A. Sims
Hanna E. Labiner
Joseph A. Baur
Original Article 18 January 2021 Pages: 1217 - 1228
50 years of the “war on cancer”: lessons for public health and geroscience
Colin Farrelly
Opinion Paper 15 April 2021 Pages: 1229 - 1235
Effect of longevity genetic variants on the molecular aging rate
Anastasia Gurinovich
Zeyuan Song
Paola Sebastiani
Original Article 04 May 2021 Pages: 1237 - 1251
Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women
Allen Herbst
Steven J. Prior
Jonathan Wanagat
Original Article 19 March 2021 Pages: 1253 - 1264
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline
Carlos J. Padilla
Markus E. Harrigan
W. David Arnold
Original Article 24 April 2021 Pages: 1265 - 1281
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study
Maria Giulia Bacalini
Anna Reale
Michele Zampieri
Original Article Open access 19 April 2021 Pages: 1283 - 1302
Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)
Brett M. Frye
Payton M. Valure
Carol A. Shively
Original Article 21 February 2021 Pages: 1303 - 1315
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts
David Gomez-Cabrero
Stefan Walter
on behalf of the FRAILOMIC initiative
Original Article 18 February 2021 Pages: 1317 - 1329
T lymphocyte depletion ameliorates age-related metabolic impairments in mice
Daniel W. Trott
Md Torikul Islam
Lisa A. Lesniewski
Original Article 24 April 2021 Pages: 1331 - 1347
Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney
Sathnur Pushpakumar
Sourav Kundu
Utpal Sen
Original Article 12 January 2021 Pages: 1349 - 1367
T cell–depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution
Laura P. Hale
Lynn Cheatham
Gregory D. Sempowski
Original Article 09 January 2021 Pages: 1369 - 1382
Is impaired dopaminergic function associated with mobility capacity in older adults?
Simon Moskowitz
David W. Russ
Brian C. Clark
Original Article 24 November 2020 Pages: 1383 - 1404
Decreased parenchymal arteriolar tone uncouples vessel-to-neuronal communication in a mouse model of vascular cognitive impairment
Ki Jung Kim
Juan Ramiro Diaz
Jessica A. Filosa
Original Article Open access 07 January 2021 Pages: 1405 - 1422
ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging
S. Joshi
K. Chittimalli
Y. P. Jarajapu
Original Article 27 November 2020 Pages: 1423 - 1436
Access to females and early life castration individually extend maximal but not median lifespan in male mice
Michael Garratt
Heather Try
Robert C. Brooks
Original Article 09 January 2021 Pages: 1437 - 1446
Part of 1 collection:

Reproductive Aging
Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats
Alexander P. Young
Jiequan Zhu
Melanie E.M. Kelly
Original Article 05 January 2021 Pages: 1447 - 1463
Cerebral hemodynamics in obesity: relationship with sex, age, and adipokines in a cohort-based study
Oscar Ayo-Martin
Jorge García-García
Tomás Segura
Original Article 15 January 2021 Pages: 1465 - 1479
SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome—the Myhre syndrome
Renuka Kandhaya-Pillai
Deyin Hou
Junko Oshima
Original Article 05 January 2021 Pages: 1481 - 1496
Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
Jonathan D. Dorigatti
Kevin M. Thyne
Adam B. Salmon
Original Article 23 April 2021 Pages: 1497 - 1511
Part of 2 collections:

Animal Models for Translational and Preclinical Geroscience Research

Understanding and overcoming the mechanisms driving age-related sarcopenia
High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice
André Victor Cordeiro
Guilherme Francisco Peruca
Eduardo Rochete Ropelle
Short Communication 31 July 2020 Pages: 1513 - 1518
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study
Yiqiang Zhan
Sara Hägg
Short Communication Open access 08 October 2020 Pages: 1519 - 1525

Volume 43, Issue 3

Metabolic pathways and therapeutics to promote resilience, rehabilitation and delayed aging

From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience

Intermittent fasting: from calories to time restriction

A geroscience perspective on immune resilience and infectious diseases: a potential case for metformin

Mitochondrial-derived peptides in aging and age-related diseases

Diabetes medications as potential calorie restriction mimetics—a focus on the alpha-glucosidase inhibitor acarbose

Effect of rapamycin on aging and age-related diseases—past and future

Glycolytic inhibition: an effective strategy for developing calorie restriction mimetics

Towards resolving the enigma of the dichotomy of resveratrol: cis- and trans-resveratrol have opposite effects on TyrRS-regulated PARP1 activation

Fasting and fasting-mimicking diets for chemotherapy augmentation

Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock

50 years of the “war on cancer”: lessons for public health and geroscience

Effect of longevity genetic variants on the molecular aging rate

Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women

Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline

Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study

Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)

A robust machine learning framework to identify signatures for frailty: a nested case-control study in four aging European cohorts

T lymphocyte depletion ameliorates age-related metabolic impairments in mice

Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidney

T cell–depleted cultured pediatric thymus tissue as a model for some aspects of human age-related thymus involution

Is impaired dopaminergic function associated with mobility capacity in older adults?

Decreased parenchymal arteriolar tone uncouples vessel-to-neuronal communication in a mouse model of vascular cognitive impairment

ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging

Access to females and early life castration individually extend maximal but not median lifespan in male mice

Endothelin B receptor dysfunction mediates elevated myogenic tone in cerebral arteries from aged male Fischer 344 rats

Cerebral hemodynamics in obesity: relationship with sex, age, and adipokines in a cohort-based study

SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome—the Myhre syndrome

Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice

High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice

Association between genetically predicted telomere length and facial skin aging in the UK Biobank: a Mendelian randomization study

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