Volume 43, Issue 1

February 2021

Special Issue: Understanding Senescence in Brain Aging and Alzheimer’s Disease, Special Issue: (Understanding the impact of aging on the susceptibility and response to COVID-19 infection and Special Issue: Understanding and overcoming the mechanisms driving age-related sarcopenia

Issue Editors:

Darren Baker,
ANNA CSISZAR,
JULIE ANDERSEN,
Janet Lord,
Elizabeth Sapey,
Kylie Belchamber,
Paul Greenhaff,
Janet M. Lord,
Niharika Duggal

33 articles in this issue

Plasma dilution improves cognition and attenuates neuroinflammation in old mice
Melod Mehdipour
Taha Mehdipour
Irina M. Conboy
Original Article Open access 15 November 2020 Pages: 1 - 18
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19
Miklós Fagyas
Attila Kertész
Sándor Sipka
Original Article Open access 20 January 2021 Pages: 19 - 29
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
The impact of immuno-aging on SARS-CoV-2 vaccine development
Jennifer Connors
Matthew R. Bell
Elias K. Haddad
Original Article 11 February 2021 Pages: 31 - 51
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
Comparison of clinical characteristics of patients with pandemic SARS-CoV-2-related and community-acquired pneumonias in Hungary – a pilot historical case-control study
Viktor J. Horváth
Noémi Hajdú
Ádám G. Tabák
Original Article Open access 11 November 2020 Pages: 53 - 64
Part of 1 collection:

Understanding the impact of aging on the susceptibility and response to COVID-19 infection
Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading
Marcus M. Lawrence
Douglas W. Van Pelt
Esther E. Dupont-Versteegden
ORIGINAL ARTICLE 25 June 2020 Pages: 65 - 83
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing
Andrew Wilhelmsen
Kostas Tsintzas
Simon W. Jones
Original Article Open access 02 February 2021 Pages: 85 - 110
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?
Derek M. Huffman
Anna Csiszar
Zoltan Ungvari
Editorial 28 January 2021 Pages: 111 - 113
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging
Angela O. Dorigatti
Stacy A. Hussong
Veronica Galvan
Methods Paper 15 October 2020 Pages: 115 - 124
Traumatic brain injury-induced cerebral microbleeds in the elderly
Luca Toth
Andras Czigler
Peter Toth
Review Open access 03 October 2020 Pages: 125 - 136
Effects of sleep deprivation on endothelial function in adult humans: a systematic review
Brady J. Holmer
Stephanie S. Lapierre
Demetra D. Christou
Review 09 February 2021 Pages: 137 - 158
Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment
Dianna H. Nguyen
J. Thomas Cunningham
Nathalie Sumien
Review 09 September 2020 Pages: 159 - 166
Part of 1 collection:

Reproductive Aging
Aging, stress, and senescence in plants: what can biological diversity teach us?
Marina Pérez-Llorca
Sergi Munné-Bosch
Review 15 February 2021 Pages: 167 - 180
Cell-to-cell variation in gene expression and the aging process
Alexander R. Mendenhall
George M. Martin
Rozalyn M. Anderson
Review 17 February 2021 Pages: 181 - 196
Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling
Adam Institoris
Ciaran Murphy-Royal
Grant R. Gordon
Original Article 22 October 2020 Pages: 197 - 212
Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease
Melisa Gumus
Namita Multani
for the Alzheimer’s Disease Neuroimaging Initiative
Original Article 09 January 2021 Pages: 213 - 223
Are the 50’s, the transition decade, in choroid plexus aging?
Ana Tahira
Fernanda Marques
Joana Almeida Palha
Original Article Open access 12 February 2021 Pages: 225 - 237
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Association of physical activity and sedentary time with structural brain networks—The Maastricht Study
Laura W. M. Vergoossen
J. F. A. Jansen
M. T. Schram
Original Article Open access 09 October 2020 Pages: 239 - 252
Part of 1 collection:

White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair
Internalize at your peril: internalizing disorders as risk factors for dementia—cohort study
Yoram Barak
David Barson
Diana Paleacu
Original Article 16 October 2020 Pages: 253 - 261
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
Katrin Rauen
Claudia B. Späni
Nikolaus Plesnila
Original Article Open access 17 October 2020 Pages: 263 - 278
“Cerebral small vessel disease and other influential factors of cognitive impairment in the middle-aged: a long-term observational cohort PURE-MIND study in Poland”
Dorota Szcześniak
Joanna Rymaszewska
Andrzej Szuba
Original Article Open access 19 October 2020 Pages: 279 - 295
A short digital eye-tracking assessment predicts cognitive status among adults
Joshua L. Gills
Nick T. Bott
Michelle Gray
Original Article 01 September 2020 Pages: 297 - 308
HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status
Alaa N. Qrareya
Fakhri Mahdi
Jason J. Paris
Original Article 17 September 2020 Pages: 309 - 327
Senescent cell accumulation mechanisms inferred from parabiosis
Omer Karin
Uri Alon
Original Article Open access 25 November 2020 Pages: 329 - 341
Biomarkers of senescence in non-human primate adipose depots relate to aging
Kylie Kavanagh
Chrissy Sherrill
Amanda Olivier
Original Article 23 July 2020 Pages: 343 - 352
A chemical biology approach to identifying molecular pathways associated with aging
Antonio Currais
Ling Huang
David Schubert
Original Article 23 July 2020 Pages: 353 - 365
Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging
Juliet Akkaoui
Chiaki Yamada
Alexandru Movila
Original Article 26 August 2020 Pages: 367 - 376
The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging
Vienna E. Brunt
Thomas J. LaRocca
Douglas R. Seals
Original Article 29 August 2020 Pages: 377 - 394
Quest for a summary measure of biological age: the health and retirement study
Eileen M. Crimmins
Bharat Thyagarajan
Jessica Faul
Original Article Open access 05 February 2021 Pages: 395 - 408
Morbidity compression or expansion? A temporal analysis of the age at onset of non-communicable diseases in India
Sanjay K. Mohanty
Justin Rodgers
S. V. Subramanian
Original Article 07 January 2021 Pages: 409 - 422
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening
Rachel A. Gioscia-Ryan
Zachary S. Clayton
Douglas R. Seals
Original Article 11 June 2020 Pages: 423 - 432
Alterations in the estrogen receptor profile of cardiovascular tissues during aging
Rakesh Gurrala
Isabella M. Kilanowski-Doroh
Sarah H. Lindsey
Original Article 09 February 2021 Pages: 433 - 442
Part of 2 collections:

Cell Biology of Vascular Aging

Reproductive Aging
Sex differences in the contribution of different physiological systems to physical function in older adults
Siana Jones
Martin G. Schultz
Alun D. Hughes
Original Article Open access 11 February 2021 Pages: 443 - 455
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
Correction to: Hydrogen sulfide ameliorates aging-associated changes in the kidney
Hak Joo Lee
Denis Feliers
Balakuntalam S. Kasinath
Correction 28 January 2021 Pages: 457 - 457

Volume 43, Issue 1

Plasma dilution improves cognition and attenuates neuroinflammation in old mice

Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19

The impact of immuno-aging on SARS-CoV-2 vaccine development

Comparison of clinical characteristics of patients with pandemic SARS-CoV-2-related and community-acquired pneumonias in Hungary – a pilot historical case-control study

Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading

Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing

Heterochronic blood exchange attenuates age-related neuroinflammation and confers cognitive benefits: do microvascular protective effects play a role?

Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging

Traumatic brain injury-induced cerebral microbleeds in the elderly

Effects of sleep deprivation on endothelial function in adult humans: a systematic review

Estrogen receptor involvement in vascular cognitive impairment and vascular dementia pathogenesis and treatment

Aging, stress, and senescence in plants: what can biological diversity teach us?

Cell-to-cell variation in gene expression and the aging process

Whole brain irradiation in mice causes long-term impairment in astrocytic calcium signaling but preserves astrocyte-astrocyte coupling

Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease

Are the 50’s, the transition decade, in choroid plexus aging?

Association of physical activity and sedentary time with structural brain networks—The Maastricht Study

Internalize at your peril: internalizing disorders as risk factors for dementia—cohort study

Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span

“Cerebral small vessel disease and other influential factors of cognitive impairment in the middle-aged: a long-term observational cohort PURE-MIND study in Poland”

A short digital eye-tracking assessment predicts cognitive status among adults

HIV-1 Tat promotes age-related cognitive, anxiety-like, and antinociceptive impairments in female mice that are moderated by aging and endocrine status

Senescent cell accumulation mechanisms inferred from parabiosis

Biomarkers of senescence in non-human primate adipose depots relate to aging

A chemical biology approach to identifying molecular pathways associated with aging

Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

Quest for a summary measure of biological age: the health and retirement study

Morbidity compression or expansion? A temporal analysis of the age at onset of non-communicable diseases in India

Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening

Alterations in the estrogen receptor profile of cardiovascular tissues during aging

Sex differences in the contribution of different physiological systems to physical function in older adults

Correction to: Hydrogen sulfide ameliorates aging-associated changes in the kidney

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