Estimating drug potency in the competitive target mediated drug disposition (TMDD) system when the endogenous ligand is included. Begum AlaybeyogluHo Wa (Jacky) ChengAndrew M. Stein Original Paper 08 February 2021 Pages: 447 - 464
A population K-PD model analysis of long-term testosterone inhibition in prostate cancer patients undergoing intermittent androgen deprivation therapy Joost DeJonghMaurice AhsmanNelleke Snelder Original Paper 04 February 2021 Pages: 465 - 477
Population pharmacokinetic characteristics of cemiplimab in patients with advanced malignancies Feng YangAnne J. PaccalyA. Thomas DiCioccio Original Paper Open access 16 March 2021 Pages: 479 - 494
Constant infusion case of one compartment pharmacokinetic model with simultaneous first-order and Michaelis–Menten elimination: analytical solution and drug exposure formula Xiaotian WuMin ChenJun Li Original Paper 24 February 2021 Pages: 495 - 508
Reduction of quantitative systems pharmacology models using artificial neural networks Abdallah DerbalahHesham S. Al-SallamiStephen B. Duffull Original Paper 02 March 2021 Pages: 509 - 523
A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases Jacob LeanderMikael SunnåkerJoanna Parkinson Original Paper Open access 17 March 2021 Pages: 525 - 541
Optimum multi-drug regime for compartment model of tumour: cell-cycle-specific dynamics in the presence of resistance Bharti PanjwaniVijander SinghVijay Mohan Original Paper 22 March 2021 Pages: 543 - 562
Use of population PK/PD approach to model the thrombin generation assay: assessment in haemophilia A plasma samples spiked by a TFPI antibody Raphaël CrépinClaire MorinPierre Chelle Original Paper 12 April 2021 Pages: 563 - 580
Comparing the performance of first-order conditional estimation (FOCE) and different expectation–maximization (EM) methods in NONMEM: real data experience with complex nonlinear parent-metabolite pharmacokinetic model Thanh BachGuohua An Original Paper 21 April 2021 Pages: 581 - 595
Fast screening of covariates in population models empowered by machine learning Emeric SibieudeAkash KhandelwalNadia Terranova OriginalPaper Open access 21 May 2021 Pages: 597 - 609
Correction to: Modeling the acute effects of exercise on glucose dynamics in healthy nondiabetic subjects Spencer FrankAbdulrahman JbailyAndrew J. Szeri Correction 01 June 2021 Pages: 611 - 612
Correction to: Abstracts for the Ninth American Conference on Pharmacometrics (ACoP9) Correction 11 June 2021 Pages: 613 - 614