1. Editorial

   OriginalPaper Pages: 1 - 2

2. The β-lactam antibiotics: past, present, and future

   • Arnold L. Demain
   • Richard P. Elander

   OriginalPaper Pages: 5 - 19

3. Penicillin and cephalosporin biosynthesis: Mechanism of carbon catabolite regulation of penicillin production

   • Juan F. Martín
   • Javier Casqueiro
   • AFF1>Santiago Gutiérrez

   OriginalPaper Pages: 21 - 31

4. Recent advances in the structure and function of isopenicillin N synthase

   • Rachel Kreisberg-Zakarin
   • Ilya Borovok
   • Gerald Cohen

   OriginalPaper Pages: 33 - 39

5. Compartmentalization and transport in β-lactam antibiotic biosynthesis by filamentous fungi

   • Mart van de Kamp
   • Arnold J.M. Driessen
   • Wil N. Konings

   OriginalPaper Pages: 41 - 78

6. Gene organization and plasticity of the β-lactam genes in different filamentous fungi

   • Santiago Gutiérrez
   • Francisco Fierro
   • Juan F. Martín

   OriginalPaper Pages: 81 - 94

7. Transcriptional control of expression of fungal ß-lactam biosynthesis genes

   • Olivier Litzka
   • Katharina Then Bergh
   • Axel A. Brakhage

   OriginalPaper Pages: 95 - 105

8. Biosynthesis and molecular genetics of cephamycins

   • Paloma Liras

   OriginalPaper Pages: 109 - 124

9. Biosynthesis and Molecular Genetics of Clavulanic Acid

   • Susan E. Jensen
   • Ashish S. Paradkar

   OriginalPaper Pages: 125 - 133

10. Molecular genetics of carbapenem antibiotic biosynthesis

    • Simon J. McGowan
    • Matthew T. G. Holden
    • George P. C. Salmond

    OriginalPaper Pages: 135 - 141

11. Metabolic control analysis of the penicillin biosynthetic pathway: the influence of the lld-ACV:bisACV ratio on the flux control

    • Hanne Aae Theilgaard
    • Jens Nielsen

    OriginalPaper Pages: 145 - 154

12. Announcement

    OriginalPaper Pages: 163 - 163