Abstract
The aim and objective of the present investigation was to evaluate the antiarthritic and antioxidant effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside (UFD) in chemically induced arthritic rats. The different doses of the UFD were tested against the turpentine oil (TO), formaldehyde induced acute arthritis and complete fruend’s adjuvant (CFA) induced chronic arthritis in Wistar rats. Arthritic assessment and body weight was measured at regular interval till 28 days. On day 28, all the groups animals were anaesthetized, blood were collected from the puncturing the ratro orbital and estimated the hematological parameters. The animals were sacrificed; synovial tissue was extracted and estimated the malonaldehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD). The different doses of the UFD showed the protective effect against turpentine oil, formaldehyde induced acute arthritis and CFA induced chronic arthritis at dose dependent manner. Acute model of arthritis such as TOand formaldehyde induced inflammation due to releasing of the inflammatory mediators; significantly inhibited by the UFD at dose dependent manner. CFA induced arthritic rats treated with the different doses of the UFD showed the inhibitory effect on the delayed increase in joint diameter as seen in arthritic control group rats. UFD significantly improved the arthritic index, body weight and confirmed the antiarthritic effect. UFD showed the effect on the hematological parameter such as improved the level of the RBC, Hb and decline the level of the EBC, ESR and confirmed the immune suppressive effect. UFD significantly improved the level of the endogenous antioxidant and confirmed the antioxidant effect. This present investigation suggests that the UFD has prominent antiarthritic impact which can be endorsed to its antiarthritic and antioxidant effects.
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Abotsi WMK, Woode E, Ainooson GK, Amo-Barimah AKA, Boakye-Gyasi E (2010) Antiarthritic and antioxidant activity of Ficus exasperata P. Beauv. (Moraceae). Pharmacognosy Res 2(2):89–97
Arnett FC, Edworthy SM, Block DA, McShane DJ, Fries JF, Cooper NS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324
Austin JH, Drabkin DL (1935) Spectrophotometric studies: III. Methemoglobin. J Biol Chem 112:67–88
Bai X, Liang W, Cheng J, Ma L, Liu Y, Shi G, Wang Y, Gu J (2012) Inhibitory effect and antifungal mechanism of umbelliferone on plant pathogenic fungi. Adv Intell Soft Comput 134:693–702
Biemond P, Swaak AJ, Koster JF (1984) Protective factors against oxygen free radicals and hydrogen peroxide in rheumatoid arthritis synovial fluid. Arthritis Rheum 27:760–765
Campo MG, Avenoso A, Campo S, Feriazzo AM, Altavilla D, Calatroni A (2003) Efficacy of treatment with glycosaminoglycans on experimental commagen-induced arthritis in rats. Arthritis Res Ther 5:R122–R131
Chesbrough M, Mc Arthur J (1972) Laboratory Manual of Rural Tropical Hospitals. The English Language Book Society and Churchill Livingstone. 145
David G, Sykes AJ (1951) Westergren and Wintrobe methods of estimating ESR compared. Br Med J 2(4746):1496–1497
Di Rosa M, Giroud JP, Willoughby DA (1971) Studies on the 5. Mediators of the acute inflammatory response induced in rats in different sites by Carrageenan and turpentine. J Pathol 104:15–29
Eric GB, Lawrence JL (1996) Rheumatoid arthritis and its therapy, the textbook of therapeutic drugs and disease management, 6th edn. Williams and Wilkins Company, Baltimore, pp 579–595
Gao Q, Shan J, Di L, Jiang L, Xu H (2008) Therapeutic effects of daphnetin on adjuvant-induced arthritic rats. J Ethnopharmacol 120:259–263
Ghosh MN (1984) Fundamentals of experimental pharmacology. Scientific Book Agency, Calcutta, 153
Gomes A, Bhattacharya S, Chakraborty M, Bhattacharjee P, Mishra R, Gomes A (2010) Anti-arthritic activity of Indian monocellate cobra (Naja kaouthia) venom on adjuvant induced arthritis. Toxicon 55:670–673
Hadjigogos K (2003) The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med 45:7–13
Hanson JM, Morley J, Soria-Herrera C (1974) Anti-inflammatory 6. Property of 401 (MCD-peptide), a peptide from the venom of bee Apis mellifera (L.). Br J Pharmacol 50:383–392
Islam MN, Choi RJ, Jin SE, Kim YS, Ahn BR, Zhao D, Jung HA, Choi JS (2012) Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva. J Ethnopharmacol 144(1):175–181
Jalalpure SS, Mandavkar YD, Khalure PR, Shinde GS, Shelar PA, Shah AS (2011) Antiarthritic activity of various extracts of Mesua ferrea Linn. Seed. J Ethnopharmacol 138:700–704
Kaithwas G, Majumdar DK (2010) Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats. Inflammopharmacology 18(3):127–136
Kaithwas G, Gautam R, Jachak SM, Saklani A (2012) Antiarthritic effects of Ajuga bracteosa Wall ex Benth. In acute and chronic models of arthritis in albino rats. Asian pacific of tropical biomedicine. 185–188
Kaur P, Kumar M, Singh B, Kumar S, Kaur S (2012) Amelioration of oxidative stress induced by oxidative mutagens and COX-2 inhibitory activity of umbelliferone isolated from Glycyrrhiza glabra L. Asian Pac J Trop Biomed S120-S126
Kim KW, Shin YS, Kim KS, Chang YC, Park KK, Park JB, Choe JY, Lee KG, Kang MS, Park YG, Kim CH (2008) Suppressive effects of bee venom on the immune responses in collagen-induced arthritis in rats. Phytomedicine 15:1099–1107
Koleva II, Niederlander HAG, Van Beek TA (2000) An online HPLC method for detection of radical scavenging compounds in complex mixtures. Anal Chem 72:2323–2328
Kumar V, Ahmed D, Anwar F, Ali M, Mujeeb M (2013a) Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-alpha-D-glucopyranosyl-(2I->1II)-alpha-D-glucopyranoside in streptozotocin induced diabetic rats. Springerplus 2:639
Kumar V, Ahmed D, Verma A, Anwar F, Ali M, Mujeeb M (2013b) Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. An ethno medicinal plant with antidiabetic, antihyperlipidemic and anti oxidative activity. BMC Complement Altern Med 13:273
Kumar V, Verma A, Ahmed D, Sachan NK, Anwar F, Mujeeb M (2013c) Fostered antiarthritic upshot of moringa oleifera lam. stem bark extract in diversely induced arthritis in wistar rats with plausible mechanism. IJPSR, 4(10):3894–3901
Kumar V, Anwar F, Ahmed D, Verma A, Ahmed A, Damanhouri ZA, Mishra V, Ramteke PW, Bhatt PC, Mujeeb M (2014). Paederia foetida Linn. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity. BMC Complementary and Alternative Medicine 14:76
Lunec J, Halloran SP, White AG, Dormandy TL (1981) Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol 8:233–245
Mishra NK, Bstia S, Mishra G, Chowdary KA, Patra S (2011) Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in Freund ’s adjuvant induced arthritic rats. J Pharmacol Educ Res 2(2):92–98
Muthu R, Thangavel P, Selvaraj N, Ramalingam R, Vaiyapuri M (2013) Synergistic and individual effects of umbelliferone with 5-flurouracil on the status of lipid peroxidation and antioxidant defense against 1, 2-dimethylhydrazine induced rat colon carcinogenesis. Biomed Prev Nutr 3(1):74–82
Nair V, Singh S, Gupta YK (2011) Evaluation of disease modifying activity of Colchicum luteum Baker in experimental arthritis. J Ethanopharmacol 133:303–307
Nair VD, Panneerselvam R, Gopi R (2012) Studies on methanolic extract of Rauvolfia species from Southern Western Ghats of India – in vitro antioxidant properties, characterization of nutrients and phytochemicals. Ind Crop Prod 39:17–25
Nakagawa Y, Tayama S (1995) Cytotoxicity of propyl gallate and related compounds in rat hepatocytes. Arch Toxicol 69(3):204–208
Nam JH, Jung HJ, Choi J, Lee KT, Park HJ (2006) The anti-gastropathic and anti-rheumatic effect of Niga-ichigoside F1 and 23-hydroxytormenthic acid isolated from the unripe fruits of Rubus coreanus in a rat model. Biol Pharm Bull 29:967–970
Nawar WW (1996) Lipids. In: Fennema OR (ed) Food chemistry. Marcel Dekker, New York
Owoyele BV, Adenekan OT, Soladoye AO (2011) Effect of honey on inflammation and nitric oxide production in Wistar rats. Zhong Xi Yi Jie Xue Bao 9(4):447–452
Parthiban P, Kanagavalli K, Sathiyarajeswaran P, Anbu J, Krishnaprakash G (2013) Antiarthritic activity of Kanthaga Parpam (KP) (Official Siddha Drug) in Complete Freund’s Adjuvant (CFA) induced arthritic rats. Int J Pharmacol Res Rev 2(5):1–7
Patil KS, Suryavanshi J (2007) Effect of Celastrus paniculatus Willd. Seed on adjuvant induced arthritis in rats. Pharmacogn Mag 3:177–181
Patil KR, Patil CR, Jadhav RB, Mahajan VK, Patil PR, Gaikwad PS (2011) Anti-Arthritic Activity of Bartogenic Acid Isolated from Fruits of Barringtonia racemosa Roxb. (Lecythidaceae). Evidence-Based Complementary and Alternative Medicine Volume 785245:7
Paval J, Kaitheri KS, Potu BK, Govindan S, Kumar RS, Narayanan SN, Moorkoth S (2009) Anti-arthriticpotential of the plant Justicia gendarussa Burm F. Clinics 64(4):357–360
Pearson CM, Wood FD (1959) Studies of polyarthritis and other 21. Lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathological characteristics and some modifying factors. Arthritis Rheum 2:440–459
Purnima A, Rajani GP, Arulmozhi S, Hulkoti B, Desai BG, Rajendran R (2006) Antiinflammatory and Anti-ulcerogenic effect of Crotalaria juncea Linn. In albino rats. Iran J Pharmacol Ther 5(2):141–144
Ramani YR, Pradhan S (2012) Antiarthritic Activity of Acetone Extract of Terminalia Chebula. WebmedCentral Pharmacol 3(2):WMC003057
Ramesh B, Pugalendi KV (2006) Impact of Umbelliferone (7- hydroxyl coumarin) on hepatic marker enzyme in streptozotocin induced diabetic rats. Indian J Pharmacol 38(3):209–210
Rezaee R, Behravan E, Behravan J, Soltani F, Naderi Y, Emami B, Iranshihi M (2014) Antigenotoxic activities of the natural dietary coumarins umbelliferone, herniarin and 7-isopentenyloxy coumarin on human lymphocytes exposed to oxidative stress. Drug Chem Toxicol 37(2):144–148
Salahuddin MD, Jalalpure SS (2010) Antidiabetic activity of aqueous fruit extract of Cucumis trigonus Roxb. In streptozotocin-induced-diabetic rats. J Ethnopharmacol 127:565–567
Singh S, Majumdar DK (1996) Effect of fixed oil of Ocimum sanctum against experimentally induced arthritis and joint edema in laboratory animals. Pharmacol Biol 34(3):218–222
Singh S, Nair V, Gupta YK (2011) Antiarthritic activity of Majoon Suranjan (a polyherbal Unani formulation) in rat. Indian J Med Res 134:384–388
Toyama Dde O, Diz Filho EB, Cavada BS, Da Rocha BA, De Oliveira SC, Cotrim CA, Soares VC, Delatorre P, Marangoni S, Toyama MH (2011) Umbelliferone induces changes in the structure and pharmacological activities of Bn IV, a phospholipase A(2) isoform isolated from Bothrops neuwiedi. Toxicon 57(6):851–860
Turner MA (1965) Screening methods in pharmacology. Academic, New York, p 26
William JK (1996) Arthritis and allied condition, a textbook of rheumatology (Vol. 1), 3rd edn. A Waverly Company, Baltimore, pp 207–226
Winter CA, Risely EA, Nuss GW (1962) Carrageenin-induced edema in the hind paw of the rat as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 111:544–547
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Kumar, V., Anwar, F., Verma, A. et al. Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats. J Food Sci Technol 52, 3402–3411 (2015). https://doi.org/10.1007/s13197-014-1403-x
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DOI: https://doi.org/10.1007/s13197-014-1403-x