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Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review

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The journal of nutrition, health & aging

Abstract

Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.

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  1. Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Periférico Norte Km. 33.5, Tablaje Catastral 13615, Col. Chuburná de Hidalgo Inn, 97203, Mérida, Yucatán, México

    E. E. Martínez Leo & M. R. Segura Campos

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Martínez Leo, E.E., Segura Campos, M.R. Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review. J Nutr Health Aging 23, 694–699 (2019). https://doi.org/10.1007/s12603-019-1240-8

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