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The Role of Oxidative Stress in Neurodegenerative Diseases

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Studies on Psychiatric Disorders

Abstract

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) are worldwide health and economic problems related to increased life expectancy. The exact cause of the etiology of these disorders is not known. Neurodegenerative diseases are of multifactorial etiology, including the role of epigenetic and environmental factors. It has been proposed that oxidative stress–related damage of several macromolecules plays a key role in their pathogenesis. Here, we want to revise the current knowledge regarding the role of reactive oxygen species (ROS) and oxidative stress in neurodegeneration occurring in neurological diseases such as AD, PD, ALS, and MS.

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Abbreviations

8-OHG:

8-hydroxyguanine

AD:

Alzheimer’s disease

ALS:

Amyotrophic lateral sclerosis

ApoE:

Apolipoprotein E

APP:

β-amyloid precursor protein

Aβ:

Amyloid-β

BER:

Base excision repair

CD:

Caudate nucleus

CHMP2B:

Charged multivesicular body protein 2B

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

Cu/Zn SOD:

Copper/zinc superoxide dismutase

DA:

Dopamine

FUS/TLS:

Fused in sarcoma/translated in liposarcoma

GFAP:

Glial fibrillary acidic protein

GS:

Glutamine synthetase

GSH:

Glutathione

HNE:

4-hydroxynonenal

Hsp:

Heat shock protein

l-DOPA:

l-3,4-dihydroxyphenylalanine

LRRK2:

Leucine-rich repeat kinase 2

MCI:

Mild cognitive impairment

mETC:

Mitochondrial electron transport chain

MS:

Multiple sclerosis

mtDNA:

Mitochondrial DNA

nDNA:

Nuclear DNA

NF-L:

Neurofilament-light

NFTs:

Neurofibrillary tangles

NO:

Nitric oxide

Nrf2:

Nuclear erythroid 2-related factor 2

PD:

Parkinson’s disease

PINK-1:

PTEN-induced putative kinase 1

ROS:

Reactive oxygen species

SN:

Substantia nigra

SOD2:

Superoxide dismutase2

TDP-43:

TAR DNA-binding protein

VAPB:

Vesicle-associated membrane protein B

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Authors and Affiliations

  1. Department of Neurology and Stroke, Medical University of Lodz, Zeromskiego 113 Str., Lodz, 90-549, Poland

    Dominika Książek-Winiarek M.Sc. & Andrzej Głąbiński M.D., Ph.D.

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  1. Dominika Książek-Winiarek M.Sc.
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  2. Andrzej Głąbiński M.D., Ph.D.
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Correspondence to Andrzej Głąbiński M.D., Ph.D. .

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Editors and Affiliations

  1. Department of Biological Psychiatry of the Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz, Poland

    Anna Dietrich-Muszalska

  2. Department of Neurochemistry, New York State Institute for Basic Research, Staten Island, New York, USA

    Ved Chauhan

  3. Departments of Psychiatry and Physiology & Biophysics, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Sylvain Grignon

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Książek-Winiarek, D., Głąbiński, A. (2015). The Role of Oxidative Stress in Neurodegenerative Diseases. In: Dietrich-Muszalska, A., Chauhan, V., Grignon, S. (eds) Studies on Psychiatric Disorders. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0440-2_8

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