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Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease

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Abstract

Parkinson’s disease (PD) is a neurological disorder in which oxidative stress and reactive oxygen species productions are proposed to be involved in its pathogenesis. Despite considerable advancement in Selenium’s (Se) molecular biology and metabolism, we do not know much about the cell type-specific pattern of Se distribution in the brain of PD humans and experimental animals. Although, there is plenty of evidence around the role of Se deficiency in PD’s pathogenesis impacting lipid peroxidation and reducing glutathione (GSH) and glutathione peroxidase (GPX). It has been suggested that Se has an inducible role in selenium-dependent GPX activity in PD animals and humans. However, calcium as a second messenger regulates the neuron cells’ essential activities, but its overloading leads to cellular oxidative stress and apoptosis. Therefore, Se’s antioxidant role can affect calcium signaling and alleviate its complications. There are signs of Se and Selenoproteins incorporation in protecting stress oxidative in various pathways. In conclusion, there is convincing proof for the crucial role of Se and Calcium in PD pathogenesis.

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Authors and Affiliations

  1. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Sanaz Salaramoli

  2. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Sanaz Salaramoli & Seyed Isaac Hashemy MD-PhD.

  3. Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran

    Hamidreza Joshaghani

  4. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Isaac Hashemy MD-PhD.

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  1. Sanaz Salaramoli
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Salaramoli, S., Joshaghani, H. & Hashemy, S.I. Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson’s Disease. Ind J Clin Biochem 37, 257–266 (2022). https://doi.org/10.1007/s12291-022-01031-1

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