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Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis

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Abstract

Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case–control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects. Evidence was obtained on eight single-nucleotide polymorphisms (SNPs): IL1A −889 C>T (rs1800587), IL1B +3953/4 C>T (rs1143634), IL4 −589/90 C>T (rs2243250), IL6 −174 G>C (rs1800795), IL10 −592 C>A (rs1800872), IL10−1082 A>G (rs1800896), IL12B −1188 A>C (rs3212227) and IL28B C>T (rs12979860). The IL1B +3953/4 C>T variant appears to increase the risk of HIV acquisition, under the assumption of a recessive genetic model (odds ratio (OR): 4.47, 95% CI: 2.35–8.52). The AA homozygotes of the IL10 -592 C>A SNP had an increased, marginally nonsignificant, risk (OR: 1.39, 95% CI: 0.97–2.01). It reached, however, significance in subanalyses (OR: 1.49, 95% CI: 1.04–2.12). Finally, the well-studied hepatitis C virus (HCV) infection IL28B (rs12979860) CT/TT genotypes were associated with a 27% decrease in HIV infection risk, especially in populations infected with HCV (OR: 0.73, 95% CI: 0.57–0.95). Interleukin signalling is perhaps important in HIV infection and some interleukin genetic variants may affect the risk of HIV acquisition. Approaches targeting specific genes and genomewide association studies should be conducted to decipher the effect of these polymorphisms.

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Authors and Affiliations

  1. Hellenic Centre for Disease Control and Prevention, 15123, Athens, Greece

    Chrissa G. Tsiara & Dimitra Paraskeva

  2. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, 11527, Athens, Greece

    Chrissa G. Tsiara & Angelos Hatzakis

  3. Medical School, University of Cyprus, 2029, Strovolos, Nicosia, Cyprus

    Georgios K. Nikolopoulos & Katerina G. Pantavou

  4. Department of Computer Science and Biomedical Informatics, University of Thessaly, 35100 , Lamia, Greece

    Niki L. Dimou, Pantelis G. Bagos & Georgia G. Braliou

  5. Noguchi Memorial Institute for Medical Research, University of Ghana, P.O.Box LG 581, Accra, Ghana

    Benedicta Mensah

  6. Healthcare Management Postgraduate Program, Open University of Cyprus, 2220, Nicosia, Cyprus

    Michael Talias

  7. Humanitas Clinical and Research Center, 20089, Milan, Italy

    Stefanos Bonovas

  8. Department of Biomedical Sciences, Humanitas University, 20090, Milan, Italy

    Stefanos Bonovas

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  1. Chrissa G. Tsiara
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  2. Georgios K. Nikolopoulos
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Correspondence to Georgios K. Nikolopoulos.

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Tsiara, C.G., Nikolopoulos, G.K., Dimou, N.L. et al. Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis. J Genet 97, 235–251 (2018). https://doi.org/10.1007/s12041-018-0907-y

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  • DOI: https://doi.org/10.1007/s12041-018-0907-y

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