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New players in cytokine control of HIV infection

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Abstract

Cytokines are involved early in the pathogenesis of HIV infection and disease progression as a component of immunologic dysregulation and immunodeficiency and as determinants controlling virus replication. Several steps, before and after retroviral integration into host DNA in T cells and macrophages, are affected by cytokines whereas CCR5 and CXCR4 binding chemokines can interfere with viral entry. A growing number of potential players—including the γ-common interleukin (IL)-7, IL-15, and IL-21 together with IL-17, IL-18, IL-19, IL-20, IL-23, and IL-27—are discussed in terms of their perturbation in HIV infection and of their effects on virus replication. Thus, an increasing intersection of HIV infection and the cytokine network represents a crucial determinant of virus replication and immunologic dysregulation and will likely play a key role in the development of effective strategies of HIV prevention and immunologic reconstitution.

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Authors and Affiliations

  1. P2/P3 Laboratories, DIBIT, Via Olgettina n. 58, 20132, Milano, Italy

    Guido Poli

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  1. Massimo Alfano
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  2. Andrea Crotti
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  3. Elisa Vicenzi
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  4. Guido Poli
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Correspondence to Guido Poli.

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Alfano, M., Crotti, A., Vicenzi, E. et al. New players in cytokine control of HIV infection. Curr HIV/AIDS Rep 5, 27–32 (2008). https://doi.org/10.1007/s11904-008-0005-5

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  • DOI: https://doi.org/10.1007/s11904-008-0005-5

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